Reactome | Me-PalmS-ESR2 [plasma membrane]

Me-PalmS-ESR2 [plasma membrane]

Stable Identifier

R-HSA-9637787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Estrogen receptor beta, ESR2_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92731 ESR2

Gene Names

ESR2, ESTRB, NR3A2

Chain

chain:1-530

Reference Genes

BioGPS Gene:2100 ESR2

COSMIC (genes):ESR2 ESR2

CTD Gene:2100 ESR2

dbSNP Gene:2100 ESR2

ENSEMBL:ENSG00000140009 ESR2

ENSEMBL_homo_sapiens_GENE:ENSG00000140009.19 ESR2

HGNC:3468 ESR2

KEGG Gene (Homo sapiens):2100 ESR2

Monarch:2100 ESR2

NCBI Gene:2100 ESR2

OMIM:601663 ESR2

UCSC:Q92731 ESR2

Reference Transcript

Other Identifiers

11741669_a_at

11741670_x_at

11741983_a_at

11747111_x_at

11750908_a_at

11762037_x_at

11762046_at

1442_at

16793759

2100

210780_3p_at

210780_PM_at

210780_at

211117_PM_x_at

211117_x_at

211118_PM_x_at

211118_x_at

211120_PM_x_at

211120_x_at

240777_PM_at

240777_at

31436_s_at

31437_r_at

34431_at

3568199

3568200

3568201

3568202

3568203

3568204

3568205

3568206

3568207

3568208

3568216

3568218

3568219

3568221

3568222

3568223

3568225

3568226

3568227

3568228

3568229

3568232

3568233

3568234

3568235

3568238

3568239

3568240

3568241

3568244

3568248

3568250

3568251

3568252

46979_at

7979583

A_23_P54100

A_33_P3347911

GE54563

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005496

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005739

GO:0006351

GO:0006355

GO:0006357

GO:0007165

GO:0007267

GO:0008270

GO:0008289

GO:0014070

GO:0019899

GO:0023052

GO:0030284

GO:0030308

GO:0030520

GO:0033993

GO:0034056

GO:0043226

GO:0043231

GO:0043565

GO:0045893

GO:0045944

GO:0046872

GO:0048019

GO:0051091

GO:0060089

GO:0071391

GO:0071392

GO:0098772

GO:0140110

GO:1990837

HMNXSV003049641

Hs.194486.0.A1_3p_at

ILMN_1740045

ILMN_2390457

PH_hs_0025883

PH_hs_0036203

X99101_at

g2911151_3p_at

g2961558_3p_s_at

g3345671_3p_at

g4894662_3p_a_at

Participates

as a candidate of

Me-PalmS-ESRs [plasma membrane] (Homo sapiens)

Other forms of this molecule

PalmS-ESR2 [cytosol]

PalmS-ESR2 [plasma membrane]

ESR2 [nucleoplasm]

ESR2 [cytosol]

Inferred To

esr2a [plasma membrane] (Danio rerio)

kni [plasma membrane] (Drosophila melanogaster)

knrl [plasma membrane] (Drosophila melanogaster)

esr2 [plasma membrane] (Xenopus tropicalis)

Homologues of Me-PalmS-ESR2 [plasma membrane] (Drosophila melanogaster)

Me-PalmS-ESR2 [plasma membrane] (Gallus gallus)

ESR2 [plasma membrane] (Bos taurus)

ESR2 [plasma membrane] (Canis familiaris)

ESR2 [plasma membrane] (Sus scrofa)

Esr2 [plasma membrane] (Mus musculus)

Esr2 [plasma membrane] (Rattus norvegicus)

eg [plasma membrane] (Drosophila melanogaster)

ERR [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

S-palmitoyl-L-cysteine at 399

Coordinate

399

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

omega-N-methyl-L-arginine at unknown position

PsiMod Name

omega-N-methyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.

Cross References

RefSeq

XP_016876573.1, NP_001278641.1, NP_001201831.1, NP_001258806.1, XP_016876572.1, NP_001035365.1, NP_001258805.1, XP_016876568.1, XP_016876570.1, NP_001428.1, XP_016876571.1, XP_016876569.1, NP_001278652.1

ZINC - World Drugs

ESR2_HUMAN

Guide to Pharmacology - Targets

621

OpenTargets

ENSG00000140009

ZINC - FDA approved

ESR2_HUMAN

ZINC - Substances

ESR2_HUMAN

ZINC target

Q92731

ZINC - Biogenic

ESR2_HUMAN

PRO

Q92731

PDB

1ZAF, 2I0G, 3OMP, 7XWQ, 1X7J, 2Z4B, 3OMO, 4J26, 7XWR, 7XVY, 7XWP, 2YJD, 1YY4, 1L2J, 3OLS, 2FSZ, 2QTU, 1NDE, 3OMQ, 3OLL, 4J24, 2JJ3, 2NV7, 1U3R, 4ZI1, 1X76, 1U9E, 1U3Q, 2GIU, 2YLY, 1X7B, 1QKM, 5TOA, 1U3S, 7XVZ, 1YYE, 1X78

ZINC - Investigational

ESR2_HUMAN

ZINC - Metabolites

ESR2_HUMAN

GeneCards

Q92731

HPA

ENSG00000140009-ESR2

Ensembl

ENSG00000140009, ENSP00000335551, ENSP00000343925, ENSP00000451582, ENST00000555278, ENSP00000450488, ENST00000358599, ENSP00000452426, ENSP00000450699, ENST00000341099, ENST00000353772, ENST00000344288, ENST00000267525, ENSP00000345616, ENST00000553796, ENSP00000267525, ENSP00000351412, ENST00000557772, ENST00000554572

Pharos - Targets

Q92731

ZINC - Predictions - Purchasable

ESR2_HUMAN

Orphanet

25062

HMDB Protein

HMDBP00450

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.626	5
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.597	6
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.597	3
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.591	4
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.532	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	5
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.527	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.527	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.527	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	5
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.527	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.527	2
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.508	4
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	8
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.462	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.462	2
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.462	2
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.462	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.462	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.462	2
UniProt:P50416 CPT1A	1	CPT1A [mitochondrial outer membrane] (R-HSA-400161)	0.462	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.462	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.462	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.462	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.462	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.462	2
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.462	2
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.462	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.462	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.462	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.462	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.462	2

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