Reactome | di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

Stable Identifier

R-COV-9696920

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum-Golgi intermediate compartment

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
32366695	Site-specific glycan analysis of the SARS-CoV-2 spike Watanabe, Y, Crispin, M, Allen, JD, McLellan, JS, Wrapp, D	Science	2020

External Reference Information

External Reference

UniProt:P0DTC2 S

Gene Names

S, 2

Chain

signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273

Reference Genes

BioGPS Gene:43740568 S

KEGG Gene (Hepatitis C Virus):43740568 S

Monarch:43740568 S

NCBI Gene:43740568 S

Reference Transcript

RefSeq:NC_045512.2 S

Participates

as a component of

di-antennary N-glycan-PALM-Spike trimer [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)

Other forms of this molecule

fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]

tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

nascent Spike [endoplasmic reticulum lumen]

14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]

Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]

high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]

high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]

fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]

fully glycosylated Spike [virion membrane]

complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]

complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]

complex N-glycan-PALM-Spike S2 Fragment [virion membrane]

complex N-glycan-PALM-Spike S1 Fragment [virion membrane]

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074

Coordinate

1074

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122

Coordinate

122

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603

Coordinate

603

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61

Coordinate

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709

Coordinate

709

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717

Coordinate

717

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801

Coordinate

801

Modification

high-mannose N-glycan-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234

Coordinate

234

Modification

Man(9) N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

palmitoylated-L-cysteine at unknown position

PsiMod Name

palmitoylated-L-cysteine

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 1098

Coordinate

1098

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 1134

Coordinate

1134

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 1158

Coordinate

1158

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 1173

Coordinate

1173

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 1194

Coordinate

1194

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 149

Coordinate

149

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 165

Coordinate

165

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 17

Coordinate

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 282

Coordinate

282

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 331

Coordinate

331

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 343

Coordinate

343

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 616

Coordinate

616

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 657

Coordinate

657

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

N4-(N-acetylamino)glucosyl-L-asparagine (di-antennary complex N-glycan group) at 74

Coordinate

Modification

di-antennary complex N-glycan group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724390.1

GlyGen

P0DTC2

PDB

7FDI, 7DX5, 7E86, 6YLA, 7OAO, 6ZXN, 7KNI, 7CAB, 6VW1, 7V7N, 7L7K, 7D4G, 7KQB, 7L02, 7KML, 7M7B, 6M0J, 7BEM, 7MZG, 7MJN, 7LS9, 7LAB, 7V7J, 7K8X, 7CWN, 7KDK, 6YZ7, 7E23, 7DD8, 7KFV, 7V89, 7N1U, 7CHC, 6XEY, 7R6W, 7LC8, 7JVB, 7NXC, 7V80, 7LXZ, 7V78, 7DDD, 7CZR, 6YM0, 7EB5, 7LCN, 7NDA, 7MKB, 7M7W, 6VXX, 7FDK, 6ZGG, 7E88, 7N8I, 7MZH, 7KL9, 6ZP5, 7L06, 7E39, 7K8Y, 6WPT, 7LYP, 7DK3, 7LWS, 7C8V, 7N1V, 6XF5, 6XE1, 7V7Z, 7JMW, 7M71, 7MJJ, 7KDJ, 7L7F, 7KKK, 7ND8, 7E7Y, 7CZP, 7LRS, 7MZF, 6VSB, 7C8D, 7MJM, 7CHB, 7CZZ, 7LAA, 7D2Z, 7V7I, 7K8W, 6ZP1, 6WPS, 7JV4, 7C53, 7N1T, 7DD2, 7B3O, 7V87, 7B62, 7JVA, 7A98, 7FDH, 7NXB, 7DX4, 7LXY, 7KEC, 7KNH, 7OAN, 7V77, 7LWQ, 7A5S, 7DK0, 7D30, 7N6E, 7KKL, 7ND9, 6ZGE, 7EB4, 7N8H, 7CZQ, 6ZP2, 7BEL, 7LRT, 6ZWV, 7KMK, 7C8J, 7CWM, 7LYO, 7JV6, 7MJK, 6ZFO, 7CN9, 7V88, 7A91, 6YZ5, 7K4N, 7K8M, 6XC2, 7M53, 7NDC, 7DWX, 7KFY, 7JW0, 7K90, 7FG3, 7NT9, 7CZT, 6M1V, 7DX8, 7L2D, 7LWK, 7V7P, 6ZB4, 7KE4, 7EDG, 7N1X, 7CWS, 7S0C, 7DK5, 7BWJ, 6VYB, 7KMZ, 7N9B, 7KLH, 7LDJ, 7E3J, 7KRR, 7OAQ, 7R8L, 7L4Z, 7V7A, 7KLW, 7BNN, 7LY2, 7EAM, 6ZLR, 7MKM, 7V82, 7M8K, 7FG7, 7S0D, 7CAI, 7L2E, 7M6D, 7V7Q, 7LWL, 6ZH9, 7N0H, 7DK6, 7BYR, 7CZU, 7E8C, 6ZOW, 7V8B, 7MZJ, 7CHH, 7BH9, 7A92, 7OAU, 7E3K, 7KN3, 7MDW, 6XKQ, 7DEO, 7L56, 7LWU, 7V7D, 6X2A, 7LQ7, 7BEP, 7ORB, 7JWB, 7LSS, 7V79, 7OAP, 7OR9, 7F63, 7CAC, 7OLZ, 7V7O, 7LYQ, 7R7N, 7LWI, 7FG2, 7LD1, 7DX6, 7JVC, 6XKL, 7E3B, 7CWO, 7BEN, 7EDF, 7KQE, 7DK4, 6M17, 7KDL, 7KFW, 7F62, 6YOR, 7KLG, 6ZP7, 7R6X, 7LJR, 7KMS, 7K43, 7CHE, 7BNM, 7V81, 7LY0, 7L0N, 7NDB, 7MKL, 7CAH, 7C8W, 7M8J, 7KFX, 6ZGI, 7L3N, 7LOP, 7L2C, 7CZS, 7LWJ, 7DX7, 7DDN, 7V8A, 6XKP, 7K8Z, 7M42, 7MZI, 7L09, 7S0B, 7N9A, 7KRQ, 7LWT, 6X29, 7MJL, 7LO4, 7K45, 7BEO, 7LM8, 7E3C, 6XF6, 7CHF, 7N1W, 7N0G, 7ORA, 7JJC, 7RTD, 7LWN, 7A94, 7E5R, 7V84, 7RNJ, 7CHP, 7MZL, 7RKV, 7JZL, 7KJ2, 7MF1, 7KMB, 7K8T, 7V7S, 7KDG, 7NTC, 7M6F, 7L2F, 7LYK, 7ND4, 7E8M, 7V7F, 7MEJ, 7NX6, 7KSG, 7MM0, 7KN5, 7P78, 7N9E, 7M8T, 7DZX, 7LWW, 7D03, 7L57, 6ZBP, 7CWU, 7AKD, 7N1E, 7LQV, 7M6G, 6XC7, 7KZB, 7D0B, 7DX0, 7MMO, 7EJ4, 7KN6, 7JZM, 6X79, 7KJ3, 7EH5, 7N4J, 7CAN, 7M0J, 7EAZ, 7NX7, 7MZM, 7RAL, 6XM3, 7B14, 6ZOY, 7RR0, 7BEH, 7N9T, 6ZCZ, 7CYH, 7CZW, 7NEH, 7KXK, 7DEU, 7K9J, 7DZY, 7EY4, 6LXT, 7KE8, 7EDJ, 7RA8, 6LVN, 7MTD, 7R8O, 7L58, 7LWM, 7NDD, 7KM5, 7DWY, 7JWY, 7DMU, 6Z97, 7P77, 7E3O, 7CHO, 6XC3, 7RKU, 6ZB5, 7DPM, 7MZK, 7MLZ, 7S0E, 7N1A, 7M6E, 7K8S, 7BNO, 7V7R, 7DX9, 7S4S, 7KGJ, 6XLU, 7NTA, 7BZ5, 7N1Y, 7ND3, 7V8C, 7R8M, 7E3L, 6Z2M, 7K9H, 7KRS, 7OAY, 7D00, 7CWT, 7M8S, 7LWV, 7EDH, 7N9C, 7KE6, 6XC4, 7DWZ, 6X2C, 7LY3, 7EAN, 7JX3, 6X6P, 7V83, 7E5O, 7KXJ, 7N4I, 7NKT, 6XM0, 7KGK, 7CAK, 7N1B, 7DK7, 6ZOX, 7EY0, 7CZV, 6Z43, 7E8F, 7NEG, 7DET, 7R8N, 7K9I, 7KN4, 7ME7, 7A93, 7N3I, 6X2B, 7MTC, 7DZW, 7V7E, 7P3D, 7KE7, 7EDI, 6ZHD, 7KS9, 7LXW, 7M6I, 7LWO, 6XDG, 7MJI, 7DX2, 7FDG, 7DF4, 7A96, 7NX9, 7K8V, 7A29, 7AD1, 7A5R, 7CZY, 6XCN, 7V26, 7V7H, 7JZU, 7LYM, 7KMH, 6ZP0, 7MY3, 7BEJ, 7N1Q, 7CYV, 7V86, 7JMO, 7CJF, 7JV2, 7A4N, 6ZDH, 7A97, 7V76, 7V7V, 7E7X, 7LXX, 7KNE, 7DX3, 7LQW, 7D0D, 7LWP, 7KEB, 7C01, 7V2A, 7KDI, 6ZER, 7B18, 7N6D, 7MY8, 7EB3, 7NXA, 7CT5, 7P7B, 7N64, 7CN4, 7KMI, 7DHX, 7DJZ, 7CH5, 7ND7, 7LYN, 7CWL, 7KJ5, 7BEK, 7L7E, 7JMP, 7EZV, 7E7D, 7C2L, 7DCX, 7M6H, 7E5Y, 7V7T, 7MJG, 7CHS, 6XRA, 7A95, 7K9K, 7DX1, 7KN7, 7K8U, 7NX8, 7JJI, 6XM4, 7LYL, 7V7G, 6ZOZ, 6ZDG, 6W41, 7BEI, 6XCM, 7ND5, 7KMG, 7JZN, 6XR8, 7P79, 7DF3, 6LZG, 7RTR, 7MFU, 7M3I, 7KE9, 7CDI, 7EY5, 7M8U, 7CM4, 7D0C, 7EB0, 7V7U, 7RXD, 7N1F, 7EYA, 7RW2, 7MJH, 7EK6, 7KEA, 6XM5, 7A25, 7B17, 7KDH, 7CH4, 7JJJ, 7MZN, 7K9Z, 7KNB, 6XS6, 7CZX, 7MTE, 7R95, 7MY2, 7DCC, 7L5B, 7L7D, 7EJ5, 7KJ4, 7ND6, 7V85, 7E7B, 7CYP, 7N62, 7P7A, 7LX5, 7CDJ

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.997	224
UniProt:P0DTC2 S	16	fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638)	0.985	54
UniProt:Q9NNX6 CD209	1	CD209 [plasma membrane] (R-HSA-2079928)	0.888	12
UniProt:Q9H2X3 CLC4M			0.857	12
UniProt:P09958 FURIN	4	FURIN [Golgi lumen] (R-HSA-448351) FURIN [plasma membrane] (R-HSA-2159856) FURIN [extracellular region] (R-HSA-1181103) FURIN [Golgi membrane] (R-HSA-157049)	0.854	5
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.746	8
UniProt:Q9C0B5 ZDHHC5	1	ZDHHC5 [Golgi membrane] (R-HSA-9766353)	0.725	5
UniProt:Q7Z5G4 GOLGA7	3	GOLGA7 [extracellular region] (R-HSA-6800449) GOLGA7 [tertiary granule lumen] (R-HSA-6800164) GOLGA7 [Golgi membrane] (R-HSA-9647777)	0.725	5
UniProt:Q8R0I0	1	Ace2 [plasma membrane] (R-MMU-2022344)	0.688	4
UniProt:Q8IUN9-2 CLEC10A			0.683	4
UniProt:P35247-PRO_0000017465 SFTPD			0.683	11
UniProt:Q96D42 HAVR1			0.667	7
UniProt:Q96L92 SNX27			0.664	16
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.655	9
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.652	7
IntAct:EBI-26657218 PEPTIDE			0.645	7
ChEBI:17033 BILIVERDIN			0.642	9
UniProt:Q58DD0 ACE2			0.641	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.639	9
maltose [ChEBI:17306]	2	Mal [cytosol] (R-ALL-868706) Mal [extracellular region] (R-ALL-188986)	0.623	3
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.623	4
ChEBI:28304 HEPARIN			0.623	5
UniProt:Q96LC7 SIGLEC10	1	SIGLEC10 [plasma membrane] (R-HSA-197707)	0.623	2
UniProt:P07711 CTSL	8	CTSL(114-288) [extracellular region] (R-HSA-449861) CTSL(292-333) [extracellular region] (R-HSA-449863) CTSL1(114-288) [lysosomal lumen] (R-HSA-1181225) CTSL1(114-288) [early endosome lumen] (R-HSA-4127474) CTSL(292-333) [endolysosome lumen] (R-HSA-1679026) CTSL(114-288) [endolysosome lumen] (R-HSA-1679050) CTSL(114-288) [endocytic vesicle lumen] (R-HSA-9686686) CTSL(292-333) [endocytic vesicle lumen] (R-HSA-9686680)	0.623	3
UniProt:P59665-PRO_0000006773 DEFA1			0.618	3
UniProt:A5CKE2 A5CKE2			0.618	3
UniProt:P31431 SDC4	20	SDC4 [plasma membrane] (R-HSA-2090061) SDC4 [lysosomal lumen] (R-HSA-2090041) HS(6)-SDC4 [lysosomal lumen] (R-HSA-2090058) HS(6)-SDC4 [Golgi lumen] (R-HSA-2076330) HS(5)-SDC4 [Golgi lumen] (R-HSA-2076510) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674)	0.599	17
hemin [ChEBI:50385]	1	hemin [cytosol] (R-ALL-421489)	0.59	2
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.59	2
IntAct:EBI-27090397 RC-101			0.558	2
cholesterol [ChEBI:16113]	20	CHOL [lipid droplet] (R-ALL-163586) CHOL [lysosomal membrane] (R-ALL-8876478) cholesterol [endosome lumen] (R-ALL-171083) cholesterol [endosome membrane] (R-ALL-171135) cholesterol [clathrin-coated endocytic vesicle membrane] (R-ALL-171069) CHOL [smooth endoplasmic reticulum] (R-ALL-8866305) CHOL [lysosomal lumen] (R-ALL-8848047) CHOL [early endosome] (R-ALL-2429660) CHOL [mitochondrial matrix] (R-ALL-193840) CHOL [transport vesicle membrane] (R-ALL-216762) CHOL [endoplasmic reticulum lumen] (R-ALL-174672) CHOL [cornified envelope] (R-ALL-8847704) cholesterol [mitochondrial intermembrane space] (R-ALL-196084) CHOL [mitochondrial outer membrane] (R-ALL-8951853) CHOL [mitochondrial inner membrane] (R-ALL-193156) CHOL [cytosol] (R-ALL-176478) cholesterol [endocytic vesicle lumen] (R-ALL-2239405) CHOL [plasma membrane] (R-ALL-171095) CHOL [endoplasmic reticulum membrane] (R-ALL-193384) CHOL [extracellular region] (R-ALL-171149)	0.558	5
N-acetylneuraminic acid [ChEBI:17012]	4	Neu5Ac [Golgi lumen] (R-ALL-975925) Neu5Ac [lysosomal lumen] (R-ALL-428639) Neu5Ac [nucleoplasm] (R-ALL-4085414) Neu5Ac [cytosol] (R-ALL-428633)	0.558	2
UniProt:Q07021-PRO_0000018590 C1QBP			0.558	2
UniProt:Q61830 Mrc1	4	Mrc1 [plasma membrane] (R-MMU-1236776) Mrc1 [plasma membrane] (R-MMU-1216515) Mrc1 [clathrin-coated endocytic vesicle membrane] (R-MMU-1236818) Mrc1 [early endosome membrane] (R-MMU-1236785)	0.558	2
lipopolysaccharide [ChEBI:16412]	5	LPS [endocytic vesicle lumen] (R-ALL-2239413) LPS [cell wall] (R-ALL-6803081) LPS [endosome lumen] (R-ALL-2201311) LPS [plasma membrane] (R-ALL-433850) LPS [extracellular region] (R-ALL-166005)	0.558	3
UniProt:P35247 SFTPD	3	SFTPD [endoplasmic reticulum membrane] (R-HSA-5685278) SFTPD [clathrin-coated endocytic vesicle] (R-HSA-5686343) SFTPD [extracellular region] (R-HSA-391099)	0.544	3
UniProt:P01130 LDLR	4	LDLR [endolysosome membrane] (R-HSA-6784818) LDLR [endosome membrane] (R-HSA-171127) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [plasma membrane] (R-HSA-171053)	0.537	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.537	4
IntAct:EBI-26657222 PEPTIDE			0.525	2
IntAct:EBI-26657225 PEPTIDE			0.525	2
IntAct:EBI-26997889 ACE2			0.524	2
UniProt:A0A1S3APE5 A0A1S3APE5			0.524	2
UniProt:Q5EGZ1	1	Ace2 [plasma membrane] (R-RNO-2022344)	0.524	2
UniProt:E2DHI3 E2DHI3			0.524	2
UniProt:Q14416 GRM2	1	GRM2 [plasma membrane] (R-HSA-420468)	0.524	4
linoleic acid [ChEBI:17351]	6	LINA [endoplasmic reticulum lumen] (R-ALL-2046044) LINA [cytosol] (R-ALL-1132021) LINA [extracellular region] (R-ALL-879520) LINA [early endosome] (R-ALL-879655) LINA [lipid droplet] (R-ALL-2864095) LINA [nucleoplasm] (R-ALL-400158)	0.522	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.518	7
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972) COPB2 [Golgi membrane] (R-HSA-6808739)	0.499	3
UniProt:Q5EA32	1	TRPV2 [plasma membrane] (R-BTA-2671909)	0.499	3
UniProt:Q9Y5S1 TRPV2	1	TRPV2 [plasma membrane] (R-HSA-2671909)	0.499	2
UniProt:Q5MNZ6 WDR45B	1	WDR45B [cytosol] (R-HSA-5678303)	0.499	4
UniProt:Q15436 SEC23A	4	p-S742,T747 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.499	20
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.499	2
UniProt:P26038 MSN	4	p-T558-MSN [cytosol] (R-HSA-9663005) MSN(2-448)-p-7Y ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN [cytosol] (R-HSA-437350)	0.499	20
UniProt:P0DTD1-PRO_0000449625 REP			0.488	2
UniProt:P0DTD1-PRO_0000449627 REP			0.488	2
UniProt:P0DTD1-PRO_0000449628 REP			0.488	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.483	10

Cite Us!