Reactome | MAPK9 [cytosol]

MAPK9 [cytosol]

Stable Identifier

R-HSA-450355

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

JNK2

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - NPM1-ALK-dependent MAPK8,9 phosphorylation (Homo sapiens)
        
        MAPK8,9 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
        
        MAPK8,9,10 [cytosol] (Homo sapiens)
        
        MAPK9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P45984 MAPK9

Gene Names

MAPK9, JNK2, PRKM9, SAPK1A

Chain

chain:1-424

Reference Genes

BioGPS Gene:5601 MAPK9

COSMIC (genes):MAPK9 MAPK9

CTD Gene:5601 MAPK9

dbSNP Gene:5601 MAPK9

ENSEMBL:ENSG00000050748 MAPK9

ENSEMBL_homo_sapiens_GENE:ENSG00000050748.18 MAPK9

HGNC:6886 MAPK9

KEGG Gene (Homo sapiens):5601 MAPK9

Monarch:5601 MAPK9

NCBI Gene:5601 MAPK9

OMIM:602896 MAPK9

UCSC:P45984 MAPK9

Reference Transcript

Other Identifiers

11720237_s_at

11720238_at

11720239_a_at

11740489_at

1238_at

17003898

203218_PM_at

203218_at

210570_PM_x_at

210570_x_at

225781_PM_at

225781_at

2890602

2890604

2890606

2890607

2890608

2890609

2890610

2890611

2890612

2890613

2890614

2890618

2890619

2890622

2890624

2890627

2890628

2890629

2890632

2890635

2890639

2890640

2890641

2890643

2890647

2890648

2890652

2890655

38431_at

45319_at

52185_at

5601

8116402

A_23_P167692

A_33_P3400192

GE58908

GE81189

GO:0000165

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006468

GO:0006954

GO:0007254

GO:0010628

GO:0010744

GO:0012501

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0031398

GO:0032436

GO:0033554

GO:0034614

GO:0036211

GO:0038095

GO:0042752

GO:0043226

GO:0046686

GO:0048511

GO:0050804

GO:0061833

GO:0065003

GO:0071276

GO:0071803

GO:0090398

GO:0090594

GO:0097190

GO:0098685

GO:0106310

GO:0140096

GO:1900017

GO:2001235

HMNXSV003022713

HMNXSV003057289

Hs.246857.2.A1_3p_at

ILMN_2400292

ILMN_2400297

PH_hs_0023911

TC05002145.hg

U09759_at

g1463132_3p_a_at

Participates

as a member of

Other forms of this molecule

p-T183,Y185-MAPK9 [cytosol]

p-T183,Y185-MAPK9 [nucleoplasm]

Inferred To

Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)

Homologues of MAPK9 [cytosol] (Dictyostelium discoideum)

MAPK9 [cytosol] (Bos taurus)

MAPK9 [cytosol] (Caenorhabditis elegans)

MAPK9 [cytosol] (Canis familiaris)

MAPK9 [cytosol] (Dictyostelium discoideum)

MAPK9 [cytosol] (Drosophila melanogaster)

MAPK9 [cytosol] (Gallus gallus)

MAPK9 [cytosol] (Mus musculus)

MAPK9 [cytosol] (Rattus norvegicus)

MAPK9 [cytosol] (Saccharomyces cerevisiae)

MAPK9 [cytosol] (Schizosaccharomyces pombe)

MAPK9 [cytosol] (Sus scrofa)

kgb-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_620709.1, XP_006714954.1, NP_002743.3, NP_620708.1, NP_001128516.1, NP_001295173.1, XP_016865130.1, XP_016865127.1, NP_620707.1

ZINC - World Drugs

MK09_HUMAN

Guide to Pharmacology - Targets

1497

OpenTargets

ENSG00000050748

ZINC - FDA approved

MK09_HUMAN

ZINC - Substances

MK09_HUMAN

ZINC - Biogenic

MK09_HUMAN

ZINC target

P45984

PRO

P45984

PDB

7CML, 3E7O, 7N8T, 8ELC, 3NPC

ZINC - Investigational

MK09_HUMAN

IntEnz

2.7.11.24

GeneCards

P45984

HPA

ENSG00000050748-MAPK9

Ensembl

ENSP00000345524, ENST00000425491, ENSP00000377028, ENSP00000397422, ENSG00000050748, ENSP00000394560, ENST00000452135, ENST00000455781, ENST00000393360, ENST00000343111, ENSP00000389338

Pharos - Targets

P45984

ZINC - Predictions - Purchasable

MK09_HUMAN

HMDB Protein

HMDBP01304

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.841	9
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.841	9
UniProt:Q9BY84 DUSP16	3	DUSP16 [cytosol] (R-HSA-5675336) DUSP16 [nucleoplasm] (R-HSA-5675337) Ac-55-DUSP16 [cytosol] (R-HSA-9636576)	0.8	8
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.781	9
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.773	5
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P45985 MAP2K4	4	MAP2K4 [cytosol] (R-HSA-168107) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4(1-?) [cytosol] (R-HSA-5211402) MAP2K4(?-399) [cytosol] (R-HSA-5211396)	0.547	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	3