Reactome | p-Y348-SYK [cytosol]

p-Y348-SYK [cytosol]

Stable Identifier

R-HSA-437953

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-SYK(Y348), Tyrosine-protein kinase SYK , Spleen tyrosine kinase

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43405 SYK

Gene Names

SYK

Chain

chain:1-635

Reference Genes

BioGPS Gene:6850 SYK

COSMIC (genes):SYK SYK

CTD Gene:6850 SYK

dbSNP Gene:6850 SYK

ENSEMBL:ENSG00000165025 SYK

HGNC:11491 SYK

KEGG Gene (Homo sapiens):6850 SYK

Monarch:6850 SYK

NCBI Gene:6850 SYK

OMIM:600085 SYK

UCSC:P43405 SYK

Reference Transcript

Other Identifiers

0003990546

11719718_a_at

11754925_a_at

1630_s_at

17086708

207540_PM_s_at

207540_s_at

209269_PM_s_at

209269_s_at

226068_PM_at

226068_at

3178954

3178955

3178958

3178959

3178960

3178961

3178964

3178965

3178969

3178971

3178972

3178973

3178977

3178980

3178982

3178984

3178986

3178989

3178994

3178995

3178996

3178997

3178998

36885_at

548_s_at

55564_at

6850

7896689

7896705

8156321

A_14_P110676

A_14_P117239

A_23_P9255

GE57710

GO:0000166

GO:0001525

GO:0001775

GO:0001784

GO:0001819

GO:0001820

GO:0001945

GO:0002092

GO:0002223

GO:0002250

GO:0002281

GO:0002283

GO:0002366

GO:0002376

GO:0002554

GO:0002696

GO:0002862

GO:0003674

GO:0004672

GO:0004674

GO:0004712

GO:0004713

GO:0004715

GO:0005102

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006606

GO:0006810

GO:0006913

GO:0006950

GO:0007155

GO:0007159

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007229

GO:0007267

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009887

GO:0010543

GO:0010803

GO:0015031

GO:0016020

GO:0016170

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018108

GO:0019370

GO:0019815

GO:0019899

GO:0019901

GO:0019902

GO:0022607

GO:0030154

GO:0030168

GO:0030593

GO:0031234

GO:0031334

GO:0031410

GO:0031623

GO:0032009

GO:0032481

GO:0032725

GO:0032733

GO:0032735

GO:0032752

GO:0032753

GO:0032755

GO:0032757

GO:0032760

GO:0032928

GO:0032930

GO:0032991

GO:0033630

GO:0034641

GO:0035325

GO:0035556

GO:0038063

GO:0038095

GO:0038096

GO:0038156

GO:0040011

GO:0042101

GO:0042169

GO:0042592

GO:0042742

GO:0043167

GO:0043226

GO:0043274

GO:0043280

GO:0043306

GO:0043313

GO:0043366

GO:0043410

GO:0043507

GO:0044281

GO:0045087

GO:0045579

GO:0045588

GO:0045780

GO:0046638

GO:0046641

GO:0046777

GO:0048514

GO:0048646

GO:0048856

GO:0048870

GO:0050731

GO:0050764

GO:0050778

GO:0050850

GO:0050853

GO:0051090

GO:0051712

GO:0065003

GO:0070372

GO:0071226

GO:0071396

GO:0071404

GO:0071639

GO:0090237

GO:0090330

GO:0097110

GO:0120162

GO:1990858

HMNXSV003042953

Hs.74101.1.S2_3p_a_at

Hs.74101.2.S1_3p_a_at

Hs.74101.2.S1_3p_at

ILMN_1681350

ILMN_2059549

PH_hs_0022924

S80267_s_at

TC09000428.hg

g4507328_3p_a_at

Participates

as a member of

p-Y348-SYK/LCK [cytosol] (Homo sapiens)

as an input of

p-Y348-SYK binds VAV family (Homo sapiens)

as a component of

as an output of

p-Y348-SYK dissociates (Homo sapiens)

Other forms of this molecule

p-Y-SYK [cytosol]

p-Y-SYK [plasma membrane]

SYK [plasma membrane]

p-6Y-SYK [cytosol]

SYK [cytosol]

Inferred To

phospho-syk [cytosol] (Danio rerio)

phospho-syk [cytosol] (Xenopus tropicalis)

phospho-Syk [cytosol] (Mus musculus)

phospho-Syk [cytosol] (Rattus norvegicus)

phospho-SYK [cytosol] (Bos taurus)

phospho-SYK [cytosol] (Canis familiaris)

phospho-SYK [cytosol] (Gallus gallus)

phospho-SYK [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 348

Coordinate

348

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003168.2, NP_001128524.1, NP_001167639.1, NP_001167638.1, XP_011517248.1, XP_005252204.1

ZINC - World Drugs

KSYK_HUMAN

Guide to Pharmacology - Targets

2230

OpenTargets

ENSG00000165025

ZINC - FDA approved

KSYK_HUMAN

ZINC - Substances

KSYK_HUMAN

ZINC target

P43405

ZINC - Biogenic

KSYK_HUMAN

PRO

P43405

PDB

4XG2, 4PV0, 4FL2, 4FL3, 1XBC, 4XG4, 6ZCR, 5CXZ, 1XBA, 4PUZ, 3TUB, 4XG7, 6ZCQ, 4YJP, 4I0S, 4RX9, 4FL1, 1CSZ, 3SRV, 1A81, 6ZCY, 5TR6, 5GHV, 3TUD, 4WNM, 3BUW, 5CXH, 6ZC0, 7SA7, 4FZ7, 4YJR, 4PX6, 4YJS, 3FQH, 6SSB, 6ZCX, 4RSS, 3VF8, 4XG8, 5CY3, 1CSY, 4GFG, 1XBB, 4XG3, 3FQS, 4DFL, 4YJQ, 4XG6, 4DFN, 6ZCP, 4FZ6, 4YJV, 5T68, 5C26, 6HM6, 5LMA, 6VOV, 4RX8, 4I0T, 4FYN, 5LMB, 6HM7, 5C27, 4FYO, 4XG9, 4YJT, 5TIU, 4YJO, 4RX7, 4I0R, 4F4P, 4YJU, 5TT7, 5Y5U, 6ZCU, 3FQE, 5Y5T, 3TUC, 3VF9, 6ZCS, 3EMG

ZINC - Investigational

KSYK_HUMAN

ZINC - Metabolites

KSYK_HUMAN

IntEnz

2.7.10.2

GeneCards

P43405

HPA

ENSG00000165025-SYK

Ensembl

ENSP00000364898, ENSP00000364899, ENST00000375751, ENSP00000364904, ENSP00000364907, ENST00000375747, ENSG00000165025, ENST00000375746, ENST00000375754

Pharos - Targets

P43405

ZINC - Predictions - Purchasable

KSYK_HUMAN

HMDB Protein

HMDBP01458

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.873	10
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.831	8
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.748	8
UniProt:P22681 CBL	20	CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs*16 [cytosol] (R-HSA-9706211)	0.743	7
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.737	22
UniProt:P20273 CD22	3	NAc-CD22 [plasma membrane] (R-HSA-5690736) CD22 [plasma membrane] (R-HSA-197703) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.623	4
UniProt:P07766 CD3E	2	CD3E [plasma membrane] (R-HSA-197906) p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228)	0.597	6
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.591	4
UniProt:P27986 PIK3R1	15	PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.581	5
UniProt:Q96IP4 TET5A			0.57	3
UniProt:P30273 FCER1G	5	FCER1G [tertiary granule membrane] (R-HSA-6800183) FCER1G [ficolin-1-rich granule membrane] (R-HSA-6801016) p-Y65-FCER1G [plasma membrane] (R-HSA-2454244) FCER1G [plasma membrane] (R-HSA-54715) p-Y65,Y76-FCER1G [plasma membrane] (R-HSA-141096)	0.564	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8TF42 UBS3B			0.544	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:P11049 CD37			0.499	3
ChEBI:49375 DASATINIB			0.499	2
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.462	4
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3

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