Reactome | p-Y348-SYK [cytosol]

p-Y348-SYK [cytosol]

Stable Identifier

R-HSA-437953

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-SYK(Y348), Tyrosine-protein kinase SYK , Spleen tyrosine kinase

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External Reference Information

External Reference

UniProt:P43405 SYK

Gene Names

SYK

Chain

chain:1-635

Reference Genes

BioGPS Gene:6850 SYK

COSMIC (genes):SYK SYK

CTD Gene:6850 SYK

dbSNP Gene:6850 SYK

ENSEMBL:ENSG00000165025 SYK

ENSEMBL_homo_sapiens_GENE:ENSG00000165025 SYK

HGNC:11491 SYK

KEGG Gene (Homo sapiens):6850 SYK

Monarch:6850 SYK

NCBI Gene:6850 SYK

OMIM:600085 SYK

UCSC:P43405 SYK

Reference Transcript

Other Identifiers

0003990546

04660+2.7.10.2

11719718_a_at

11754925_a_at

1384

1630_s_at

17086708

1A81

1CSY

1CSZ

1XBA

1XBB

1XBC

207540_s_at

209269_s_at

226068_at

3178954

3178955

3178958

3178959

3178960

3178961

3178964

3178965

3178969

3178971

3178972

3178973

3178977

3178980

3178982

3178984

3178986

3178989

3178994

3178995

3178996

3178997

3178998

36885_at

3BUW

3EMG

3FQE

3FQH

3FQS

3SRV

3TUB

3TUC

3TUD

3VF8

3VF9

4DFL

4DFN

4F4P

4FL1

4FL2

4FL3

4FYN

4FYO

4FZ6

4FZ7

4GFG

4I0R

4I0S

4I0T

4PUZ

4PV0

4PX6

4RSS

4RX7

4RX8

4RX9

4WNM

4XG2

4XG3

4XG4

4XG6

4XG7

4XG8

4XG9

4YJO

4YJP

4YJQ

4YJR

4YJS

4YJT

4YJU

4YJV

548_s_at

55564_at

5C26

5C27

5CXH

5CXZ

5CY3

5GHV

5LMA

5LMB

5T68

5TIU

5TR6

5TT7

5Y5T

5Y5U

6850

7773

8156321

A0A024R244

A0A024R273

A_14_P110676

A_14_P117239

A_23_P9255

AAA36526

AAH01645

AAH02962

AAH11399

AL354862

BC001645

BC002962

BC011399

CAA51970

CAA82737

CAB007773

CCDS47992

CCDS6688

CH471089

EAW62782

EAW62783

EAW62784

EAW62785

EAW62786

ENSG00000165025

ENSP00000364898

ENSP00000364899

ENSP00000364904

ENSP00000364907

ENST00000375746

ENST00000375747

ENST00000375751

ENST00000375754

EntrezGene:6850

g4507328_3p_a_at

GE57710

GO:0000166

GO:0000187

GO:0001525

GO:0001784

GO:0001820

GO:0001945

GO:0002092

GO:0002223

GO:0002250

GO:0002281

GO:0002283

GO:0002366

GO:0002376

GO:0002554

GO:0003674

GO:0004672

GO:0004674

GO:0004713

GO:0004715

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006606

GO:0006629

GO:0006810

GO:0006913

GO:0006950

GO:0007155

GO:0007159

GO:0007165

GO:0007166

GO:0007167

GO:0007229

GO:0007257

GO:0008150

GO:0008283

GO:0009058

GO:0009887

GO:0010543

GO:0010803

GO:0016020

GO:0016032

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018108

GO:0019370

GO:0019815

GO:0019899

GO:0019901

GO:0019902

GO:0030154

GO:0030168

GO:0030593

GO:0031410

GO:0031623

GO:0032009

GO:0032481

GO:0032753

GO:0032928

GO:0032991

GO:0033630

GO:0034641

GO:0035325

GO:0035556

GO:0038063

GO:0038095

GO:0038096

GO:0038110

GO:0038156

GO:0040011

GO:0042101

GO:0042169

GO:0042592

GO:0042742

GO:0043167

GO:0043226

GO:0043306

GO:0043313

GO:0043366

GO:0044281

GO:0044403

GO:0045087

GO:0045401

GO:0045425

GO:0045579

GO:0045588

GO:0045780

GO:0046638

GO:0046641

GO:0046777

GO:0048514

GO:0048646

GO:0048856

GO:0048870

GO:0050715

GO:0050731

GO:0050764

GO:0050850

GO:0050853

GO:0051090

GO:0070372

GO:0071226

GO:0071404

GO:0090237

GO:0090330

GO:0120162

HGNC:11491

HPA001384

Hs.74101.1.S2_3p_a_at

Hs.74101.2.S1_3p_a_at

Hs.74101.2.S1_3p_at

ILMN_1681350

ILMN_2059549

IPR000719

IPR000980

IPR001245

IPR008266

IPR011009

IPR012234

IPR017441

IPR020635

IPR023420

IPR035838

IPR036860

L28824

MIM:600085

NM_001135052

NM_001174167

NM_001174168

NM_003177

NP_001128524

NP_001167638

NP_001167639

NP_003168

PF00017

PF07714

PH_hs_0022924

PR00109

PR00401

S80267_s_at

SM00219

SM00252

SYK

SYK-201

SYK-202

SYK-203

SYK-204

TC09000428.hg

uc004aqz.4

uc004ara.4

uc004arb.4

uc004arc.4

UPI000002AD05

UPI000012E0DD

X73568

XM_005252147

XM_011518946

XP_005252204

XP_011517248

XR_001746370

Z29630

Participant Of

hasMember

p-Y348-SYK/LCK [cytosol]

input

p-Y348-SYK binds VAV family

hasComponent

output

p-Y348-SYK dissociates

Other forms of this molecule

p-Y-SYK [plasma membrane]

SYK [plasma membrane]

p-6Y-SYK [cytosol]

SYK [cytosol]

Inferred To

phospho-p-Y348-SYK [cytosol] (Bos taurus)

phospho-p-Y348-SYK [cytosol] (Canis familiaris)

phospho-p-Y348-SYK [cytosol] (Danio rerio)

phospho-p-Y348-SYK [cytosol] (Gallus gallus)

phospho-p-Y348-SYK [cytosol] (Mus musculus)

phospho-p-Y348-SYK [cytosol] (Rattus norvegicus)

phospho-p-Y348-SYK [cytosol] (Xenopus tropicalis)

Ghost homologue of p-Y348-SYK [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 348

Coordinate

348

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001167638.1, NP_001128524.1, NP_003168.2, XP_005252204.1, NP_001167639.1, XP_011517248.1

ZINC - World Drugs

KSYK_HUMAN

OpenTargets

ENSG00000165025

ZINC - FDA approved

KSYK_HUMAN

ZINC - Substances

KSYK_HUMAN

ZINC target

P43405

ZINC - Biogenic

KSYK_HUMAN

PRO

P43405

PDB

4I0S, 3EMG, 4I0R, 5Y5T, 6HM6, 5LMB, 4GFG, 4FYO, 4DFL, 4I0T, 5CY3, 5CXZ, 4FYN, 6HM7, 1CSY, 5CXH, 4YJV, 3TUB, 3FQS, 5TT7, 4XG8, 4WNM, 4PUZ, 4XG9, 4PV0, 4FL3, 5LMA, 4F4P, 4YJT, 3TUD, 4XG6, 4YJU, 3TUC, 1A81, 4XG7, 1CSZ, 3FQE, 4YJR, 3BUW, 4XG3, 4YJS, 4XG4, 3SRV, 4YJP, 5C27, 5T68, 4RX8, 4YJQ, 3FQH, 4FL2, 4XG2, 4RX9, 4FL1, 4PX6, 5TR6, 5TIU, 4FZ6, 3VF8, 4YJO, 5C26, 1XBA, 4DFN, 4RX7, 5Y5U, 4RSS, 1XBB, 5GHV, 1XBC, 4FZ7, 3VF9

ZINC - Metabolites

KSYK_HUMAN

GeneCards

P43405

DOCK Blaster

4FZ6, 3FQE, 3VF9, 3TUB, 4I0R, 5T68, 4GFG, 5TT7, 4WNM, 4DFN, 1XBB, 3FQH, 4YJT, 5CXZ, 4YJR, 4F4P, 4FL1, 4XG3, 4RX7, 4RX9, 5LMA, 3SRV, 4XG4, 5TIU, 4YJV, 4YJP, 4XG9, 4XG2, 4XG8, 4I0S, 3VF8, 5CXH, 4FZ7, 1A81, 3FQS, 4PX6, 4PUZ, 3TUC, 4FYN, 5C27, 4FYO, 1XBC, 5GHV, 1XBA, 5TR6, 4PV0, 4DFL, 3EMG, 4YJS, 4RSS, 5LMB, 5C26, 5CY3, 3BUW, 4RX8, 4XG6, 3TUD, 4FL3, 4YJQ, 4FL2, 4XG7, 4I0T, 4YJO, 4YJU

BRENDA (Homo sapiens)

2.7.12.1, 2.7.10.2

ZINC - Predictions - Purchasable

KSYK_HUMAN

HMDB Protein

HMDBP01458

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-S727-STAT3 [cytosol] (R-HSA-198705) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048)	0.821	8
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.764	6
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.748	8
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940)	0.743	7
UniProt:P36888 FLT3	2	FLT3 [plasma membrane] (R-HSA-6786756) Autophosphorylated FLT3 [plasma membrane] (R-HSA-9604780)	0.737	22
UniProt:P20273 CD22	3	CD22 [plasma membrane] (R-HSA-197703) NAc-CD22 [plasma membrane] (R-HSA-5690736) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.623	4
UniProt:P07766 CD3E	2	p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228) CD3E [plasma membrane] (R-HSA-197906)	0.597	6
UniProt:Q9ULZ3 PYCARD	4	PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [cytosol] (R-HSA-561191)	0.591	4
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.581	5
UniProt:Q96IP4 TET5A			0.57	3
UniProt:P30273 FCER1G	5	FCER1G [ficolin-1-rich granule membrane] (R-HSA-6801016) FCER1G [tertiary granule membrane] (R-HSA-6800183) p-Y65-FCER1G [plasma membrane] (R-HSA-2454244) FCER1G [plasma membrane] (R-HSA-54715) p-Y65,Y76-FCER1G [plasma membrane] (R-HSA-141096)	0.564	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.556	3
UniProt:Q8TF42 UBS3B			0.544	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:P11049 CD37			0.499	3
ChEBI:49375 DASATINIB			0.499	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	3
UniProt:P19174 PLCG1	6	PLCG1 [plasma membrane] (R-HSA-167682) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.462	4