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p-Y348-SYK
Stable Identifier
R-HSA-437953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-SYK(Y348), Tyrosine-protein kinase SYK , Spleen tyrosine kinase
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
Syk activation leads to SLP-76 activation (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
Syk/Lck phosphorylate LAT (Homo sapiens)
p-Y348-SYK/LCK [cytosol] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK binds VAV family (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK:VAV family [cytosol] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK dissociates (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK phosphorylates VAV family (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK:VAV family [cytosol] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK:p-VAV family [cytosol] (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43405 SYK
Gene Names
SYK
Chain
chain:1-635
Reference Genes
BioGPS Gene:6850 SYK
COSMIC (genes):SYK SYK
CTD Gene:6850 SYK
dbSNP Gene:6850 SYK
ENSEMBL:ENSG00000165025 SYK
HGNC:11491 SYK
KEGG Gene (Homo sapiens):hsa:6850 SYK
Monarch:6850 SYK
NCBI Gene:6850 SYK
OMIM:600085 SYK
UCSC:P43405 SYK
Reference Transcript
RefSeq:NM_003177.6 SYK
RefSeq:NM_001135052.3 SYK
RefSeq:NM_001174167.2 SYK
RefSeq:XM_011518946.2 SYK
RefSeq:XM_005252147.3 SYK
RefSeq:NM_001174168.2 SYK
Other Identifiers
0003990546
11719718_a_at
11754925_a_at
1384
1630_s_at
17086708
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
207540_s_at
209269_s_at
226068_at
3178954
3178955
3178958
3178959
3178960
3178961
3178964
3178965
3178969
3178971
3178972
3178973
3178977
3178980
3178982
3178984
3178986
3178989
3178994
3178995
3178996
3178997
3178998
36885_at
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
548_s_at
55564_at
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
6850
7773
7896689
7896705
8156321
A0A024R244
A0A024R273
A_14_P110676
A_14_P117239
A_23_P9255
CAB007773
CCDS47992
CCDS6688
ENSG00000165025
ENSP00000364898
ENSP00000364899
ENSP00000364904
ENSP00000364907
ENST00000375746
ENST00000375747
ENST00000375751
ENST00000375754
EntrezGene:6850
g4507328_3p_a_at
GE57710
GO:0000166
GO:0000187
GO:0001525
GO:0001784
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0004716
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006954
GO:0007159
GO:0007166
GO:0007167
GO:0007169
GO:0007229
GO:0007257
GO:0008283
GO:0009887
GO:0010543
GO:0010803
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018108
GO:0019370
GO:0019815
GO:0019901
GO:0019902
GO:0030168
GO:0030593
GO:0031234
GO:0031623
GO:0032009
GO:0032481
GO:0032928
GO:0033630
GO:0035325
GO:0035556
GO:0038063
GO:0038083
GO:0038095
GO:0038096
GO:0042101
GO:0042169
GO:0042742
GO:0042991
GO:0043234
GO:0043306
GO:0043313
GO:0043366
GO:0045087
GO:0045401
GO:0045425
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0046777
GO:0048514
GO:0050715
GO:0050731
GO:0050764
GO:0050850
GO:0050853
GO:0051090
GO:0070372
GO:0071226
GO:0071404
GO:0090237
GO:0090330
GO:1900086
HGNC:11491
HPA001384
Hs.371720
Hs.74101.1.S2_3p_a_at
Hs.74101.2.S1_3p_a_at
Hs.74101.2.S1_3p_at
ILMN_1681350
ILMN_2059549
MIM:600085
NM_001135052
NM_001174167
NM_001174168
NM_003177
NP_001128524
NP_001167638
NP_001167639
NP_003168
PF00017
PF07714
PH_hs_0022924
PR00109
PR00401
S80267_s_at
SM00219
SM00252
SYK
SYK-201
SYK-202
SYK-203
SYK-204
TC09000428.hg
uc004aqz.4
uc004ara.4
uc004arb.4
uc004arc.4
UPI000002AD05
UPI000012E0DD
XM_005252147
XM_011518946
XP_005252204
XP_011517248
XR_001746370
Participant Of
input
p-Y348-SYK binds VAV family
hasMember
p-Y348-SYK/LCK [cytosol]
hasComponent
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane]
p-Y348-SYK:p-VAV family [cytosol]
p-Y348-SYK:VAV family [cytosol]
output
p-Y348-SYK dissociates
Other forms of this molecule
p-Y-SYK [plasma membrane]
SYK [plasma membrane]
p-6Y-SYK [cytosol]
SYK [cytosol]
p-6Y-SYK [cytosol]
Inferred To
phospho-p-Y348-SYK [cytosol] (Bos taurus)
phospho-p-Y348-SYK [cytosol] (Canis familiaris)
phospho-p-Y348-SYK [cytosol] (Danio rerio)
phospho-p-Y348-SYK [cytosol] (Gallus gallus)
phospho-p-Y348-SYK [cytosol] (Mus musculus)
phospho-p-Y348-SYK [cytosol] (Rattus norvegicus)
phospho-p-Y348-SYK [cytosol] (Sus scrofa)
phospho-p-Y348-SYK [cytosol] (Taeniopygia guttata)
phospho-p-Y348-SYK [cytosol] (Xenopus tropicalis)
Homologues of p-Y348-SYK [cytosol] (Canis familiaris)
Homologues of p-Y348-SYK [cytosol] (Danio rerio)
Homologues of p-Y348-SYK [cytosol] (Rattus norvegicus)
Homologues of p-Y348-SYK [cytosol] (Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003168.2
,
XP_005252204.1
,
XP_011517248.1
,
NP_001128524.1
,
NP_001167638.1
,
NP_001167639.1
Brenda
2.7.10.2
ZINC - World Drugs
KSYK_HUMAN
ZINC - FDA approved
KSYK_HUMAN
ZINC - Substances
KSYK_HUMAN
ZINC - Biogenic
KSYK_HUMAN
ZINC target
P43405
PRO
P43405
PDB
4FZ6
,
4FZ7
,
5LMB
,
5T68
,
4GFG
,
5TIU
,
4I0R
,
5TR6
,
4I0S
,
5TT7
,
5CXZ
,
4FL2
,
5CY3
,
4FL3
,
5GHV
,
4FYN
,
5LMA
,
4FYO
,
3VF9
,
4YJV
,
4DFL
,
5C26
,
4DFN
,
5C27
,
4F4P
,
4FL1
,
5CXH
,
3TUB
,
4YJR
,
3TUC
,
4YJS
,
3TUD
,
4YJT
,
3VF8
,
4YJU
,
3FQH
,
4XG8
,
4XG9
,
3FQS
,
4YJO
,
4YJP
,
3SRV
,
4YJQ
,
4XG2
,
1XBC
,
4XG3
,
3BUW
,
4XG4
,
3EMG
,
4XG6
,
3FQE
,
4XG7
,
4RSS
,
1A81
,
4PX6
,
4PV0
,
4PUZ
,
4I0T
,
1XBB
,
4WNM
,
1XBA
,
4RX9
,
4RX8
,
1CSZ
,
4RX7
,
1CSY
ZINC - Metabolites
KSYK_HUMAN
GeneCards
P43405
DOCK Blaster
3VF8
,
4FYO
,
3VF9
,
4FZ6
,
4FZ7
,
3SRV
,
4FYN
,
1A81
,
4DFL
,
3TUD
,
3TUB
,
4PUZ
,
3TUC
,
4PX6
,
4I0R
,
4PV0
,
4DFN
,
5GHV
,
3FQE
,
5CXH
,
4FL1
,
5T68
,
5CXZ
,
5CY3
,
4I0S
,
4I0T
,
4F4P
,
1XBC
,
3FQS
,
1XBA
,
1XBB
,
4FL2
,
4RX7
,
4FL3
,
4WNM
,
4RX8
,
4RX9
,
3FQH
,
4YJU
,
4YJV
,
4YJO
,
4YJP
,
3EMG
,
4YJQ
,
4YJR
,
4YJS
,
4YJT
,
5TT7
,
5TIU
,
3BUW
,
4GFG
,
4XG2
,
4RSS
,
5C26
,
4XG9
,
4XG8
,
5C27
,
4XG7
,
4XG6
,
4XG4
,
5LMA
,
5LMB
,
4XG3
,
5TR6
ZINC - Predictions - Purchasable
KSYK_HUMAN
HMDB Protein
HMDBP01458
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
0.821
8
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.764
6
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.748
8
UniProt:P22681 CBL
7
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
CBL [plasma membrane]
(R-HSA-112192)
0.743
7
UniProt:P36888 FLT3
1
FLT3 [plasma membrane]
(R-HSA-6786756)
0.644
21
UniProt:P20273 CD22
3
CD22 [plasma membrane]
(R-HSA-197703)
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.623
4
UniProt:P07766 CD3E
2
p-Y188,Y199-CD3E [plasma membrane]
(R-HSA-202228)
CD3E [plasma membrane]
(R-HSA-197906)
0.597
6
UniProt:Q9ULZ3 PYCARD
4
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [cytosol]
(R-HSA-561191)
0.591
4
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.581
5
UniProt:Q96IP4 FA46A
0.57
3
UniProt:P30273 FCER1G
5
FCER1G [tertiary granule membrane]
(R-HSA-6800183)
FCER1G [ficolin-1-rich granule membrane]
(R-HSA-6801016)
p-Y65-FCER1G [plasma membrane]
(R-HSA-2454244)
FCER1G [plasma membrane]
(R-HSA-54715)
p-Y65,Y76-FCER1G [plasma membrane]
(R-HSA-141096)
0.564
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.556
3
UniProt:Q8TF42 UBS3B
0.544
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:P11049 CD37
0.499
3
ChEBI:49375 DASATINIB
0.499
2
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y-PLCG1 [plasma membrane]
(R-HSA-593686)
0.462
4
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
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