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SRPK2 [cytosol]
Stable Identifier
R-HSA-9729332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SRSF protein kinase 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
SRPK1/2 [cytosol] (Homo sapiens)
SRPK2:Mg2+ [cytosol] (Homo sapiens)
SRPK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78362 SRPK2
Gene Names
SRPK2
Chain
chain:1-688, chain:1-139, chain:140-688
Reference Genes
BioGPS Gene:6733 SRPK2
COSMIC (genes):SRPK2 SRPK2
CTD Gene:6733 SRPK2
dbSNP Gene:6733 SRPK2
ENSEMBL:ENSG00000135250 SRPK2
HGNC:11306 SRPK2
KEGG Gene (Homo sapiens):6733 SRPK2
Monarch:6733 SRPK2
NCBI Gene:6733 SRPK2
OMIM:602980 SRPK2
UCSC:P78362 SRPK2
Reference Transcript
RefSeq:XM_017012566.1 SRPK2
RefSeq:NM_182692.2 SRPK2
RefSeq:NM_182691.2 SRPK2
RefSeq:NM_001278273.1 SRPK2
Other Identifiers
0000840044
0003390180
0100770278
11721820_a_at
11721821_a_at
11754831_a_at
1213_at
1558254_s_at
17061433
203181_x_at
203182_s_at
214931_s_at
230091_at
3066301
3066302
3066303
3066304
3066305
3066306
3066307
3066308
3066309
3066318
3066319
3066323
3066324
3066325
3066330
3066331
3066333
3066334
3066335
3066343
3066344
3066350
3066351
3066352
3066353
3066362
3066363
3066374
3066375
3066376
3066377
3066381
3066382
3066400
3066401
3100869
3100873
3137849
37409_at
6733
8142036
91778_s_at
A_23_P215599
A_23_P406438
GE59523
GO:0000166
GO:0000245
GO:0000287
GO:0000785
GO:0001525
GO:0002376
GO:0003674
GO:0003723
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006259
GO:0006397
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008380
GO:0009058
GO:0010628
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0022607
GO:0022618
GO:0030154
GO:0034641
GO:0035063
GO:0035556
GO:0043167
GO:0043226
GO:0043525
GO:0044403
GO:0045070
GO:0045071
GO:0045087
GO:0045787
GO:0048024
GO:0048646
GO:0048856
GO:0050684
GO:0062176
GO:0065003
GO:0071889
GO:0106310
GO:0106311
HMNXSV003058020
Hs.78353.0.A1_3p_a_at
Hs.78353.1.A1_3p_at
Hs.78353.2.A1_3p_a_at
Hs2.380021.1.S1_3p_s_at
ILMN_1657451
ILMN_1669215
ILMN_1695468
PH_hs_0023115
TC07001731.hg
U88666_at
g4507220_3p_a_at
Participates
as a component of
SRPK2:Mg2+ [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 52
Coordinate
52
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 588
Coordinate
588
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001265202.1
,
NP_872633.1
,
NP_872634.1
,
XP_016868055.1
ZINC - World Drugs
SRPK2_HUMAN
Guide to Pharmacology - Targets
2209
OpenTargets
ENSG00000135250
ZINC - FDA approved
SRPK2_HUMAN
ZINC - Substances
SRPK2_HUMAN
ZINC target
P78362
ZINC - Biogenic
SRPK2_HUMAN
PRO
P78362
GlyGen
P78362
PDB
5MYV
,
2X7G
ZINC - Investigational
SRPK2_HUMAN
GeneCards
P78362
HPA
ENSG00000135250-SRPK2
Ensembl
ENSP00000349863
,
ENSG00000135250
,
ENSP00000377262
,
ENSP00000419791
,
ENST00000489828
,
ENST00000357311
,
ENST00000393651
Pharos - Targets
P78362
ZINC - Predictions - Purchasable
SRPK2_HUMAN
HMDB Protein
HMDBP08814
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.811
6
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.806
6
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.788
7
UniProt:P62995 TRA2B
2
TRA2B [nucleoplasm]
(R-HSA-8850859)
TRA2B [cytosol]
(R-HSA-9715137)
0.756
5
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.754
5
UniProt:P26368 U2AF2
1
U2AF2 [nucleoplasm]
(R-HSA-71987)
0.748
5
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.59
2
UniProt:Q13243 SRSF5
1
SRSF5 [nucleoplasm]
(R-HSA-72028)
0.59
2
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.59
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.59
2
UniProt:O75494 SRSF10
1
SRSF10 [nucleoplasm]
(R-HSA-8866646)
0.59
2
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.59
2
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9UKV3 ACIN1
3
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
0.547
2
UniProt:Q01130 SRSF2
1
SRSF2 [nucleoplasm]
(R-HSA-72033)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q13247 SRSF6
1
SRSF6 [nucleoplasm]
(R-HSA-72026)
0.527
2
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.527
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.525
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.525
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.482
2
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