Reactome | SRPK2 [cytosol]

SRPK2 [cytosol]

Stable Identifier

R-HSA-9729332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SRSF protein kinase 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of nucleoprotein (Homo sapiens)
        
        SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
        
        SRPK1/2 [cytosol] (Homo sapiens)
        
        SRPK2:Mg2+ [cytosol] (Homo sapiens)
        
        SRPK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78362 SRPK2

Gene Names

SRPK2

Chain

chain:1-688, chain:1-139, chain:140-688

Reference Genes

BioGPS Gene:6733 SRPK2

COSMIC (genes):SRPK2 SRPK2

CTD Gene:6733 SRPK2

dbSNP Gene:6733 SRPK2

ENSEMBL:ENSG00000135250 SRPK2

ENSEMBL_homo_sapiens_GENE:ENSG00000135250.17 SRPK2

HGNC:11306 SRPK2

KEGG Gene (Homo sapiens):6733 SRPK2

Monarch:6733 SRPK2

NCBI Gene:6733 SRPK2

OMIM:602980 SRPK2

UCSC:P78362 SRPK2

Reference Transcript

Other Identifiers

11721820_a_at

11721821_a_at

11754831_a_at

1213_at

1558254_PM_s_at

1558254_s_at

17061433

203181_PM_x_at

203181_x_at

203182_PM_s_at

203182_s_at

214931_PM_s_at

214931_s_at

230091_PM_at

230091_at

3066301

3066302

3066303

3066304

3066305

3066306

3066307

3066308

3066309

3066318

3066319

3066323

3066324

3066325

3066330

3066331

3066333

3066334

3066335

3066343

3066344

3066350

3066351

3066352

3066353

3066362

3066363

3066374

3066375

3066376

3066377

3066381

3066382

3066400

3066401

3100869

3100873

3137849

37409_at

6733

8142036

91778_s_at

A_23_P215599

A_23_P406438

GE59523

GO:0000166

GO:0000245

GO:0000287

GO:0000785

GO:0001525

GO:0002376

GO:0003723

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006325

GO:0006397

GO:0006468

GO:0008284

GO:0008380

GO:0010628

GO:0012501

GO:0016071

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0023052

GO:0030154

GO:0035063

GO:0035556

GO:0036211

GO:0043226

GO:0043525

GO:0045070

GO:0045071

GO:0045087

GO:0045787

GO:0048024

GO:0048856

GO:0050684

GO:0062176

GO:0065003

GO:0071889

GO:0098542

GO:0106310

GO:0140096

Hs.78353.0.A1_3p_a_at

Hs.78353.1.A1_3p_at

Hs.78353.2.A1_3p_a_at

Hs2.380021.1.S1_3p_s_at

ILMN_1657451

ILMN_1669215

ILMN_1695468

PH_hs_0023115

TC07001731.hg

U88666_at

g4507220_3p_a_at

Participates

as a component of

SRPK2:Mg2+ [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 52

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 588

Coordinate

588

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016868055.1, NP_872634.1, NP_872633.1, NP_001265202.1

ZINC - World Drugs

SRPK2_HUMAN

Guide to Pharmacology - Targets

2209

OpenTargets

ENSG00000135250

ZINC - FDA approved

SRPK2_HUMAN

ZINC - Substances

SRPK2_HUMAN

ZINC - Biogenic

SRPK2_HUMAN

ZINC target

P78362

PRO

P78362

PDB

5MYV, 2X7G, 7ZKX

ZINC - Investigational

SRPK2_HUMAN

HPA

ENSG00000135250-SRPK2

GeneCards

P78362

Ensembl

ENST00000393651, ENSP00000377262, ENST00000489828, ENST00000357311, ENSP00000349863, ENSG00000135250, ENSP00000419791

Pharos - Targets

P78362

ZINC - Predictions - Purchasable

SRPK2_HUMAN

HMDB Protein

HMDBP08814

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.837	10
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.811	6
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.788	7
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.754	5
UniProt:P26368 U2AF2	2	5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011) U2AF2 [nucleoplasm] (R-HSA-71987)	0.748	5
UniProt:Q8IYB3 SRRM1	2	SRRM1 [nucleoplasm] (R-HSA-156781) SRRM1 [cytosol] (R-HSA-159255)	0.613	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.59	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.59	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.59	2
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.59	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.59	2
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.547	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.547	2
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q13247 SRSF6	1	SRSF6 [nucleoplasm] (R-HSA-72026)	0.527	2
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:O95232 LUC7L3	1	LUC7L3 [nucleoplasm] (R-HSA-9770258)	0.527	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.525	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.525	2
UniProt:Q86UR5 RIMS1	1	RIMS1 [cytosol] (R-HSA-210407)	0.499	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.482	2

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