Reactome | PPP2CA [nucleoplasm]

PPP2CA [nucleoplasm]

Stable Identifier

R-HSA-165978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-catalytic subunit C alpha isoform

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

BioGPS Gene:5515 PPP2CA

COSMIC (genes):PPP2CA PPP2CA

CTD Gene:5515 PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575.10 PPP2CA

HGNC:9299 PPP2CA

KEGG Gene (Homo sapiens):5515 PPP2CA

Monarch:5515 PPP2CA

NCBI Gene:5515 PPP2CA

OMIM:176915 PPP2CA

UCSC:P67775 PPP2CA

Reference Transcript

RefSeq:NM_002715.2 PPP2CA

Other Identifiers

0000360079

11715804_s_at

11715805_a_at

11758731_at

17000022

208652_PM_at

208652_at

235502_PM_at

235502_at

237_s_at

238719_PM_at

238719_at

2876044

2876045

2876047

2876048

2876049

2876050

2876051

2876052

2876053

2876054

2876055

2876056

2876058

2876060

2876061

2876062

2876066

2876067

2876075

2876076

2876077

2876078

33181_at

48243_at

54851_at

5515

8114158

A_23_P122041

GE57999

GO:0000159

GO:0000278

GO:0000775

GO:0000922

GO:0001932

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0006260

GO:0006275

GO:0006351

GO:0006355

GO:0006470

GO:0006629

GO:0006672

GO:0006915

GO:0007155

GO:0007498

GO:0008022

GO:0008092

GO:0008380

GO:0010033

GO:0010288

GO:0010719

GO:0012501

GO:0015630

GO:0016020

GO:0016787

GO:0017018

GO:0019932

GO:0022414

GO:0023052

GO:0030111

GO:0030154

GO:0030155

GO:0030308

GO:0032991

GO:0035970

GO:0036211

GO:0040008

GO:0042532

GO:0043226

GO:0045121

GO:0045202

GO:0045595

GO:0046872

GO:0046982

GO:0048156

GO:0048856

GO:0050811

GO:0051321

GO:0051898

GO:0070062

GO:0070262

GO:0071902

GO:0140096

GO:1904526

GO:1904528

GO:2000045

HMNXSV003012706

Hs.102243.0.A1_3p_at

Hs.102243.0.A1_3p_x_at

Hs.79204.0.S1_3p_at

ILMN_1722858

ILMN_2196097

M60483_rna1_s_at

PH_hs_0005098

TC05003406.hg

g12653262_3p_at

Participates

as a candidate of

PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MeL-PPP2CA [nucleoplasm]

p-Y307-PPP2CA [cytosol]

PPP2CA [cytosol]

Inferred To

csf1 [nucleoplasm] (Xenopus tropicalis)

ppp2ca [nucleoplasm] (Danio rerio)

PPP2CA [nucleoplasm] (Bos taurus)

PPP2CA [nucleoplasm] (Caenorhabditis elegans)

PPP2CA [nucleoplasm] (Canis familiaris)

PPP2CA [nucleoplasm] (Dictyostelium discoideum)

PPP2CA [nucleoplasm] (Drosophila melanogaster)

PPP2CA [nucleoplasm] (Gallus gallus)

PPP2CA [nucleoplasm] (Mus musculus)

PPP2CA [nucleoplasm] (Rattus norvegicus)

PPP2CA [nucleoplasm] (Saccharomyces cerevisiae)

PPP2CA [nucleoplasm] (Schizosaccharomyces pombe)

PPP2CA [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002706.1

OpenTargets

ENSG00000113575

HPA

ENSG00000113575-PPP2CA

GeneCards

P67775

Ensembl

ENSG00000113575, ENSP00000418447, ENST00000481195

ZINC target

P67775

PRO

P67775

Pharos - Targets

P67775

HMDB Protein

HMDBP02514

PDB

2NPP, 2NYM, 4LAC, 5W0W, 2IE4, 7K36, 2NYL, 3K7V, 2IE3, 4IYP, 3FGA, 6NTS, 7PKS, 3P71, 3C5W, 3K7W, 4I5N, 2IAE, 4NY3, 7CUN, 3DW8, 4I5L

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.836	6
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.788	6
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.756	4
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.737	5
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.69	4
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.643	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.643	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.641	3
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.641	4
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.591	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:P04049 RAF1	20	RAF1 [cytosol] (R-HSA-167205) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134)	0.544	2
UniProt:Q86XL3 ANKLE2	2	ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000) Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946)	0.527	2
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.527	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.499	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.462	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.462	2