Reactome | PPP2CA [nucleoplasm]

PPP2CA [nucleoplasm]

Stable Identifier

R-HSA-165978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-catalytic subunit C alpha isoform

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

BioGPS Gene:5515 PPP2CA

COSMIC (genes):PPP2CA PPP2CA

CTD Gene:5515 PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575 PPP2CA

HGNC:9299 PPP2CA

KEGG Gene (Homo sapiens):5515 PPP2CA

Monarch:5515 PPP2CA

NCBI Gene:5515 PPP2CA

OMIM:176915 PPP2CA

UCSC:P67775 PPP2CA

Reference Transcript

RefSeq:NM_002715.2 PPP2CA

Other Identifiers

0000360079

04658+3.1.3.16

04660+3.1.3.16

05235+3.1.3.16

11715804_s_at

11715805_a_at

11758731_at

17000022

208652_at

235502_at

237_s_at

238719_at

2876044

2876045

2876047

2876048

2876049

2876050

2876051

2876052

2876053

2876054

2876055

2876056

2876058

2876060

2876061

2876062

2876066

2876067

2876075

2876076

2876077

2876078

2IAE

2IE3

2IE4

2NPP

2NYL

2NYM

33181_at

3848

3C5W

3DW8

3FGA

3K7V

3K7W

3P71

43236

48243_at

4I5L

4I5N

4IYP

4LAC

54851_at

5515

5W0W

8114158

A_23_P122041

A_24_P183375

AAA36466

AAB38019

AAH00400

AAH02657

AAH19275

AAH31696

AB451240

AB451365

AK097599

B3KUN1

BAG53493

BAG70054

BAG70179

BC000400

BC002657

BC019275

BC031696

CAA31176

CAB003848

CCDS4173

CH471062

E5RHP4

E7ESG8

EAW62268

EAW62269

ENSG00000113575

ENSP00000418447

ENST00000481195

ENST00000481195.5

EntrezGene:5515

EntrezGene:PPP2CA

g12653262_3p_at

GE57999

GO:0000003

GO:0000159

GO:0000184

GO:0000188

GO:0000278

GO:0000775

GO:0000922

GO:0001932

GO:0003674

GO:0004721

GO:0004722

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0006275

GO:0006355

GO:0006464

GO:0006470

GO:0006629

GO:0006672

GO:0006915

GO:0007049

GO:0007084

GO:0007155

GO:0007165

GO:0007267

GO:0007498

GO:0008022

GO:0008092

GO:0008150

GO:0008219

GO:0008380

GO:0009056

GO:0009058

GO:0010033

GO:0010288

GO:0010719

GO:0015630

GO:0016020

GO:0016787

GO:0016791

GO:0019932

GO:0030111

GO:0030154

GO:0030155

GO:0030308

GO:0032991

GO:0034641

GO:0034655

GO:0035970

GO:0040007

GO:0040008

GO:0042532

GO:0043167

GO:0043226

GO:0045121

GO:0045202

GO:0045595

GO:0046872

GO:0046982

GO:0048156

GO:0048856

GO:0050811

GO:0051321

GO:0061024

GO:0070062

GO:0070262

GO:0071902

GO:1904526

GO:1904528

HGNC:9299

HPA043236

Hs.102243.0.A1_3p_at

Hs.102243.0.A1_3p_x_at

Hs.79204.0.S1_3p_at

ILMN_1722858

ILMN_2196097

IPR004843

IPR006186

IPR029052

J03804

M60483

M60483_rna1_s_at

MIM:176915

MIM:618354

NM_001355019

NM_002715

NP_001341948

NP_002706

PF00149

PH_hs_0005098

PPP2CA

PPP2CA-203

PR00114

SM00156

TC05003406.hg

UPI0000000C15

X12646

Participant Of

hasCandidate

PP2A-catalytic subunit C [nucleoplasm]

Other forms of this molecule

PPP2CA [cytosol]

MeL-PPP2CA [nucleoplasm]

p-Y307-PPP2CA [cytosol]

Inferred To

PPP2CA [nucleoplasm] (Bos taurus)

PPP2CA [nucleoplasm] (Caenorhabditis elegans)

PPP2CA [nucleoplasm] (Danio rerio)

PPP2CA [nucleoplasm] (Dictyostelium discoideum)

PPP2CA [nucleoplasm] (Drosophila melanogaster)

PPP2CA [nucleoplasm] (Gallus gallus)

PPP2CA [nucleoplasm] (Mus musculus)

PPP2CA [nucleoplasm] (Rattus norvegicus)

PPP2CA [nucleoplasm] (Saccharomyces cerevisiae)

PPP2CA [nucleoplasm] (Schizosaccharomyces pombe)

PPP2CA [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002706.1

OpenTargets

ENSG00000113575

GeneCards

P67775

ZINC target

P67775

PRO

P67775

HMDB Protein

HMDBP02514

PDB

4IYP, 2NYL, 2IE3, 4I5N, 2NPP, 5W0W, 2IE4, 3K7V, 2NYM, 3K7W, 2IAE, 4I5L, 3C5W, 3DW8, 3P71, 4LAC, 3FGA

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.788	5
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.756	4
UniProt:O43815 STRN	1	STRN [cytosol] (R-HSA-9037081)	0.737	5
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.725	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.69	4
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512)	0.643	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.641	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397)	0.641	4
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642)	0.591	6
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.544	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:Q9P289 STK26	3	MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918) MST4(306-416) [cytosol] (R-HSA-351903)	0.527	2
UniProt:Q9Y6E0 STK24	4	STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.527	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.462	2
UniProt:Q14674 ESPL1	4	ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.462	2