Reactome | PPP2CA [nucleoplasm]

PPP2CA [nucleoplasm]

Stable Identifier

R-HSA-165978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-catalytic subunit C alpha isoform

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)
        
        PPP2CA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

BioGPS Gene:5515 PPP2CA

COSMIC (genes):PPP2CA PPP2CA

CTD Gene:5515 PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575 PPP2CA

HGNC:9299 PPP2CA

KEGG Gene (Homo sapiens):5515 PPP2CA

Monarch:5515 PPP2CA

NCBI Gene:5515 PPP2CA

OMIM:176915 PPP2CA

UCSC:P67775 PPP2CA

Reference Transcript

RefSeq:NM_002715.2 PPP2CA

Other Identifiers

0000360079

11715804_s_at

11715805_a_at

11758731_at

17000022

208652_at

235502_at

237_s_at

238719_at

2876044

2876045

2876047

2876048

2876049

2876050

2876051

2876052

2876053

2876054

2876055

2876056

2876058

2876060

2876061

2876062

2876066

2876067

2876075

2876076

2876077

2876078

33181_at

48243_at

54851_at

5515

8114158

A_23_P122041

A_24_P183375

GE57999

GO:0000003

GO:0000159

GO:0000184

GO:0000188

GO:0000278

GO:0000775

GO:0000922

GO:0001932

GO:0003674

GO:0004721

GO:0004722

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0006275

GO:0006355

GO:0006464

GO:0006470

GO:0006629

GO:0006672

GO:0006915

GO:0007049

GO:0007084

GO:0007155

GO:0007165

GO:0007267

GO:0007498

GO:0008022

GO:0008092

GO:0008150

GO:0008219

GO:0008380

GO:0009056

GO:0009058

GO:0010033

GO:0010288

GO:0010719

GO:0015630

GO:0016020

GO:0016787

GO:0016791

GO:0019932

GO:0030111

GO:0030154

GO:0030155

GO:0030308

GO:0032991

GO:0034641

GO:0034655

GO:0035970

GO:0040007

GO:0040008

GO:0042532

GO:0043167

GO:0043226

GO:0045121

GO:0045202

GO:0045595

GO:0046872

GO:0046982

GO:0048156

GO:0048856

GO:0050811

GO:0051321

GO:0061024

GO:0070062

GO:0070262

GO:0071902

GO:0106306

GO:0106307

GO:0140014

GO:1904526

GO:1904528

HMNXSV003012706

Hs.102243.0.A1_3p_at

Hs.102243.0.A1_3p_x_at

Hs.79204.0.S1_3p_at

ILMN_1722858

ILMN_2196097

M60483_rna1_s_at

PH_hs_0005098

TC05003406.hg

g12653262_3p_at

Participates

as a candidate of

PP2A-catalytic subunit C [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-Y307-PPP2CA [cytosol]

PPP2CA [cytosol]

MeL-PPP2CA [nucleoplasm]

Inferred To

pho2a [nucleoplasm] (Dictyostelium discoideum)

ppp2caa [nucleoplasm] (Danio rerio)

Ppp2ca [nucleoplasm] (Mus musculus)

Ppp2ca [nucleoplasm] (Rattus norvegicus)

PPP2CA [nucleoplasm] (Bos taurus)

PPP2CA [nucleoplasm] (Canis familiaris)

PPP2CA [nucleoplasm] (Gallus gallus)

mts [nucleoplasm] (Drosophila melanogaster)

ppa2 [nucleoplasm] (Schizosaccharomyces pombe)

let-92 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002706.1

OpenTargets

ENSG00000113575

HPA

ENSG00000113575-PPP2CA

GeneCards

P67775

Ensembl

ENSG00000113575, ENSP00000418447, ENST00000481195

ZINC target

P67775

PRO

P67775

Pharos - Targets

P67775

GlyGen

P67775

HMDB Protein

HMDBP02514

PDB

2NYM, 6NTS, 3K7V, 2IE3, 4IYP, 3FGA, 2IE4, 7CUN, 4I5N, 2NYL, 2NPP, 3C5W, 2IAE, 3K7W, 3DW8, 5W0W, 3P71, 4I5L, 4LAC

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.788	5
UniProt:P31749 AKT1	13	AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252)	0.756	4
UniProt:O43815 STRN	5	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN [cytosol] (R-HSA-9037081)	0.737	5
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.725	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.69	4
UniProt:O15169 AXIN1	11	AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 Y346* [cytosol] (R-HSA-4839753) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.643	4
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB [cytosol] (R-HSA-168114)	0.641	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG E391* [cytosol] (R-HSA-5262924) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG R173G [cytosol] (R-HSA-5262966)	0.641	4
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	6	SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.591	6
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.544	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:Q9Y6E0 STK24	4	STK24(314-443) [cytosol] (R-HSA-351898) STK24 [cytosol] (R-HSA-351829) STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(1-313) [cytosol] (R-HSA-351892)	0.527	2
UniProt:Q9P289 STK26	3	MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918) MST4(306-416) [cytosol] (R-HSA-351903)	0.527	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:Q14653 IRF3	4	p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3 [cytosol] (R-HSA-166251) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.499	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.462	2
UniProt:Q14674 ESPL1	4	ESPL1 [cytosol] (R-HSA-1638167) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1-1506) [cytosol] (R-HSA-2467768)	0.462	2

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