Reactome | HTT [nucleoplasm]

HTT [nucleoplasm]

Stable Identifier

R-HSA-9023590

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Huntingtin

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 binds HTT (Homo sapiens)
        
        HTT [nucleoplasm] (Homo sapiens)
        
        MECP2:HTT [plasma membrane] (Homo sapiens)
        
        HTT [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42858 HTT

Gene Names

HTT, HD, IT15

Chain

chain:1-3142, chain:551-584

Reference Genes

BioGPS Gene:3064 HTT

COSMIC (genes):HTT HTT

CTD Gene:3064 HTT

dbSNP Gene:3064 HTT

ENSEMBL:ENSG00000197386 HTT

ENSEMBL_homo_sapiens_GENE:ENSG00000197386.14 HTT

HGNC:4851 HTT

KEGG Gene (Homo sapiens):3064 HTT

Monarch:3064 HTT

NCBI Gene:3064 HTT

OMIM:613004 HTT

UCSC:P42858 HTT

Reference Transcript

RefSeq:NM_002111.8 HTT

Other Identifiers

11719967_at

11719968_at

16964316

202389_PM_s_at

202389_s_at

202390_PM_s_at

202390_s_at

2715821

2715822

2715823

2715824

2715827

2715828

2715829

2715830

2715832

2715833

2715838

2715839

2715841

2715843

2715846

2715849

2715850

2715852

2715853

2715854

2715855

2715857

2715859

2715860

2715863

2715864

2715867

2715868

2715869

2715872

2715873

2715874

2715875

2715876

2715879

2715880

2715883

2715884

2715885

2715886

2715887

2715889

2715891

2715892

2715893

2715894

2715896

2715898

2715899

2715901

2715902

2715903

2715904

2715908

2715909

2715914

2715915

2715917

2715918

2715919

2715921

2715925

2715926

2715927

2715928

2715930

2715931

2715932

2715934

2715935

2715936

2715938

2715941

2715942

2715944

2715946

2715947

2715951

2715953

2715955

2715956

2715957

2715963

2715964

2715966

2715967

2715969

2715970

2715974

2715975

2715976

2715977

2715978

2715979

2715980

2715981

2715982

2715983

2715990

2715992

2715993

2715994

2715995

2715996

2715997

3064

37767_at

8093685

A_14_P121106

A_14_P129619

A_23_P212749

A_24_P180225

GE58274

GO:0000132

GO:0000278

GO:0002039

GO:0005515

GO:0005522

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005776

GO:0005783

GO:0005794

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006890

GO:0006914

GO:0006915

GO:0007005

GO:0007010

GO:0007018

GO:0007030

GO:0007163

GO:0008092

GO:0012501

GO:0016192

GO:0016234

GO:0019900

GO:0023052

GO:0030424

GO:0030425

GO:0030659

GO:0031072

GO:0031410

GO:0031587

GO:0031648

GO:0032991

GO:0034452

GO:0036211

GO:0042297

GO:0042802

GO:0043065

GO:0043226

GO:0043666

GO:0044325

GO:0044782

GO:0045505

GO:0045724

GO:0047496

GO:0048471

GO:0048487

GO:0050877

GO:0055065

GO:0055085

GO:0099111

GO:0099523

GO:0099524

GO:1901526

GO:1904504

GO:1905289

GO:1905337

GO:2000479

GO:2001237

HMNXSV003027860

L12392_at

PH_hs_0025580

TC04000044.hg

g1709991_3p_a_at

g4755137_3p_a_at

Participates

as a component of

MECP2:HTT [plasma membrane] (Homo sapiens)

as an input of

MECP2 binds HTT (Homo sapiens)

Cross References

RefSeq

NP_002102.4

OpenTargets

ENSG00000197386

ZINC - Substances

HD_HUMAN

HPA

ENSG00000197386-HTT

GeneCards

P42858

Ensembl

ENSP00000347184, ENST00000355072, ENSG00000197386

ZINC target

P42858

PRO

P42858

Pharos - Targets

P42858

Orphanet

16190

ZINC - Predictions - Purchasable

HD_HUMAN

PDB

8W15, 7DXJ, 4FE8, 6RMH, 4RAV, 7DXK, 3LRH, 6EZ8, 3IOW, 2LD2, 3IO6, 8SAH, 3IOT, 8VLX, 4FEC, 6YEJ, 3IOU, 6X9O, 4FED, 2LD0, 3IO4, 3IOV, 6N8C, 3IOR, 4FEB

Interactors (883)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.889	11
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.824	15
UniProt:Q8IUH5 ZDH17			0.809	30
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.806	7
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.771	11
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [cytosol] (R-HSA-380285)	0.766	8
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.766	15
UniProt:O75400 PRPF40A	1	PRPF40A [nucleoplasm] (R-HSA-8867890)	0.743	15
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.743	9
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.742	26
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.742	14
UniProt:O14645 IDLC			0.742	15
UniProt:Q96K21 ANCHR			0.742	21
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.742	6
UniProt:Q9BVL2 NUP58			0.742	7
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.742	24
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.742	24
UniProt:Q99689 FEZ1			0.721	6
UniProt:P54257-2 HAP1			0.715	8
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.709	19
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.703	6
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) CRMP1 [cytosol] (R-HSA-398120) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779)	0.703	14
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.703	9
UniProt:Q96HT8 MR1L1			0.703	21
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.703	20
UniProt:Q2NKX8 ERCC6L	1	ERCC6L [cytosol] (R-HSA-376250)	0.703	20
UniProt:P02792 FTL	4	FTL [azurophil granule lumen] (R-HSA-6799149) FTL [cytosol] (R-HSA-434215) FTL [endocytic vesicle lumen] (R-HSA-2299671) FTL [extracellular region] (R-HSA-2187214)	0.703	20
UniProt:Q9H4A5 GLP3L			0.703	20
UniProt:P35080 PFN2	1	PFN2 [cytosol] (R-HSA-3009037)	0.703	7
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.703	21
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.703	20
UniProt:P54256 HAP1			0.681	3
UniProt:O95243-2 MBD4			0.675	19
UniProt:G3V1X1 G3V1X1			0.675	5
UniProt:Q9UI08-2 EVL			0.675	20
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.675	14
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.675	4
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.675	20
UniProt:P50221 MEOX1			0.675	19
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.675	22
UniProt:P23610 HAP40			0.675	4
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.675	7
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.666	7
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.666	4
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.666	7
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.666	9
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.666	10
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.666	12
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.666	13
UniProt:Q02447 SP3	3	monoSUMO1-K551-SP3 [nucleoplasm] (R-HSA-3247472) polySUMO2-K551-SP3 [nucleoplasm] (R-HSA-6804456) SP3 [nucleoplasm] (R-HSA-2160951)	0.666	4
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.666	4
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.666	14
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.666	22
UniProt:Q13347 EIF3I	1	EIF3I [cytosol] (R-HSA-72536)	0.666	13
UniProt:P25789 PSMA4	2	PSMA4 [nucleoplasm] (R-HSA-174324) PSMA4 [cytosol] (R-HSA-68730)	0.666	4
UniProt:Q96EY1 DNJA3			0.666	5
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.666	7
UniProt:P50502 ST13	1	ST13 [cytosol] (R-HSA-5255410)	0.666	13
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.666	12
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.666	10
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-199233) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-54659)	0.666	13
UniProt:P12074 COX6A1	1	COX6A1 [mitochondrial inner membrane] (R-HSA-164301)	0.666	4
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.666	22
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.666	7
UniProt:Q96M27 PRRC1			0.666	7
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.666	4
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.666	10
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [tertiary granule membrane] (R-HSA-6800175)	0.666	6
UniProt:P51674 GPM6A			0.666	4
UniProt:Q96M61 MAGBI			0.666	16
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.666	7
UniProt:Q92890 UFD1L	2	UFD1L [nucleoplasm] (R-HSA-5654993) UFD1 [cytosol] (R-HSA-9668519)	0.666	7
UniProt:Q9UK41 VPS28	1	VPS28 [endosome membrane] (R-HSA-184342)	0.666	16
UniProt:P10606 COX5B	1	COX5B [mitochondrial inner membrane] (R-HSA-164307)	0.666	7
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.666	10
UniProt:P78406 RAE1	1	RAE1 [nuclear envelope] (R-HSA-157718)	0.666	4
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.666	7
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.666	4
UniProt:Q8N9I0 SYT2	3	SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.666	10
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.666	4
UniProt:P08574 CYC1	3	CYC1(1-325) [mitochondrial intermembrane space] (R-HSA-1267962) CYC1(1-325) [cytosol] (R-HSA-1267995) CYC1 [mitochondrial inner membrane] (R-HSA-164277)	0.666	7
UniProt:P09669 COX6C	2	COX6C(3-75) [mitochondrial inner membrane] (R-HSA-164298) COX6C(3-75) [mitochondrial intermembrane space] (R-HSA-9865411)	0.666	4
UniProt:Q9H000 MKRN2			0.666	12
UniProt:Q9NNZ3 DNJC4			0.666	12
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.666	4
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.666	4
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.666	10
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.666	7
UniProt:O43813 LANC1			0.666	10
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.666	16
UniProt:O75409 HYPM			0.666	16
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.666	16
UniProt:Q16795 NDUFA9	1	NDUFA9 [mitochondrial matrix] (R-HSA-163942)	0.666	7
UniProt:Q9Y605 MOFA1			0.666	19
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.666	10
UniProt:Q9NX55 HYPK			0.666	4
UniProt:P24534 EEF1B2	1	EEF1B2 [cytosol] (R-HSA-156926)	0.666	7
UniProt:Q8TEX9 IPO4			0.666	7
UniProt:O43248 HOXC11	1	HOXC11 [nucleoplasm] (R-HSA-9830941)	0.666	7
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.666	5
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.666	10
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.666	12
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.666	11
UniProt:O43447 PPIH	2	PPIH [nucleoplasm] (R-HSA-6806776) PPIH [cytosol] (R-HSA-9728791)	0.666	10
UniProt:O14901 KLF11			0.666	7
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.666	16
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [plasma membrane] (R-HSA-164347) GNB1 [cytosol] (R-HSA-6814412)	0.666	10
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.666	10
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.666	10
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.666	4
UniProt:Q96N16 JKIP1			0.666	10
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.666	11
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.666	13
UniProt:O00165 HAX1			0.666	14
UniProt:O75955 FLOT1	1	FLOT1 [plasma membrane] (R-HSA-112174)	0.666	4
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.666	7
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.666	8
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.666	17
UniProt:A4D1P6 WDR91	1	WDR91 [cytosol] (R-HSA-9714846)	0.666	16
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.666	18
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.666	16
UniProt:P62158 CALM			0.666	10
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.666	13
UniProt:P09543 CN37			0.666	10
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.666	19
UniProt:Q9H9A5 CNOT10	1	CNOT10 [cytosol] (R-HSA-429878)	0.666	4
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.666	22
UniProt:Q59EV6 Q59EV6			0.666	10
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.666	13
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.666	10
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.666	13
UniProt:Q9Y6M9 NDUFB9	1	NDUFB9 [mitochondrial inner membrane] (R-HSA-60176)	0.666	10
UniProt:Q96D09 GASP2			0.666	5
UniProt:Q6PKC3 TXD11			0.666	7
UniProt:P43243 MATR3			0.666	4
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.666	4
UniProt:P13987 CD59	8	GPI-CD59 [Golgi membrane] (R-HSA-6808772) GPI-CD59 [transport vesicle] (R-HSA-6808775) GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689804) GPI-CD59 [ER to Golgi transport vesicle membrane] (R-HSA-5689801) GPI-CD59 [endoplasmic reticulum membrane] (R-HSA-5689453) CD59 [specific granule membrane] (R-HSA-6799513) CD59 [tertiary granule membrane] (R-HSA-6800885) CD59 [plasma membrane] (R-HSA-2530458)	0.666	10
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.666	4
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.666	13
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.666	4
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.666	13
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.666	4
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.666	7
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.666	10
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.666	10
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.666	4
UniProt:Q15119 PDK2	1	PDK2(?-407) [mitochondrial matrix] (R-HSA-203943)	0.666	10
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.666	14
UniProt:P55345 ANM2			0.659	5
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.612	8
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.602	10
UniProt:Q9BY11 PACSIN1	1	PACSIN1 [cytosol] (R-HSA-8868269)	0.592	3
UniProt:Q8IZQ1 WDFY3			0.584	10
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.573	2
UniProt:Q16650 TBR1			0.556	12
UniProt:Q8WY36-3 Q8WY363			0.556	6
IntAct:EBI-25892128 CCSB			0.556	3
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.556	3
UniProt:Q9BQJ4 TMM47			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	15
UniProt:Q9UNL4 ING4	1	ING4 [nucleoplasm] (R-HSA-3215153)	0.556	3
UniProt:Q3ZCN5 OTOGL	1	OTOGL [extracellular region] (R-HSA-9671863)	0.556	3
UniProt:Q5T7P3 LCE1B	1	LCE1B [cytosol] (R-HSA-6814271)	0.556	15
UniProt:Q96D59 RN183			0.556	3
UniProt:Q86TN1 Q86TN1			0.556	9
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:Q8WWW0-2 RASSF5			0.556	3
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.556	6
UniProt:Q9H0V9 LMAN2L	3	LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689834) LMAN2L [ER to Golgi transport vesicle membrane] (R-HSA-5689832) LMAN2L [endoplasmic reticulum membrane] (R-HSA-5689469)	0.556	3
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	12
UniProt:Q9H7C9 AAMDC			0.556	3
UniProt:Q9NPC3 CIP1			0.556	6
IntAct:EBI-25894571 CCSB			0.556	3
UniProt:P35548 MSX2	1	MSX2 [nucleoplasm] (R-HSA-9007760)	0.556	12
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q8TC29 ENKUR			0.556	6
UniProt:Q9BTA9-5 WAC			0.556	3
UniProt:Q96AM0 Q96AM0			0.556	3
UniProt:Q13113 PDZ1I			0.556	21
UniProt:Q9H171 ZBP1	1	ZBP1 [cytosol] (R-HSA-1591229)	0.556	6
UniProt:Q12765-2 SCRN1			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	9
UniProt:Q7L8T7 Q7L8T7			0.556	6
IntAct:EBI-25866297 CCSB			0.556	15
UniProt:Q9GZL8 BPEC1			0.556	15
UniProt:Q9NPI8 FANCF	2	FANCF [cytosol] (R-HSA-420794) FANCF [nucleoplasm] (R-HSA-419537)	0.556	3
UniProt:P51608 MECP2			0.556	18
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	12
UniProt:Q99871 HAUS7	1	HAUS7 [cytosol] (R-HSA-8855200)	0.556	18
UniProt:Q9GZR2 REXO4			0.556	3
UniProt:Q9BUW7 BBLN			0.556	6
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.556	3
IntAct:EBI-25850770 CCSB			0.556	6
UniProt:Q00266 MAT1A	4	MAT1A H277Afs75 [cytosol] (R-HSA-5603099) MAT1A V348Gfs3 [cytosol] (R-HSA-5603112) MAT1A K181Vfs*5 [cytosol] (R-HSA-5603077) MAT1A [cytosol] (R-HSA-174379)	0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	9
UniProt:P26885 FKBP2			0.556	6
UniProt:A2RU56 A2RU56			0.556	9
UniProt:Q5VWN6 TASO2			0.556	12
UniProt:Q9UHD4 CIDEB			0.556	3
UniProt:P00492 HPRT1	4	HPRT1 [cytosol] (R-HSA-56639) HPRT1 D194N [cytosol] (R-HSA-9734269) HPRT1 G70E [cytosol] (R-HSA-9734286) HPRT1 G140D [cytosol] (R-HSA-9734264)	0.556	15
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	12
UniProt:Q02218 OGDH	1	OGDH [mitochondrial matrix] (R-HSA-69981)	0.556	3
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.556	18
UniProt:P22033 MMUT	10	MUT A378E [mitochondrial matrix] (R-HSA-3323133) MUT G703R [mitochondrial matrix] (R-HSA-3323099) MUT [mitochondrial matrix] (R-HSA-70998) MUT R93H [mitochondrial matrix] (R-HSA-3323138) MUT W105R [mitochondrial matrix] (R-HSA-3323106) MUT G623R [mitochondrial matrix] (R-HSA-3323123) MUT R108C [mitochondrial matrix] (R-HSA-3323139) MUT G215S [mitochondrial matrix] (R-HSA-3323175) MUT N219Y [mitochondrial matrix] (R-HSA-3323146) MUT Q17* [mitochondrial matrix] (R-HSA-3323178)	0.556	12
UniProt:P48444 ARCN1	4	ARCN1 [endoplasmic reticulum membrane] (R-HSA-6810948) ARCN1 [Golgi membrane] (R-HSA-6808714) ARCN1 [transport vesicle] (R-HSA-6808717) ARCN1 [cytosol] (R-HSA-199980)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.556	6
UniProt:Q9UPU5 USP24	1	USP24 [nucleoplasm] (R-HSA-5697004)	0.556	21
UniProt:Q13588 GRAP	1	GRAP [cytosol] (R-HSA-1433547)	0.556	12
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.556	3
UniProt:Q93079 H2BC9	9	Ub-HIST1H2BH [nucleoplasm] (R-HSA-6782558) AcK-HIST1H2BH [nucleoplasm] (R-HSA-4549241) HIST1H2BH [extracellular region] (R-HSA-977580) AcK16-HIST1H2BH [nucleoplasm] (R-HSA-4568682) AcK6-HIST1H2BH [nucleoplasm] (R-HSA-4568718) AcK21-HIST1H2BH [nucleoplasm] (R-HSA-4568657) AcK13-HIST1H2BH [nucleoplasm] (R-HSA-4568705) Ub-121-HIST1H2BH [nucleoplasm] (R-HSA-3364021) HIST1H2BH [nucleoplasm] (R-HSA-181915)	0.556	18
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:O75351 VPS4B	1	VPS4B [cytosol] (R-HSA-917719)	0.556	3
UniProt:Q99614 TTC1			0.556	9
UniProt:O75356 ENTPD5	1	ENTPD5 [extracellular region] (R-HSA-8851371)	0.556	3
UniProt:Q9NY87 SPNXC			0.556	3
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.556	3
UniProt:Q96EY4 TMA16			0.556	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	9
UniProt:Q6UW68 TM205			0.556	3
UniProt:O14662-5 STX16			0.556	15
UniProt:P50749 RASF2			0.556	3
UniProt:Q7Z7K6 CENPV			0.556	15
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q8IWZ3-3 ANKHD1			0.556	3
UniProt:Q8TC84 FANK1			0.556	3
UniProt:Q2QGD7 ZXDC			0.556	3
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.556	6
UniProt:Q9BT81 SOX7	1	SOX7 [nucleoplasm] (R-HSA-5627712)	0.556	15
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [extracellular region] (R-HSA-6806289) CRACR2A [specific granule lumen] (R-HSA-6799553)	0.556	9
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	9
UniProt:P50570-2 DNM2			0.556	6
UniProt:Q3SY56 SP6			0.556	3
UniProt:B7Z3E8 B7Z3E8			0.556	6
UniProt:P29466-3 CASP1			0.556	3
UniProt:Q8N779 Q8N779			0.556	15
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q9BZE4 GTPB4			0.556	3
UniProt:O60749 SNX2	2	SNX2 [Golgi membrane] (R-HSA-434333) SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216)	0.556	6
UniProt:O00203 AP3B1	4	AP3B1 [Golgi membrane] (R-HSA-434335) AP3B1 [cytoplasmic vesicle membrane] (R-HSA-434197) AP3B1(1-859)-BRAF(381-766) fusion [cytosol] (R-HSA-6802269) AP3B1(1-859)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802516)	0.556	6
IntAct:EBI-25872354 ORF			0.556	12
UniProt:Q3SY69 ALDH1L2	1	ALDH1L2 [mitochondrial matrix] (R-HSA-6808493)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	6
UniProt:Q5T7P8-2 SYT6			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	9
UniProt:P52744 ZNF138	1	ZNF138 [nucleoplasm] (R-HSA-974993)	0.556	9
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.556	6
UniProt:P02489 CRYAA			0.556	3
UniProt:Q9NPJ8-3 NXT2			0.556	15
UniProt:P21980-2 P219802			0.556	6
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:O14602 IF1AY			0.556	6
UniProt:Q13303 KCNAB2	3	KCNAB2 [specific granule membrane] (R-HSA-6799627) KCNAB2 [plasma membrane] (R-HSA-1297366) KCNAB2 [tertiary granule membrane] (R-HSA-6800890)	0.556	3
UniProt:Q32MN6 Q32MN6			0.556	9
UniProt:Q6PCB6 ABHD17C	1	ABHD17C [plasma membrane] (R-HSA-9647774)	0.556	21
UniProt:Q9UHX1-2 PUF60			0.556	6
IntAct:EBI-25911596 CCSB			0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496) HSPA1A [cytosol] (R-HSA-6792602)	0.556	9
UniProt:Q6ZTN6-2 ANKRD13D			0.556	9
UniProt:Q96HB5 CC120			0.556	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.556	3
UniProt:Q96HC4 PDLIM5	1	PDLIM5 [cytosol] (R-HSA-6794246)	0.556	9
UniProt:Q86YB0 Q86YB0			0.556	3
UniProt:Q13702-2 Q137022			0.556	18
UniProt:Q15047-2 SETDB1			0.556	15
IntAct:EBI-25836274 CCSB			0.556	12
UniProt:Q92797-2 Q927972			0.556	9
UniProt:Q9UHX1-6 PUF60			0.556	9
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:Q9NS69 TOMM22	1	TOMM22 [mitochondrial outer membrane] (R-HSA-1252180)	0.556	6
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q16799-3 RTN1			0.556	9
UniProt:Q92609 TBCD5			0.556	3
UniProt:P0CI25 TRI49			0.556	9
UniProt:P48730-2 CSNK1D			0.556	15
UniProt:P25398 RPS12	2	RPS12 [nucleoplasm] (R-HSA-6798715) RPS12 [cytosol] (R-HSA-72329)	0.556	3
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.556	6
UniProt:Q71RG4-4 Q71RG44			0.556	6
UniProt:Q6NXT2 H3C			0.556	15
UniProt:Q6NW12 Q6NW12			0.556	9
UniProt:Q9BXP5-4 SRRT			0.556	3
UniProt:Q9BXP5-3 SRRT			0.556	6
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.556	3
UniProt:Q9ULV1 FZD4	3	ub-FZD4 [plasma membrane] (R-HSA-4641182) FZD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138457) FZD4 [plasma membrane] (R-HSA-443956)	0.556	9
UniProt:Q9BVA6 FICD			0.556	3
UniProt:Q16181-2 SEPTIN7			0.556	9
UniProt:P48047 ATP5PO	1	ATP5PO [mitochondrial inner membrane] (R-HSA-164533)	0.556	6
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q9NR11-2 ZNF302			0.556	3
UniProt:Q92615 LAR4B			0.556	3
UniProt:P61009 SPCS3	1	SPCS3 [endoplasmic reticulum membrane] (R-HSA-264916)	0.556	6
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.556	9
UniProt:Q15528-2 MED22			0.556	12
UniProt:P19838-2 NFKB1			0.556	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.556	3
UniProt:O76041 NEBL			0.556	18
UniProt:Q53R41 FAKD1			0.556	9
UniProt:P56545-3 CTBP2			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	6
UniProt:Q9Y4W6 AFG3L2	1	AFG3L2 [mitochondrial inner membrane] (R-HSA-8949650)	0.556	3
UniProt:P51660 Hsd17b4	5	Hsd17b4(1-311) [peroxisomal matrix] (R-MMU-9034354) Hsd17b4(312-735) [peroxisomal matrix] (R-MMU-9034352) Hsd17b4(1-735) [peroxisomal matrix] (R-MMU-9034360) HSD17B4 [cytosol] (R-MMU-9033102) HSD17B4(1-736) [peroxisomal matrix] (R-MMU-192322)	0.556	15
UniProt:Q14005-2 Q140052			0.556	15
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.556	3
UniProt:Q9UNX3 RPL26L1	1	RPL26L1 [cytosol] (R-HSA-72438)	0.556	3
UniProt:Q7Z602 GP141			0.556	3
UniProt:P20719 HXA5			0.556	9
UniProt:Q9BR01-2 Q9BR012			0.556	15
IntAct:EBI-25851697 CCSB			0.556	6
UniProt:Q8NCR9 CLRN3			0.556	9
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.556	3
UniProt:P28676 GCA	2	GCA [extracellular region] (R-HSA-6806174) GCA [azurophil granule lumen] (R-HSA-6799167)	0.556	3
UniProt:Q9H816 DCLRE1B	1	DCLRE1B [nucleoplasm] (R-HSA-6785735)	0.556	9
UniProt:Q9H3H5 DPAGT1	8	DPAGT1 T234Hfs*116 [endoplasmic reticulum membrane] (R-HSA-4549354) DPAGT1 I65N [endoplasmic reticulum membrane] (R-HSA-4549352) DPAGT1 [endoplasmic reticulum membrane] (R-HSA-449262) DPAGT1 V264G [endoplasmic reticulum membrane] (R-HSA-4549333) DPAGT1 Y170C [endoplasmic reticulum membrane] (R-HSA-4549365) DPAGT1 L120M [endoplasmic reticulum membrane] (R-HSA-4549318) DPAGT1 V117I [endoplasmic reticulum membrane] (R-HSA-4549376) DPAGT1 M108I [endoplasmic reticulum membrane] (R-HSA-4549374)	0.556	3
UniProt:P16220 CREB1			0.556	3
UniProt:Q8N988-2 ZNF557			0.556	12
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.556	3
UniProt:Q9Y4X4 KLF12			0.556	3
UniProt:Q9Y2T2 AP3M1	1	AP3M1 [cytosol] (R-HSA-391288)	0.556	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.556	18
UniProt:Q8TCE9 PPL13			0.556	3
IntAct:EBI-25853680 CCSB			0.556	3
UniProt:P04141 CSF2 gene	1	CSF2 [extracellular region] (R-HSA-517562)	0.556	15
UniProt:Q7Z417 NUFP2			0.556	6
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.556	3
UniProt:Q9UQB8-3 BAIAP2			0.556	18
UniProt:O15130-2 O151302			0.556	18
UniProt:Q13939 CALI			0.556	3
UniProt:Q9UQB8-6 BAIAP2			0.556	18
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.556	12
UniProt:Q9UI12 ATP6V1H	2	ATP6V1H [cytosol] (R-HSA-167578) ATP6V1H [plasma membrane] (R-HSA-167602)	0.556	3
UniProt:P62256 UBE2H	2	Ub-C87-UBE2H [cytosol] (R-HSA-8864203) UBE2H [cytosol] (R-HSA-947638)	0.556	3
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.556	3
UniProt:O95455 TGDS			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	18
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.556	3
UniProt:O95073-2 FSBP			0.556	3
UniProt:O15535 ZSC9			0.556	9
UniProt:Q13635-3 PTCH1			0.556	3
UniProt:Q9UJU6 DBNL	7	DBNL [secretory granule lumen] (R-HSA-6801520) DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [cytosol] (R-HSA-202880) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [extracellular region] (R-HSA-6801604)	0.556	3
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.556	3
UniProt:Q9ULW3 ABT1			0.556	9
UniProt:Q8N594 MPND			0.556	3
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.556	6
UniProt:O95447 LCA5L			0.556	18
UniProt:Q96M34 TEX55			0.556	3
UniProt:Q8NEZ2 VPS37A	1	VPS37A [endosome membrane] (R-HSA-184333)	0.556