Reactome | UniProt:Q13485 SMAD4

UniProt:Q13485 SMAD4

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

SMAD4_HUMAN, A8K405

List of interactors in Reactome

Interactors (48)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P84022	2	p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855)	0.984	43
Q15796	1	SMAD2 [cytosol] (R-HSA-3006353)	0.97	31
P12755	1	SKI [nucleoplasm] (R-HSA-173473)	0.942	16
P63279	3	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [cytosol] (R-HSA-4655342) UBE2I [nucleoplasm] (R-HSA-912481)	0.835	6
O43524	11	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.799	12
Q9NPI6	1	DCP1A [cytosol] (R-HSA-430043)	0.779	5
P23769	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.776	10
Q9UPN9	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.748	6
Q9UBE8	1	NLK [cytosol] (R-HSA-4411330)	0.719	6
Q13485	4	SMAD4 [cytosol] (R-HSA-170862) SMAD4 [nucleoplasm] (R-HSA-177103) Ub-SMAD4 [cytosol] (R-HSA-9773859) Ub-SMAD4 [nucleoplasm] (R-HSA-9773863)	0.64	7
P49841	3	GSK3B [cytosol] (R-HSA-2997551) GSK3B [endoplasmic reticulum lumen] (R-HSA-9931408) GSK3B [nucleoplasm] (R-HSA-2022823)	0.636	5
P17676	3	CEBPB [nucleoplasm] (R-HSA-381378) p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343)	0.609	2
Q9Y2T1	1	AXIN2 [cytosol] (R-HSA-3640821)	0.609	4
P70398	1	USP9X [cytosol] (R-MMU-870499)	0.602	4
P21912	1	SDHB [mitochondrial matrix] (R-HSA-9854983)	0.596	5
Q13547	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.596	7
P24468	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.591	4
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.577	6
P05067	12	APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-713) [extracellular region] (R-HSA-879340) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325)	0.556	3
Q15915	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
O15524	1	SOCS1 [cytosol] (R-HSA-204910)	0.553	4
O75925	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.553	2
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.553	6
P16473	1	TSHR [plasma membrane] (R-HSA-391371)	0.553	6
P20823	1	HNF1A [nucleoplasm] (R-HSA-3004629)	0.553	5
P29474	3	2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) NOS3 [cytosol] (R-HSA-202114)	0.553	4
P62324	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.553	4
P78333	1	GPI-GPC5 [plasma membrane] (R-HSA-5362430)	0.553	5
Q16620	2	NTRK2 [plasma membrane] (R-HSA-6798236) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044)	0.553	4
Q6VMQ6	2	ATF7IP [nucleoplasm] (R-HSA-3301918) me3-K16-ATF7IP [nucleoplasm] (R-HSA-9844104)	0.553	2
Q8TE49	1	OTUD7A [cytosol] (R-HSA-8865184)	0.553	4
Q9GZV9	3	FGF23(25-251) [Golgi lumen] (R-HSA-8851630) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624)	0.553	3
Q9NW38	1	FANCL [nucleoplasm] (R-HSA-419520)	0.553	6
Q9NXR7	1	BRE [nucleoplasm] (R-HSA-5682579)	0.553	5
Q9Y6X2	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.553	3
Q04721	5	NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025)	0.539	5
Q12778	5	Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306)	0.536	5
Q13309	1	SKP2 [nucleoplasm] (R-HSA-975554)	0.536	5
P98177	4	Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655)	0.524	2
Q9Y297	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.524	2
P29353	2	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680)	0.519	5
Q00597	1	FANCC [nucleoplasm] (R-HSA-419530)	0.519	5
Q04206	1	p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.519	5
P23458	2	JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [endoplasmic reticulum lumen] (R-HSA-9931304)	0.471	5
P24385	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.471	4
P36896	1	ACVR1B [plasma membrane] (R-HSA-205867)	0.471	4
P52333	1	JAK3 [cytosol] (R-HSA-451893)	0.471	3
Q00534	1	CDK6 [nucleoplasm] (R-HSA-141283)	0.471	3

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