Reactome | PLPP1 [plasma membrane]

PLPP1 [plasma membrane]

Stable Identifier

R-HSA-76106

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PPAP2A, Phosphatidate phosphatase (PPAP2A), LPP1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14494 PLPP1

Gene Names

PLPP1, LPP1, PPAP2A

Chain

chain:1-284

Reference Genes

BioGPS Gene:8611 PLPP1

COSMIC (genes):PLPP1 PLPP1

CTD Gene:8611 PLPP1

dbSNP Gene:8611 PLPP1

ENSEMBL:ENSG00000067113 PLPP1

ENSEMBL_homo_sapiens_GENE:ENSG00000067113.17 PLPP1

HGNC:9228 PLPP1

KEGG Gene (Homo sapiens):8611 PLPP1

Monarch:8611 PLPP1

NCBI Gene:8611 PLPP1

OMIM:607124 PLPP1

UCSC:O14494 PLPP1

Reference Transcript

Other Identifiers

11723665_a_at

11746264_a_at

11754801_x_at

16996234

209147_PM_s_at

209147_s_at

210946_PM_at

210946_at

2857203

2857205

2857206

2857207

2857208

2857209

2857211

2857220

2857228

2857229

2857234

2857235

2857236

2857243

2857255

2857256

2857257

2857258

2857286

34797_at

8112107

81913_at

8611

A_23_P70060

GE54124

GE81316

GO:0000810

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005901

GO:0006629

GO:0006644

GO:0006665

GO:0006670

GO:0006672

GO:0007165

GO:0007205

GO:0008195

GO:0008285

GO:0016020

GO:0016324

GO:0016787

GO:0019216

GO:0023052

GO:0030518

GO:0030521

GO:0042392

GO:0042577

GO:0043226

GO:0045121

GO:0046839

GO:0070062

GO:0106235

HMNXSV003000072

ILMN_1676296

ILMN_1739161

ILMN_2343278

PH_hs_0026469

PH_hs_0034048

TC05001363.hg

g2467297_3p_a_at

Participates

as a member of

PLPP1,2,3 [plasma membrane] (Homo sapiens)

Inferred To

wun [plasma membrane] (Drosophila melanogaster)

LPP1 [plasma membrane] (Saccharomyces cerevisiae)

PLPP1 [plasma membrane] (Bos taurus)

PLPP1 [plasma membrane] (Canis familiaris)

PLPP1 [plasma membrane] (Dictyostelium discoideum)

PLPP1 [plasma membrane] (Gallus gallus)

PLPP1 [plasma membrane] (Sus scrofa)

Plpp1 [plasma membrane] (Mus musculus)

Plpp1 [plasma membrane] (Rattus norvegicus)

DPP1 [plasma membrane] (Saccharomyces cerevisiae)

dpp1 [plasma membrane] (Schizosaccharomyces pombe)

plpp-1.1 [plasma membrane] (Caenorhabditis elegans)

Homologues of PLPP1 [plasma membrane] (Dictyostelium discoideum)

Homologues of PLPP1 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_795714.1, NP_003702.2

Guide to Pharmacology - Targets

1438

OpenTargets

ENSG00000067113

HPA

ENSG00000067113-PLPP1

GeneCards

O14494

Ensembl

ENSG00000067113, ENSP00000264775, ENSP00000302229, ENST00000264775, ENST00000307259

PRO

O14494

Pharos - Targets

O14494

HMDB Protein

HMDBP00237

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:P49768-2 PSEN1			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:P29466-3 CASP1			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3

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