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p-E2F1 [nucleoplasm]
Stable Identifier
R-HSA-187911
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-E2F1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2 Phase (Homo sapiens)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)
CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] (Homo sapiens)
p-E2F1/p-E2F3 [nucleoplasm] (Homo sapiens)
p-E2F1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01094 E2F1
Gene Names
E2F1, RBBP3
Chain
chain:1-437
Reference Genes
BioGPS Gene:1869 E2F1
COSMIC (genes):E2F1 E2F1
CTD Gene:1869 E2F1
dbSNP Gene:1869 E2F1
ENSEMBL:ENSG00000101412 E2F1
HGNC:3113 E2F1
KEGG:hsa:1869 E2F1
Monarch:1869 E2F1
NCBI Gene:1869 E2F1
OMIM:189971 E2F1
UCSC:Q01094 E2F1
Reference Transcript
RefSeq:NM_005225.2 E2F1
Other Identifiers
11723713_at
1322_at
16918445
1869
2028_PM_s_at
2028_s_at
204947_PM_at
204947_at
3903124
3903125
3903126
3903147
3903148
3903149
3903150
3903151
3903153
3903154
3903155
3903157
3903158
3903159
3903161
3903162
3903163
3903164
8065710
A_23_P80032
GE60538
GO:0000077
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005813
GO:0005815
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0008630
GO:0010628
GO:0012501
GO:0030900
GO:0032496
GO:0032991
GO:0035189
GO:0043065
GO:0043226
GO:0043276
GO:0043392
GO:0043565
GO:0045599
GO:0045892
GO:0045893
GO:0045944
GO:0046983
GO:0048146
GO:0048255
GO:0048856
GO:0051726
GO:0060090
GO:0070345
GO:0071466
GO:0072332
GO:0090575
GO:0140110
GO:0140297
GO:1990086
GO:1990837
GO:2000045
HMNXSV003055600
ILMN_2051469
PH_hs_0005226
S49592_s_at
TC20000773.hg
U47677_at
g12669910_3p_s_at
Participates
as a member of
p-E2F1/p-E2F3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
E2F1 [nucleoplasm]
Inferred To
phospho-PXMP4 [nucleoplasm]
(Canis familiaris)
phospho-e2f1 [nucleoplasm]
(Xenopus tropicalis)
phospho-p-E2F1 [nucleoplasm]
(Gallus gallus)
phospho-E2f1 [nucleoplasm]
(Drosophila melanogaster)
phospho-E2f1 [nucleoplasm]
(Mus musculus)
phospho-E2f1 [nucleoplasm]
(Rattus norvegicus)
phospho-E2F1 [nucleoplasm]
(Bos taurus)
phospho-E2F1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_005216.1
OpenTargets
ENSG00000101412
ENSEMBL
ENSP00000345571
,
ENST00000343380
HPA
ENSG00000101412-E2F1
PRO
Q01094
Pharos - Targets
Q01094
PDB
6ULS
,
5M9N
,
1H24
,
2AZE
,
6G0P
,
1O9K
,
5M9O
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.97
30
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.95
17
UniProt:P03129 VE7
0.77
6
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.725
6
UniProt:Q92547 TOPBP1
1
TOPBP1 [nucleoplasm]
(R-HSA-5684878)
0.704
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.656
3
UniProt:Q92830 KAT2A
1
KAT2A [nucleoplasm]
(R-HSA-3006516)
0.65
3
UniProt:Q14684 RRP1B
0.649
10
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.646
8
UniProt:Q8NEM0 MCPH1
1
MCPH1 [nucleoplasm]
(R-HSA-2429638)
0.633
6
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.615
3
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.609
3
UniProt:Q14201 BTG3
0.602
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.589
2
UniProt:Q96JM7 LMBL3
0.589
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.564
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.544
2
IntAct:EBI-2549087 CASP7
0.527
2
IntAct:EBI-5279495 E2F1
0.527
2
IntAct:EBI-2549104 CCNA2
0.527
3
IntAct:EBI-2549096 TP73
0.527
3
IntAct:EBI-20620429 DIABLO
0.524
2
UniProt:Q96IZ0 PAWR
0.524
2
UniProt:Q9Y618 NCOR2
2
NCOR2 [nucleoplasm]
(R-HSA-442469)
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
0.524
2
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.524
2
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
3
UniProt:Q9UPP1 PHF8
1
PHF8 [nucleoplasm]
(R-HSA-5423096)
0.499
2
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.462
2
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