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CASP8(217-374) [cytosol]
Stable Identifier
R-HSA-75975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CASP8, p18 subunit of Caspase 8
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
Viral serpin blocks caspase-8 activity (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8:viral CRMA/SPI-2 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
RIPK1 variant is not cleaved by CASP8 (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
ASC binds Caspase-8 complex (Homo sapiens)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
MALT1:active caspase-8 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
MALT1:active caspase-8 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Caspase-8 binds MALT (Homo sapiens)
MALT1:active caspase-8 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Caspase-8 cleaves IL1B precursor (Homo sapiens)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
MALT1:active caspase-8 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
Processing of caspases (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)
Caspase-8 processing within TLR3 complex (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Caspase-mediated cleavage of plectin-1 (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation, myristolyation of BID and translocation to mitochondria (Homo sapiens)
Caspase-8 activates BID by cleavage (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
RIPK3 is cleaved by CASP8 (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
TRAF1 is cleaved by caspases (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
Viral serpin blocks caspase-8 activity (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
active caspase-8:viral CRMA/SPI-2 [cytosol] (Homo sapiens)
active caspase-8 [cytosol] (Homo sapiens)
Caspase-8 dimer [cytosol] (Homo sapiens)
CASP8(217-374) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14790 CASP8
Gene Names
CASP8, MCH5
Chain
propeptide:1-216, chain:217-374, propeptide:375-384, chain:385-479
Reference Genes
BioGPS Gene:841 CASP8
COSMIC (genes):CASP8 CASP8
CTD Gene:841 CASP8
dbSNP Gene:841 CASP8
ENSEMBL:ENSG00000064012 CASP8
ENSEMBL_homo_sapiens_GENE:ENSG00000064012.24 CASP8
HGNC:1509 CASP8
KEGG Gene (Homo sapiens):841 CASP8
Monarch:841 CASP8
NCBI Gene:841 CASP8
OMIM:601763 CASP8
UCSC:Q14790 CASP8
Reference Transcript
RefSeq:XM_005246890.3 CASP8
RefSeq:NM_033356.3 CASP8
RefSeq:XM_005246891.4 CASP8
RefSeq:NM_033358.3 CASP8
RefSeq:XM_005246892.1 CASP8
RefSeq:NM_001080124.1 CASP8
RefSeq:XM_005246886.1 CASP8
RefSeq:XM_006712789.1 CASP8
RefSeq:XM_005246887.1 CASP8
RefSeq:NM_001080125.1 CASP8
RefSeq:XM_006712790.3 CASP8
RefSeq:XM_005246888.1 CASP8
RefSeq:NM_001228.4 CASP8
RefSeq:XM_006712793.2 CASP8
RefSeq:XM_005246889.1 CASP8
RefSeq:NM_033355.3 CASP8
Other Identifiers
11728978_x_at
11741554_x_at
11742324_a_at
11749790_a_at
11754153_x_at
11756062_x_at
1553306_at
207686_PM_s_at
207686_s_at
213373_PM_s_at
213373_s_at
2522729
2522730
2522731
2522732
2522733
2522743
2522744
2522745
2522746
2522747
2522750
2522751
2522752
2522753
2522755
2522756
2522758
2522759
2522764
2522766
2522768
2522769
2522770
2522771
3104672
31491_s_at
33774_at
33775_s_at
8047419
841
A_14_P116206
A_14_P138041
A_23_P209389
A_24_P148499
A_24_P157087
GE60202
GO:0001525
GO:0001817
GO:0002376
GO:0003824
GO:0004197
GO:0005123
GO:0005164
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0005886
GO:0006508
GO:0006915
GO:0007507
GO:0008233
GO:0008234
GO:0008625
GO:0010803
GO:0012501
GO:0016485
GO:0016787
GO:0022414
GO:0023052
GO:0030027
GO:0030101
GO:0030154
GO:0030163
GO:0030225
GO:0030335
GO:0031264
GO:0031265
GO:0031625
GO:0032025
GO:0032355
GO:0032496
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042110
GO:0042113
GO:0042802
GO:0042981
GO:0043065
GO:0043123
GO:0043124
GO:0043226
GO:0043525
GO:0044297
GO:0044877
GO:0045088
GO:0045471
GO:0045651
GO:0045862
GO:0048856
GO:0048870
GO:0051603
GO:0051604
GO:0051716
GO:0060546
GO:0060715
GO:0070269
GO:0071260
GO:0071407
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097202
GO:0097264
GO:0097342
GO:0098542
GO:0140096
HMNXSV003024001
HMNXSV003029851
Hs.19949.2.S2_3p_a_at
Hs2.381231.5.S1_3p_at
ILMN_1673757
ILMN_1787749
ILMN_1809313
ILMN_2377733
PH_hs_0023198
TC02003767.hg
X98172_at
X98176_at
X98178_s_at
g4502582_3p_a_at
Participates
as a component of
Caspase-8 dimer [cytosol] (Homo sapiens)
as an output of
Processing of caspases (Homo sapiens)
Other forms of this molecule
CASP8(1-374) [cytosol]
CASP8(217-374) [mitochondrial outer membrane]
CASP8(385-479) [mitochondrial outer membrane]
CASP8(385-479) [cytosol]
CASP8(375-384) [cytosol]
CASP8(1-216) [cytosol]
CASP8(1-479) [cytosol]
Inferred To
CASP8(217-374) [cytosol]
(Gallus gallus)
CASP8 [cytosol]
(Bos taurus)
CASP8 [cytosol]
(Canis familiaris)
CASP8 [cytosol]
(Sus scrofa)
Casp8 [cytosol]
(Mus musculus)
Casp8 [cytosol]
(Rattus norvegicus)
casp10 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001073593.1
,
XP_006712856.1
,
NP_203519.1
,
XP_006712853.1
,
XP_005246943.1
,
XP_006712852.1
,
XP_005246949.1
,
NP_001219.2
,
NP_001073594.1
,
XP_005246946.1
,
XP_005246947.1
,
XP_005246944.1
,
XP_005246948.1
,
NP_203520.1
,
NP_203522.1
,
XP_005246945.1
Guide to Pharmacology - Targets
1624
OpenTargets
ENSG00000064012
ZINC - Substances
CASP8_HUMAN
ZINC target
Q14790
PRO
Q14790
PDB
1QTN
,
2Y1L
,
7LVJ
,
5JQE
,
4ZBW
,
2FUN
,
3H11
,
5H33
,
6PX9
,
4PS1
,
2C2Z
,
3KJN
,
5H31
,
1I4E
,
7DEE
,
4PRZ
,
5L08
,
6AGW
,
3KJQ
,
4JJ7
,
1F9E
,
2K7Z
,
7LVM
,
1QDU
ZINC - Investigational
CASP8_HUMAN
GeneCards
Q14790
HPA
ENSG00000064012-CASP8
Ensembl
ENSP00000388306
,
ENST00000440732
,
ENSP00000512370
,
ENST00000413726
,
ENST00000447616
,
ENST00000392263
,
ENSP00000512382
,
ENSP00000351273
,
ENST00000432109
,
ENST00000696087
,
ENSG00000064012
,
ENSP00000397528
,
ENST00000444430
,
ENST00000673742
,
ENSP00000264275
,
ENSP00000412523
,
ENST00000358485
,
ENSP00000501268
,
ENSP00000394434
,
ENSP00000512369
,
ENST00000323492
,
ENSP00000325722
,
ENST00000264275
,
ENSP00000376087
,
ENSP00000396869
,
ENST00000392258
,
ENST00000696068
,
ENST00000696067
,
ENSP00000376091
Pharos - Targets
Q14790
ZINC - Predictions - Purchasable
CASP8_HUMAN
Orphanet
16839
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.98
47
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.959
30
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.92
16
UniProt:P50591 TNFSF10
1
TNFSF10 [extracellular region]
(R-HSA-66186)
0.919
20
UniProt:O00220 TNFRSF10A
1
TNFRSF10A [plasma membrane]
(R-HSA-5633393)
0.817
11
UniProt:O14763 TNFRSF10B
1
TNFRSF10B [plasma membrane]
(R-HSA-65505)
0.749
7
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.744
5
UniProt:O15519 CFLAR
1
CFLAR(1-376) [cytosol]
(R-HSA-51925)
0.744
10
UniProt:Q92851 CASP10
4
CASP10(220-415) [cytosol]
(R-HSA-933458)
CASP10(1-219) [cytosol]
(R-HSA-933454)
CASP10(416-521) [cytosol]
(R-HSA-933455)
CASP10(1-521) [cytosol]
(R-HSA-933453)
0.734
6
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.725
6
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.704
4
UniProt:Q9UKL3 CASP8AP2
2
monoSUMO1-K1813-CASP8AP2 [nucleoplasm]
(R-HSA-3927850)
CASP8AP2 [nucleoplasm]
(R-HSA-3927945)
0.704
5
UniProt:P25445-1 FAS
0.669
3
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.602
6
UniProt:P51572 BCAP31
6
BCAP31 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985503)
BCAP31 [endoplasmic reticulum membrane]
(R-HSA-9714333)
BCAP31(2-245) [endoplasmic reticulum membrane]
(R-HSA-201587)
BCAP31(165-237) [endoplasmic reticulum membrane]
(R-HSA-351909)
BCAP31(2-164) [endoplasmic reticulum membrane]
(R-HSA-351826)
BCAP31(238-246) [cytosol]
(R-HSA-351912)
0.589
3
UniProt:O15519-1 CFLAR
5
M1polyUb-K351,K353-CFLAR(1-480) [cytosol]
(R-HSA-9794015)
CFLAR(377-480) [cytosol]
(R-HSA-3465483)
K63polyUb-CFLAR(1-480) [cytosol]
(R-HSA-9818805)
CFLAR(1-376) [cytosol]
(R-HSA-3465408)
CFLAR(1-480) [cytosol]
(R-HSA-3371356)
0.564
2
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
0.564
2
UniProt:Q96AX1 VPS33A
1
VPS33A [endosome membrane]
(R-HSA-2197804)
0.556
3
UniProt:P13051-2 UNG
0.556
3
UniProt:Q06787-7 FMR1
0.556
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.556
3
UniProt:Q9BY76 ANGPTL4
3
ANGPTL4 [extracellular region]
(R-HSA-381271)
ANGPTL4 [extracellular region]
(R-HSA-6784897)
ANGPTL4(164-406) [extracellular region]
(R-HSA-9762251)
0.547
2
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
2
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.527
3
UniProt:O60936 NOL3
0.524
3
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.524
3
UniProt:Q969K3 RNF34
2
RNF34 [nucleoplasm]
(R-HSA-6804442)
RNF34 [cytosol]
(R-HSA-975998)
0.508
3
UniProt:Q9Y3D6 FIS1
2
FIS1 [peroxisomal membrane]
(R-HSA-9033123)
FIS1 [cytosol]
(R-HSA-9033099)
0.499
2
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.499
3
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.499
10
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