Reactome | MPHOSPH6 [nucleoplasm]

MPHOSPH6 [nucleoplasm]

Stable Identifier

R-HSA-6791553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

M-phase phosphoprotein 6, MPH6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99547 MPHOSPH6

Gene Names

MPHOSPH6, MPP6

Chain

chain:1-160

Reference Genes

BioGPS Gene:10200 MPHOSPH6

COSMIC (genes):MPHOSPH6 MPHOSPH6

COSMIC (genes):MPP6 MPHOSPH6

CTD Gene:10200 MPHOSPH6

dbSNP Gene:10200 MPHOSPH6

ENSEMBL:ENSG00000135698 MPHOSPH6

HGNC:7214 MPHOSPH6

KEGG:hsa:10200 MPHOSPH6

Monarch:10200 MPHOSPH6

NCBI Gene:10200 MPHOSPH6

OMIM:605500 MPHOSPH6

UCSC:Q99547 MPHOSPH6

Reference Transcript

RefSeq:NM_005792.2 MPHOSPH6

Other Identifiers

10200

11743466_at

11761580_at

11761581_x_at

1554906_PM_a_at

1554906_a_at

16828705

203740_PM_at

203740_at

31864_at

3701839

3701840

3701841

3701843

3701845

3701846

3701852

3701853

3701854

3701855

3701857

3701858

3701859

8003068

A_23_P140848

A_24_P926529

GE60204

GO:0000176

GO:0000178

GO:0000460

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0043226

HMNXSV003029341

Hs2.331968.1.S1_3p_s_at

ILMN_1781360

PH_hs_0023895

PH_hs_0037364

TC16001302.hg

X98263_at

g5031918_3p_at

Participates

as a component of

EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)

Other forms of this molecule

MPHOSPH6 [nucleolus]

Inferred To

mpp6 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of MPHOSPH6 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of MPHOSPH6 [nucleoplasm] (Saccharomyces cerevisiae)

Mphosph6 [nucleoplasm] (Mus musculus)

Mphosph6 [nucleoplasm] (Rattus norvegicus)

MPHOSPH6 [nucleoplasm] (Bos taurus)

MPHOSPH6 [nucleoplasm] (Caenorhabditis elegans)

MPHOSPH6 [nucleoplasm] (Canis familiaris)

MPHOSPH6 [nucleoplasm] (Dictyostelium discoideum)

MPHOSPH6 [nucleoplasm] (Gallus gallus)

MPHOSPH6 [nucleoplasm] (Sus scrofa)

Mpp6 [nucleoplasm] (Drosophila melanogaster)

mphosph6 [nucleoplasm] (Danio rerio)

mphosph6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005783.2

ENSEMBL

ENSP00000258169, ENST00000258169, ENSG00000135698

OpenTargets

ENSG00000135698

GeneCards

MPHOSPH6

HPA

ENSG00000135698-MPHOSPH6

PRO

Q99547

Pharos - Targets

Q99547

GlyGen

Q99547

PDB

6H25, 6D6Q, 6D6R

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01780 EXOSC10	2	EXOSC10 [nucleoplasm] (R-HSA-6791547) EXOSC10 [nucleolus] (R-HSA-9935809)	0.807	7
UniProt:Q9NQT5 EXOSC3	3	EXOSC3 [cytosol] (R-HSA-430017) EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [nucleolus] (R-HSA-9935842)	0.788	7
UniProt:Q13868 EXOSC2	3	EXOSC2 [cytosol] (R-HSA-429999) EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [nucleolus] (R-HSA-9935794)	0.773	7
UniProt:Q13901 C1D	2	C1D [nucleoplasm] (R-HSA-6791515) C1D [nucleolus] (R-HSA-9935822)	0.744	6
UniProt:Q9NPD3 EXOSC4	3	EXOSC4 [nucleolus] (R-HSA-9935803) EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.725	6
UniProt:Q9NQT4 EXOSC5	3	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [nucleolus] (R-HSA-9935829)	0.706	6
UniProt:P42285 SKIV2L2	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.693	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8N3Z6 ZCCHC7	1	ZCCHC7 [nucleolus] (R-HSA-9930045)	0.527	2
UniProt:Q9Y3B2 EXOSC1	3	EXOSC1 [cytosol] (R-HSA-429841) EXOSC1 [nucleoplasm] (R-HSA-6791578) EXOSC1 [nucleolus] (R-HSA-9935836)	0.527	5
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	3
UniProt:Q8TF46 DI3L1			0.527	4
UniProt:Q12788 TBL3	1	TBL3 [nucleoplasm] (R-HSA-6790620)	0.527	2
UniProt:Q96B26 EXOSC8	3	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [nucleolus] (R-HSA-9935805)	0.527	4
UniProt:Q9UNX4 WDR3	1	WDR3 [nucleoplasm] (R-HSA-6790724)	0.527	2
UniProt:Q8NDF8 TENT4B	1	TENT4B [nucleolus] (R-HSA-9935834)	0.527	2
UniProt:Q15024 EXOSC7	3	EXOSC7 [nucleolus] (R-HSA-9935779) EXOSC7 [nucleoplasm] (R-HSA-6791543) EXOSC7 [cytosol] (R-HSA-430030)	0.527	4

Cite Us!