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MPHOSPH6 [nucleoplasm]
Stable Identifier
R-HSA-6791553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
M-phase phosphoprotein 6, MPH6_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nuclear RNA decay (Homo sapiens)
MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99547 MPHOSPH6
Gene Names
MPHOSPH6, MPP6
Chain
chain:1-160
Reference Genes
BioGPS Gene:10200 MPHOSPH6
COSMIC (genes):MPHOSPH6 MPHOSPH6
COSMIC (genes):MPP6 MPHOSPH6
CTD Gene:10200 MPHOSPH6
dbSNP Gene:10200 MPHOSPH6
ENSEMBL:ENSG00000135698 MPHOSPH6
HGNC:7214 MPHOSPH6
KEGG:hsa:10200 MPHOSPH6
Monarch:10200 MPHOSPH6
NCBI Gene:10200 MPHOSPH6
OMIM:605500 MPHOSPH6
UCSC:Q99547 MPHOSPH6
Reference Transcript
RefSeq:NM_005792.2 MPHOSPH6
Other Identifiers
10200
11743466_at
11761580_at
11761581_x_at
1554906_PM_a_at
1554906_a_at
16828705
203740_PM_at
203740_at
31864_at
3701839
3701840
3701841
3701843
3701845
3701846
3701852
3701853
3701854
3701855
3701857
3701858
3701859
8003068
A_23_P140848
A_24_P926529
GE60204
GO:0000176
GO:0000178
GO:0000460
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0043226
HMNXSV003029341
Hs2.331968.1.S1_3p_s_at
ILMN_1781360
PH_hs_0023895
PH_hs_0037364
TC16001302.hg
X98263_at
g5031918_3p_at
Participates
as a component of
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(Homo sapiens)
Other forms of this molecule
MPHOSPH6 [nucleolus]
Inferred To
mpp6 [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of MPHOSPH6 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of MPHOSPH6 [nucleoplasm]
(Saccharomyces cerevisiae)
Mphosph6 [nucleoplasm]
(Mus musculus)
Mphosph6 [nucleoplasm]
(Rattus norvegicus)
MPHOSPH6 [nucleoplasm]
(Bos taurus)
MPHOSPH6 [nucleoplasm]
(Caenorhabditis elegans)
MPHOSPH6 [nucleoplasm]
(Canis familiaris)
MPHOSPH6 [nucleoplasm]
(Dictyostelium discoideum)
MPHOSPH6 [nucleoplasm]
(Gallus gallus)
MPHOSPH6 [nucleoplasm]
(Sus scrofa)
Mpp6 [nucleoplasm]
(Drosophila melanogaster)
mphosph6 [nucleoplasm]
(Danio rerio)
mphosph6 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005783.2
ENSEMBL
ENSP00000258169
,
ENST00000258169
,
ENSG00000135698
OpenTargets
ENSG00000135698
GeneCards
MPHOSPH6
HPA
ENSG00000135698-MPHOSPH6
PRO
Q99547
Pharos - Targets
Q99547
GlyGen
Q99547
PDB
6H25
,
6D6Q
,
6D6R
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01780 EXOSC10
2
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
EXOSC10 [nucleolus]
(R-HSA-9935809)
0.807
7
UniProt:Q9NQT5 EXOSC3
3
EXOSC3 [cytosol]
(R-HSA-430017)
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [nucleolus]
(R-HSA-9935842)
0.788
7
UniProt:Q13868 EXOSC2
3
EXOSC2 [cytosol]
(R-HSA-429999)
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [nucleolus]
(R-HSA-9935794)
0.773
7
UniProt:Q13901 C1D
2
C1D [nucleoplasm]
(R-HSA-6791515)
C1D [nucleolus]
(R-HSA-9935822)
0.744
6
UniProt:Q9NPD3 EXOSC4
3
EXOSC4 [nucleolus]
(R-HSA-9935803)
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.725
6
UniProt:Q9NQT4 EXOSC5
3
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
EXOSC5 [nucleolus]
(R-HSA-9935829)
0.706
6
UniProt:P42285 SKIV2L2
2
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
MTREX [nucleolus]
(R-HSA-9935826)
0.693
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q8N3Z6 ZCCHC7
1
ZCCHC7 [nucleolus]
(R-HSA-9930045)
0.527
2
UniProt:Q9Y3B2 EXOSC1
3
EXOSC1 [cytosol]
(R-HSA-429841)
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
EXOSC1 [nucleolus]
(R-HSA-9935836)
0.527
5
UniProt:O60293 ZFC3H1
1
ZFC3H1 [nucleoplasm]
(R-HSA-9930046)
0.527
3
UniProt:Q8TF46 DI3L1
0.527
4
UniProt:Q12788 TBL3
1
TBL3 [nucleoplasm]
(R-HSA-6790620)
0.527
2
UniProt:Q96B26 EXOSC8
3
EXOSC8 [cytosol]
(R-HSA-429912)
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [nucleolus]
(R-HSA-9935805)
0.527
4
UniProt:Q9UNX4 WDR3
1
WDR3 [nucleoplasm]
(R-HSA-6790724)
0.527
2
UniProt:Q8NDF8 TENT4B
1
TENT4B [nucleolus]
(R-HSA-9935834)
0.527
2
UniProt:Q15024 EXOSC7
3
EXOSC7 [nucleolus]
(R-HSA-9935779)
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
EXOSC7 [cytosol]
(R-HSA-430030)
0.527
4
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