Reactome | PLAU(21-431) [plasma membrane]

PLAU(21-431) [plasma membrane]

Stable Identifier

R-HSA-158945

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PLAU, urokinase plasminogen activator (one-chain), uPA

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P00749 PLAU

Gene Names

PLAU

Chain

signal peptide:1-20, chain:21-431, chain:21-177, chain:156-177, chain:179-431

Reference Genes

BioGPS Gene:5328 PLAU

COSMIC (genes):PLAU PLAU

CTD Gene:5328 PLAU

dbSNP Gene:5328 PLAU

ENSEMBL:ENSG00000122861 PLAU

ENSEMBL_homo_sapiens_GENE:ENSG00000122861.16 PLAU

HGNC:9052 PLAU

KEGG Gene (Homo sapiens):5328 PLAU

Monarch:5328 PLAU

NCBI Gene:5328 PLAU

OMIM:191840 PLAU

UCSC:P00749 PLAU

Reference Transcript

Other Identifiers

11717154_a_at

11717886_a_at

11754119_a_at

16706180

205479_PM_s_at

205479_s_at

211668_PM_s_at

211668_s_at

3252040

3252042

3252043

3252044

3252045

3252047

3252049

3252050

3252051

3252052

3252053

3252054

3252056

3252058

3252061

3252062

3252063

3252064

37310_at

5328

7928429

A_23_P24104

A_33_P3306146

GE59641

GO:0001666

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0006508

GO:0006935

GO:0007155

GO:0007165

GO:0007596

GO:0007599

GO:0008233

GO:0008236

GO:0009897

GO:0009986

GO:0010469

GO:0010755

GO:0010757

GO:0014909

GO:0014910

GO:0016787

GO:0023052

GO:0030155

GO:0030335

GO:0031410

GO:0031639

GO:0033628

GO:0035579

GO:0038195

GO:0042060

GO:0042127

GO:0042730

GO:0043226

GO:0048870

GO:0051604

GO:0051917

GO:0051918

GO:0061041

GO:0070062

GO:0070821

GO:0097180

GO:0098637

GO:0140096

GO:1905370

GO:2000097

HMNXSV003015345

ILMN_1656057

PH_hs_0031336

TC10000475.hg

X02419_rna1_s_at

g340155_3p_s_at

g4505862_3p_a_at

Participates

as a component of

PLAU(21-431):PI-PLAUR [plasma membrane] (Homo sapiens)

as a member of

Other forms of this molecule

PLAU(21-177) [plasma membrane]

PLAU(179-431) [plasma membrane]

PLAU(21-431) [extracellular region]

PLAU(21-431) [specific granule membrane]

PLAU(21-431) [tertiary granule membrane]

Inferred To

Plau [plasma membrane] (Mus musculus)

Plau [plasma membrane] (Rattus norvegicus)

PLAU [plasma membrane] (Bos taurus)

PLAU [plasma membrane] (Canis familiaris)

PLAU [plasma membrane] (Sus scrofa)

plaub [plasma membrane] (Danio rerio)

PLAU(21-431) [plasma membrane] (Gallus gallus)

Cross References

RefSeq

XP_011538168.1, NP_001306120.1, NP_002649.1, NP_001138503.1

ZINC - World Drugs

UROK_HUMAN

Guide to Pharmacology - Targets

2393

OpenTargets

ENSG00000122861

ZINC - FDA approved

UROK_HUMAN

ZINC - Substances

UROK_HUMAN

ZINC target

P00749

PRO

P00749

PDB

3MHW, 4XSK, 2VIN, 1OWD, 5ZC5, 7ZRT, 6JYP, 4FU7, 5ZA8, 4OS1, 2I9A, 4MNW, 6AG9, 2VIW, 1SQT, 4FUH, 1KDU, 1C5Y, 1W14, 3BT1, 4X1N, 6NMB, 1GJ7, 1FV9, 1SQA, 5ZAE, 1F5L, 1W0Z, 5YC7, 6JYQ, 4FUF, 5Z1C, 1OWK, 3OY6, 4K24, 1EJN, 1F92, 6XVD, 5ZAJ, 4OS5, 4OS7, 5ZA7, 1OWJ, 1URK, 1O5A, 6L04, 7ZRR, 4ZKN, 4X1P, 3MWI, 1GI8, 2O8W, 4X0W, 2NWN, 4ZKS, 1VJA, 4DW2, 1OWH, 1C5X, 2VIQ, 4FU9, 1W11, 3KGP, 3M61, 6AG7, 1LMW, 4JK5, 4X1R, 4ZHM, 6AG2, 5ZAH, 1O5C, 6AG3, 2O8T, 1GJD, 5YC6, 4OS2, 1SQO, 5ZAG, 4MNV, 4X1Q, 4DVA, 1O3P, 1GJ9, 1GI9, 4H42, 2FD6, 5WXR, 2VIO, 1C5Z, 4OS6, 5HGG, 1VJ9, 1W13, 1SC8, 4FU8, 1GJB, 5ZAF, 7VM7, 7VM6, 4FUE, 4FUI, 3OY5, 5WXT, 7VM5, 4OS4, 3KID, 3BT2, 3QN7, 4FUJ, 2VNT, 4MNY, 3U73, 1OWE, 3IG6, 1O5B, 1W12, 3OX7, 4ZHL, 4FUC, 4FUG, 2VIV, 5WXQ, 5XG4, 1GJC, 2O8U, 4GLY, 1GJ8, 5WXO, 4FUD, 1OWI, 3KHV, 5WXP, 4ZKO, 1U6Q, 1W10, 4X1S, 2I9B, 2VIP, 4MNX, 1GI7, 2R2W, 7DZD, 1GJA, 4ZKR, 7VM4, 5ZA9, 4FUB, 6L05, 3PB1, 1F5K, 4JK6, 1C5W, 5WXF, 5WXS

ZINC - Investigational

UROK_HUMAN

HPA

ENSG00000122861-PLAU

GeneCards

P00749

Ensembl

ENSP00000361850, ENSG00000122861, ENSP00000388474, ENST00000372764, ENST00000446342

Pharos - Targets

P00749

Orphanet

18967

ZINC - Predictions - Purchasable

UROK_HUMAN

HMDB Protein

HMDBP02055

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55000 SLUR1			0.59	2
UniProt:P05121 SERPINE1	3	SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [extracellular region] (R-HSA-158797)	0.59	2
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.564	3
UniProt:Q03405-1 PLAUR			0.558	2
UniProt:Q9UKQ2 ADA28			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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