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NGF(19-241) [extracellular region]
Stable Identifier
R-HSA-187033
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
beta-NGF pro-precursor, Nerve Growth Factor pro-precursor, Neurotrophin pro-precursor
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
NFG and proNGF binds to p75NTR (Homo sapiens)
Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)
pro-beta NGF:p75NTR:sortilin [plasma membrane] (Homo sapiens)
pro-beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF(19-241) [extracellular region] (Homo sapiens)
pro-beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF(19-241) [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)
pro-beta-NGF homodimer [extracellular region] (Homo sapiens)
NGF(19-241) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01138 NGF
Gene Names
NGF, NGFB
Chain
signal peptide:1-18, propeptide:19-121, chain:122-241
Reference Genes
BioGPS Gene:4803 NGF
COSMIC (genes):NGF NGF
CTD Gene:4803 NGF
dbSNP Gene:4803 NGF
ENSEMBL:ENSG00000134259 NGF
HGNC:7808 NGF
KEGG:hsa:4803 NGF
Monarch:4803 NGF
NCBI Gene:4803 NGF
OMIM:162030 NGF
UCSC:P01138 NGF
Reference Transcript
RefSeq:NM_002506.3 NGF
RefSeq:XM_006710663.4 NGF
RefSeq:XM_054336790.1 NGF
Participates
as a component of
pro-beta-NGF homodimer [extracellular region] (Homo sapiens)
Other forms of this molecule
NGF [extracellular region]
NGF(19-241) [endoplasmic reticulum lumen]
NGF(19-241) [Golgi lumen]
NGF(1-241) [endoplasmic reticulum lumen]
NGF [cytosol]
NGF [Golgi lumen]
Inferred To
Ngf [extracellular region]
(Mus musculus)
NGF [extracellular region]
(Bos taurus)
NGF [extracellular region]
(Canis familiaris)
NGF [extracellular region]
(Sus scrofa)
NGF(19-241) [extracellular region]
(Gallus gallus)
ngf [extracellular region]
(Danio rerio)
ngf [extracellular region]
(Xenopus tropicalis)
pro-beta-NGF precursor [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
XP_054192765.1
,
NP_002497.2
,
XP_006710726.1
OpenTargets
ENSG00000134259
ENSEMBL
ENSP00000506492
,
ENSP00000506569
,
ENSG00000134259
,
ENSP00000358525
,
ENSP00000505558
,
ENSP00000502831
,
ENST00000680116
,
ENST00000369512
,
ENST00000676038
,
ENST00000680752
,
ENST00000680540
,
ENSP00000502380
,
ENSP00000505694
,
ENST00000679806
,
ENST00000675637
ZINC - Substances
NGF_HUMAN
ZINC target
P01138
PRO
P01138
GlyGen
P01138
PDB
2IFG
,
4EDW
,
6YW8
,
1SG1
,
4EDX
,
5JZ7
,
4ZBN
,
1WWW
HPA
ENSG00000134259-NGF
GeneCards
NGF
Pharos - Targets
P01138
Orphanet
NGF
HMDB Protein
HMDBP02581
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07174 Ngfr
8
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194476)
Ngfr [extracellular region]
(R-RNO-194470)
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [plasma membrane]
(R-RNO-193664)
0.722
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
NTRK1 [plasma membrane]
(R-HSA-3008784)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
0.683
3
UniProt:Q99523 SORT1
2
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
SORT1 [Golgi membrane]
(R-HSA-434332)
0.676
5
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
9
UniProt:P20042 EIF2S2
1
EIF2S2 [cytosol]
(R-HSA-72512)
0.556
3
UniProt:P08138 NGFR
7
NGFR(273-427) [nucleoplasm]
(R-HSA-197473)
NGFR(251-272) [plasma membrane]
(R-HSA-194509)
NGFR(273-427) [cytosol]
(R-HSA-194458)
NGFR(251-427) [endosome]
(R-HSA-209541)
NGFR(251-427) [plasma membrane]
(R-HSA-194476)
NGFR(29-250) [extracellular region]
(R-HSA-194470)
NGFR [plasma membrane]
(R-HSA-193664)
0.544
2
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