Reactome | MAP2K2(1-10) [cytosol]

MAP2K2(1-10) [cytosol]

Stable Identifier

R-HSA-5211334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP2K2 small LF fragment

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Literature References

PubMed ID	Title	Journal	Year
9703991	Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages Vitale, G, Pellizzari, R, Recchi, C, Napolitani, G, Mock, M, Montecucco, C	Biochem. Biophys. Res. Commun.	1998
9563949	Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor Duesbery, NS, Webb, CP, Leppla, SH, Gordon, VM, Klimpel, KR, Copeland, TD, Ahn, NG, Oskarsson, MK, Fukasawa, K, Paull, KD, Vande Woude, GF	Science	1998

External Reference Information

External Reference

UniProt:P36507 MAP2K2

Gene Names

MAP2K2, MEK2, MKK2, PRKMK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:5605 MAP2K2

COSMIC (genes):MAP2K2 MAP2K2

CTD Gene:5605 MAP2K2

dbSNP Gene:5605 MAP2K2

ENSEMBL:ENSG00000126934 MAP2K2

HGNC:6842 MAP2K2

KEGG Gene (Homo sapiens):5605 MAP2K2

Monarch:5605 MAP2K2

NCBI Gene:5605 MAP2K2

OMIM:601263 MAP2K2

UCSC:P36507 MAP2K2

Reference Transcript

RefSeq:NM_030662.3 MAP2K2

Other Identifiers

0003710047

1131_at

11716318_x_at

1S9I

202424_at

213490_s_at

3023305

3023308

3023309

3023310

3835

3846639

3846640

3846643

3846645

3846646

3846650

3846652

3846653

3846654

3846659

3846660

3846663

3846664

3846665

3846666

4H3Q

51993

5605

8032761

A_23_P208835

AAH00471

AAH18645

BC000471

BC018645

CAB003835

CCDS12120

ENSG00000126934

ENSP00000262948

ENST00000262948

ENST00000262948.9

EntrezGene:5605

EntrezGene:MAP2K2

g13489053_3p_at

g13489053_3p_x_at

G5E9C7

GE57609

GO:0000165

GO:0000166

GO:0000187

GO:0000278

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005078

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005777

GO:0005778

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005911

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007346

GO:0008150

GO:0009058

GO:0009898

GO:0010629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0023014

GO:0030165

GO:0030234

GO:0030674

GO:0031098

GO:0031410

GO:0032147

GO:0032872

GO:0034641

GO:0036289

GO:0043167

GO:0043226

GO:0043497

GO:0043539

GO:0045893

GO:0046872

GO:0048471

GO:0070371

GO:0071902

GO:0090170

GO:0097110

GO:1903800

GO:2000641

HGNC:6842

HPA051993

Hs.72241.1.S1_3p_a_at

ILMN_1657968

ILMN_1752423

IPR000719

IPR008271

IPR011009

IPR017441

L11285

L11285_at

LRG_750

LRG_750t1

MAP2K2

MAP2K2-201

MIM:601263

MIM:615280

NM_030662

NP_109587

PF00069

PH_hs_0029886

SM00220

TC19001058.hg

UPI000012F489

XM_006722799

XM_017026989

XP_006722862

XP_016882478

Participant Of

output

Anthrax LF cleaves target cell MAP2K2 (MEK2)

Other forms of this molecule

p-S222,S226-MAP2K2 [cytosol]

MAP2K2 [cytosol]

p-S,T-MAP2K2 [cytosol]

MAP2K2(11-400) [cytosol]

Disease

Name	Identifier	Synonyms
anthrax disease	7427

Cross References

RefSeq

NP_109587.1

ZINC - World Drugs

MP2K2_HUMAN

OpenTargets

ENSG00000126934

ZINC - FDA approved

MP2K2_HUMAN

ZINC - Substances

MP2K2_HUMAN

ZINC target

P36507

ZINC - Biogenic

MP2K2_HUMAN

PRO

P36507

PDB

1S9I, 4H3Q

ZINC - Investigational

MP2K2_HUMAN

Target Pathogen

5b354852be737e166372ed6c

IntEnz

2.7.12.2

HPA

ENSG00000126934-MAP2K2

GeneCards

P36507

Ensembl

ENSP00000262948, ENSG00000126934, ENST00000262948

Orphanet

16378

ZINC - Predictions - Purchasable

MP2K2_HUMAN

HMDB Protein

HMDBP09528

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.839	7
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF [cytosol] (R-HSA-167224) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.802	9
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.745	5
UniProt:Q8IVT5 KSR1	5	p-S311,Y552 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y552 KSR1 [cytosol] (R-HSA-5672656) p-S311 KSR1 [cytosol] (R-HSA-5672652) KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654)	0.659	8
UniProt:Q96II5 Q96II5			0.601	4
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:Q92905 COPS5	2	COPS5 [cytosol] (R-HSA-416963) COPS5 [nucleoplasm] (R-HSA-5697019)	0.553	2
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.543	10
UniProt:P11142 HSPA8	10	HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	3
UniProt:P68366 TUBA4A	9	TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [cytosol] (R-HSA-191694) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	3
UniProt:Q61097	5	Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672654) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.508	2

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