Reactome | 3x4Hyp-5Hyl-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL4A6 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-2022979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

4-Hyp 5-Hyl collagen alpha-6(IV) propeptide, COL4A6, CO4A6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14031 COL4A6

Gene Names

COL4A6

Chain

signal peptide:1-22, chain:23-1691

Reference Genes

BioGPS Gene:1288 COL4A6

COSMIC (genes):COL4A6 COL4A6

CTD Gene:1288 COL4A6

dbSNP Gene:1288 COL4A6

ENSEMBL:ENSG00000197565 COL4A6

ENSEMBL_homo_sapiens_GENE:ENSG00000197565.17 COL4A6

HGNC:2208 COL4A6

KEGG Gene (Homo sapiens):1288 COL4A6

Monarch:1288 COL4A6

NCBI Gene:1288 COL4A6

OMIM:303631 COL4A6

UCSC:Q14031 COL4A6

Reference Transcript

Other Identifiers

11725910_a_at

11741797_a_at

11750015_a_at

11751887_a_at

11751888_x_at

11751893_a_at

1288

17113195

211473_PM_s_at

211473_s_at

213992_PM_at

213992_at

39939_at

4017539

4017540

4017541

4017542

4017543

4017544

4017545

4017547

4017548

4017549

4017550

4017551

4017552

4017553

4017556

4017557

4017558

4017560

4017561

4017563

4017564

4017565

4017567

4017568

4017569

4017570

4017571

4017577

4017578

4017579

4017580

4017581

4017582

4017583

4017584

4017586

4017589

4017592

4017593

4017594

4017595

4017596

4017597

4017598

4017599

4017601

4017603

4017605

4017607

4017608

4017609

4017611

4017613

4017614

4017615

4017617

4017620

4017625

4017626

4017632

4017633

4017634

4017661

4017677

4017678

4017679

779_at

8174389

A_23_P217379

D21337_at

GE83658

GE88012

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005587

GO:0005604

GO:0005615

GO:0005783

GO:0005788

GO:0007155

GO:0023052

GO:0030020

GO:0030198

GO:0030312

GO:0031012

GO:0038063

GO:0043226

GO:0062023

GO:0071230

HMNXSV003029591

HMNXSV003040585

Hs.408.2.S1_3p_at

ILMN_1675857

ILMN_1811289

ILMN_1813021

PH_hs_0000049

TC0X001267.hg

g496977_3p_a_at

Participates

as a member of

Alpha-6(IV) chains [endoplasmic reticulum lumen] (Homo sapiens)

as a candidate of

4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

3x4Hyp-GlcGalHyl-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL4A6 [endoplasmic reticulum lumen]

GlcGalHyl-COL4A6 [endoplasmic reticulum lumen]

GalHyl-COL4A6 [endoplasmic reticulum lumen]

COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL4A6 [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL4A6 [endoplasmic reticulum lumen]

5Hyl-COL4A6 [endoplasmic reticulum lumen]

5-sulfiliminyl collagen alpha-6(IV) chain [extracellular region]

4-Hyp 5-sulfiliminyl collagen alpha-6(IV) chain [extracellular region]

3,4-Hyp 5-sulfiliminyl collagen alpha-6(IV) chain [extracellular region]

GlcGalHyl-COL4A6(23-?) [extracellular region]

3x4Hyp-COL4A6(?-1691) [extracellular region]

3x4Hyp-GalHyl-COL4A6(?-1691) [extracellular region]

3x4Hyp-5Hyl-COL4A6(23-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A6(23-?) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A6(23-?) [extracellular region]

COL4A6(?-1691) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A6(?-1691) [extracellular region]

5Hyl-COL4A6(23-?) [extracellular region]

GalHyl-COL4A6(?-1691) [extracellular region]

5Hyl-COL4A6(?-1691) [extracellular region]

GlcGalHyl-COL4A6(?-1691) [extracellular region]

3x4Hyp-3Hyp-COL4A6(?-1691) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A6(?-1691) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A6(23-?) [extracellular region]

3x4Hyp-GalHyl-COL4A6(23-?) [extracellular region]

GalHyl-COL4A6(23-?) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A6(23-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A6(?-1691) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A6(?-1691) [extracellular region]

COL4A6(23-?) [extracellular region]

3x4Hyp-5Hyl-COL4A6(?-1691) [extracellular region]

3x4Hyp-3Hyp-COL4A6(23-?) [extracellular region]

3x4Hyp-COL4A6(23-?) [extracellular region]

3x4Hyp-3Hyp-COL4A6 [extracellular region]

5Hyl-COL4A6 [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A6 [extracellular region]

3x4Hyp-COL4A6 [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A6 [extracellular region]

3x4Hyp-GalHyl-COL4A6 [extracellular region]

GalHyl-COL4A6 [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A6 [extracellular region]

3x4Hyp-GlcGalHyl-COL4A6 [extracellular region]

3x4Hyp-5Hyl-COL4A6 [extracellular region]

COL4A6 [extracellular region]

GlcGalHyl-COL4A6 [extracellular region]

Inferred To

Col4a6 [endoplasmic reticulum lumen] (Mus musculus)

Col4a6 [endoplasmic reticulum lumen] (Rattus norvegicus)

COL4A6 [endoplasmic reticulum lumen] (Bos taurus)

COL4A6 [endoplasmic reticulum lumen] (Canis familiaris)

COL4A6 [endoplasmic reticulum lumen] (Sus scrofa)

col4a6 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,5R)-5-hydroxylysine at unknown position

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Cross References

RefSeq

NP_001838.2, NP_001274689.1, NP_378667.1

OpenTargets

ENSG00000197565

HPA

ENSG00000197565-COL4A6

GeneCards

Q14031

Ensembl

ENSG00000197565, ENSP00000361290, ENST00000334504, ENSP00000334733, ENST00000372216

PRO

Q14031

Pharos - Targets

Q14031

Orphanet

15775

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3