Reactome | APH1B [plasma membrane]

APH1B [plasma membrane]

Stable Identifier

R-HSA-157340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

APH-1B

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        gamma-secretase cleaves EPHB2 (Homo sapiens)
        
        gamma-secretase complex [plasma membrane] (Homo sapiens)
        
        APH-1 [plasma membrane] (Homo sapiens)
        
        APH1B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WW43 APH1B

Gene Names

APH1B, PSFL, UNQ688/PRO1328

Chain

chain:1-257

Reference Genes

BioGPS Gene:83464 APH1B

COSMIC (genes):APH1B APH1B

CTD Gene:83464 APH1B

dbSNP Gene:83464 APH1B

ENSEMBL:ENSG00000138613 APH1B

ENSEMBL_homo_sapiens_GENE:ENSG00000138613.14 APH1B

HGNC:24080 APH1B

KEGG Gene (Homo sapiens):83464 APH1B

Monarch:83464 APH1B

NCBI Gene:83464 APH1B

OMIM:607630 APH1B

UCSC:Q8WW43 APH1B

Reference Transcript

Other Identifiers

11720067_a_at

11720068_a_at

11740601_a_at

11740602_s_at

11740603_a_at

11756680_a_at

16801862

221036_PM_s_at

221036_s_at

226358_PM_at

226358_at

3010811

3597527

3597528

3597530

3597533

3597537

3597539

3597540

3597541

3597542

3597544

3597545

3597547

62125_at

65643_at

7984124

83464

91572_at

A_14_P102504

A_23_P205997

GE86938

GO:0000139

GO:0005515

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0007219

GO:0007220

GO:0010008

GO:0010950

GO:0016020

GO:0016485

GO:0023052

GO:0030133

GO:0030674

GO:0031293

GO:0031410

GO:0034205

GO:0042987

GO:0043085

GO:0043226

GO:0051604

GO:0060090

GO:0061133

GO:0070765

GO:0098772

HMNXSV003003928

Hs.29894.0.A1_3p_at

ILMN_1767816

ILMN_1862217

PH_hs_0003138

PH_hs_0034630

TC15000582.hg

g13775223_3p_s_at

Participates

as a member of

APH-1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

APH1B [endosome membrane]

Inferred To

aph1b [plasma membrane] (Danio rerio)

aph-1 [plasma membrane] (Caenorhabditis elegans)

aph-1 [plasma membrane] (Drosophila melanogaster)

APH1B [plasma membrane] (Bos taurus)

APH1B [plasma membrane] (Canis familiaris)

APH1B [plasma membrane] (Sus scrofa)

Aph1b [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_001139118.1, NP_112591.2

OpenTargets

ENSG00000138613

GeneCards

Q8WW43

HPA

ENSG00000138613-APH1B

Ensembl

ENSP00000261879, ENST00000380343, ENSP00000369700, ENST00000261879, ENSG00000138613

PRO

Q8WW43

Pharos - Targets

Q8WW43

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3