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PRKACA [ciliary base]
Stable Identifier
R-HSA-5610402
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
PKA C-alpha, cAMP-dependent protein kinase, alpha-catalytic subunit
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
PKA phosphorylates GLI1 (Homo sapiens)
PKA catalytic subunit [ciliary base] (Homo sapiens)
PRKACA [ciliary base] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
PKA phosphorylates GLI2 (Homo sapiens)
PKA catalytic subunit [ciliary base] (Homo sapiens)
PRKACA [ciliary base] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
PKA phosphorylates GLI3 (Homo sapiens)
PKA catalytic subunit [ciliary base] (Homo sapiens)
PRKACA [ciliary base] (Homo sapiens)
cAMP dissociates PKA, promoting GLI processing (Homo sapiens)
PKA catalytic subunit [ciliary base] (Homo sapiens)
PRKACA [ciliary base] (Homo sapiens)
PKA tetramer [ciliary base] (Homo sapiens)
PKA catalytic subunit [ciliary base] (Homo sapiens)
PRKACA [ciliary base] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17612 PRKACA
Gene Names
PRKACA, PKACA
Chain
initiator methionine:, chain:2-351
Reference Genes
BioGPS Gene:5566 PRKACA
COSMIC (genes):PRKACA PRKACA
CTD Gene:5566 PRKACA
dbSNP Gene:5566 PRKACA
ENSEMBL:ENSG00000072062 PRKACA
HGNC:9380 PRKACA
KEGG:hsa:5566 PRKACA
Monarch:5566 PRKACA
NCBI Gene:5566 PRKACA
OMIM:601639 PRKACA
UCSC:P17612 PRKACA
Reference Transcript
RefSeq:NM_002730.3 PRKACA
RefSeq:NM_001304349.1 PRKACA
RefSeq:NM_207518.2 PRKACA
Other Identifiers
11716146_x_at
11735763_a_at
11757881_s_at
11760372_at
16869570
202801_PM_at
202801_at
216234_3p_s_at
216234_PM_s_at
216234_s_at
3852519
3852520
3852521
3852522
3852523
3852524
3852525
3852526
3852528
3852530
3852531
3852532
3852533
3852534
3852535
3852536
3852537
3852539
3852540
3852541
3852542
3852543
3852544
3852546
3852547
3852548
3852551
3852552
3852553
3852554
3852555
3852556
3852557
3852561
3852562
3852563
3852564
438_at
5566
568_at
569_g_at
69082_at
8034762
A_24_P399630
A_24_P408206
GE59698
GO:0000287
GO:0001669
GO:0001707
GO:0001843
GO:0002027
GO:0003014
GO:0003091
GO:0003824
GO:0004672
GO:0004674
GO:0004679
GO:0004691
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005929
GO:0005930
GO:0005952
GO:0006397
GO:0006468
GO:0006611
GO:0006886
GO:0006913
GO:0007189
GO:0007193
GO:0010737
GO:0010881
GO:0016020
GO:0016071
GO:0016241
GO:0016607
GO:0016740
GO:0018105
GO:0019221
GO:0019901
GO:0019904
GO:0022414
GO:0030145
GO:0030163
GO:0031410
GO:0031514
GO:0031588
GO:0031594
GO:0031625
GO:0032024
GO:0032703
GO:0034237
GO:0034380
GO:0034605
GO:0034704
GO:0035694
GO:0036126
GO:0043226
GO:0044853
GO:0045542
GO:0045667
GO:0045722
GO:0045879
GO:0046827
GO:0048240
GO:0048471
GO:0050804
GO:0050850
GO:0051726
GO:0055117
GO:0061136
GO:0065003
GO:0070062
GO:0070417
GO:0070613
GO:0071333
GO:0071374
GO:0071377
GO:0071872
GO:0086064
GO:0097225
GO:0097546
GO:0098772
GO:0098978
GO:0099103
GO:0099170
GO:0106310
GO:0140096
GO:0141156
GO:1903779
GO:1904262
GO:1904539
GO:1990044
GO:2000810
HMNXSV003054641
Hs.77271.1.S1_3p_a_at
Hs.77271.1.S1_3p_at
Hs.77271.1.S1_3p_x_at
ILMN_1786195
ILMN_2395314
M80335_at
PH_hs_0022938
TC19001231.hg
X07767_at
g4506054_3p_at
Participates
as a member of
PKA catalytic subunit [ciliary base] (Homo sapiens)
Other forms of this molecule
PRKACA [cytosol]
PRKACA [nucleoplasm]
PRKACA [mitochondrial matrix]
Inferred To
PRKACA [ciliary base]
(Bos taurus)
PRKACA [ciliary base]
(Caenorhabditis elegans)
PRKACA [ciliary base]
(Canis familiaris)
PRKACA [ciliary base]
(Danio rerio)
PRKACA [ciliary base]
(Drosophila melanogaster)
PRKACA [ciliary base]
(Mus musculus)
PRKACA [ciliary base]
(Rattus norvegicus)
PRKACA [ciliary base]
(Saccharomyces cerevisiae)
PRKACA [ciliary base]
(Schizosaccharomyces pombe)
PRKACA [ciliary base]
(Sus scrofa)
PRKACA [ciliary base]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002721.1
,
NP_001291278.1
,
NP_997401.1
ZINC - World Drugs
KAPCA_HUMAN
Guide to Pharmacology - Targets
1476
OpenTargets
ENSG00000072062
ENSEMBL
ENST00000308677
,
ENSP00000309591
,
ENST00000589994
,
ENST00000672938
,
ENST00000673550
,
ENSP00000499940
,
ENSP00000500293
,
ENSP00000466651
ZINC - FDA approved
KAPCA_HUMAN
ZINC - Substances
KAPCA_HUMAN
ZINC - Biogenic
KAPCA_HUMAN
ZINC target
P17612
PRO
P17612
GlyGen
P17612
PDB
5IZF
,
6NO7
,
4AE9
,
5UZK
,
3L9L
,
6BYR
,
5IZJ
,
3L9M
,
8FE5
,
3OWP
,
5BX6
,
3POO
,
6WJF
,
5BX7
,
4AE6
,
4WB5
,
6FRX
,
4WB6
,
6WJG
,
2GU8
,
8X5L
,
3MVJ
,
3OXT
,
3L9N
,
7Y1G
,
6BYS
,
4UJA
,
6C0U
,
8FEC
,
5J5X
,
4WB7
,
4WB8
,
5N23
,
4UJB
,
3OVV
,
8FE2
,
4UJ9
,
3AMA
,
3P0M
,
4UJ1
,
3AMB
,
3VQH
,
3AGL
,
3NX8
,
4UJ2
,
6QJ7
,
3AGM
,
3OOG
ZINC - Investigational
KAPCA_HUMAN
HPA
ENSG00000072062-PRKACA
Pharos - Targets
P17612
Orphanet
PRKACA
ZINC - Predictions - Purchasable
KAPCA_HUMAN
HMDB Protein
HMDBP01352
Interactors (80)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31323 PRKAR2B
2
PRKAR2B [ciliary base]
(R-HSA-5610414)
PRKAR2B [cytosol]
(R-HSA-57842)
0.96
18
UniProt:P10644 PRKAR1A
4
PRKAR1A [cytosol]
(R-HSA-57836)
PRKAR1A [ciliary base]
(R-HSA-5610408)
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713471)
PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713476)
0.958
17
UniProt:P31321 PRKAR1B
2
PRKAR1B [cytosol]
(R-HSA-57838)
PRKAR1B [ciliary base]
(R-HSA-5610409)
0.89
12
UniProt:Q92667 AKAP1
2
AKAP1 [cytosol]
(R-HSA-992752)
AKAP1 [mitochondrial outer membrane]
(R-HSA-8951815)
0.837
7
UniProt:P13861 PRKAR2A
2
PRKAR2A [cytosol]
(R-HSA-57840)
PRKAR2A [ciliary base]
(R-HSA-5610412)
0.759
4
UniProt:P49841 GSK3B
4
GSK3B [cytosol]
(R-HSA-2997551)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [nucleoplasm]
(R-HSA-2022823)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
0.741
7
UniProt:P22694 PRKACB
3
PRKACB [ciliary base]
(R-HSA-5610404)
PRKACB [cytosol]
(R-HSA-57846)
PRKACB [nucleoplasm]
(R-HSA-111937)
0.725
7
UniProt:O95292 VAPB
2
VAPB [Golgi membrane]
(R-HSA-9715115)
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
0.725
5
UniProt:Q96SN8 CDK5RAP2
1
CDK5RAP2 [cytosol]
(R-HSA-380282)
0.725
6
UniProt:Q9P0L0 VAPA
4
VAPA [azurophil granule membrane]
(R-HSA-6799364)
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [cytosol]
(R-HSA-9609920)
0.725
5
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.725
4
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.666
4
UniProt:Q8N6U8 GPR161
2
GPR161 [ciliary membrane]
(R-HSA-5610373)
GPR161 [endocytic vesicle membrane]
(R-HSA-5635021)
0.643
4
UniProt:Q9UKA4 AKA11
0.643
3
UniProt:Q9Y2D5 PLAK2
0.643
3
UniProt:Q9P0M2 AKA7G
0.643
3
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.643
4
UniProt:Q5VU43 MYOME
0.643
3
UniProt:Q99996 AKAP9
3
AKAP9(1-1118)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802267)
AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802514)
AKAP9 [cytosol]
(R-HSA-380260)
0.643
3
UniProt:P59215
1
GNAO1 [plasma membrane]
(R-RNO-2997536)
0.591
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.59
6
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.59
2
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.581
3
UniProt:Q9NQ31 AKIP1
0.581
4
UniProt:Q9Y2B9 IPKG
0.564
2
UniProt:P15036 ETS2
2
ETS2 [nucleoplasm]
(R-HSA-1629811)
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
0.556
3
UniProt:P35520 CBS
1
PXLP-K119-CBS [cytosol]
(R-HSA-1614563)
0.556
3
UniProt:Q969W3 VCF1
0.556
3
UniProt:Q3SY56 SP6
0.556
3
UniProt:O14531 DPYSL4
3
p-S544-DPYSL4 [cytosol]
(R-HSA-399808)
p-Y-DPYSL4 [cytosol]
(R-HSA-399794)
DPYSL4 [cytosol]
(R-HSA-398126)
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.556
3
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:O60784-2 TOM1
0.556
3
UniProt:P26378-2 P263782
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:Q8NE08 Q8NE08
0.556
3
UniProt:Q4VBR4 Q4VBR4
0.556
3
UniProt:P61513 RPL37A
1
RPL37A [cytosol]
(R-HSA-72468)
0.556
3
UniProt:Q5T686 AVPI1
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:P54819 AK2
1
AK2 [mitochondrial intermembrane space]
(R-HSA-57822)
0.556
3
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.556
3
UniProt:P23276 KEL
1
KEL [plasma membrane]
(R-HSA-5694121)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:Q16549 PCSK7
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.556
3
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.556
3
UniProt:O14494 PLPP1
1
PLPP1 [plasma membrane]
(R-HSA-76106)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
IntAct:EBI-25834291 CCSB
0.556
3
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.556
3
UniProt:P00491 PNP
7
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [extracellular region]
(R-HSA-6806505)
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
PNP [cytosol]
(R-HSA-61933)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP R234P [cytosol]
(R-HSA-9735772)
0.556
3
UniProt:P23560-2 BDNF
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q13387-4 MAPK8IP2
0.556
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.556
3
UniProt:Q99720-4 SIGMAR1
0.556
3
UniProt:Q9C010-2 PKIB
0.556
3
UniProt:Q9HC16 APOBEC3G
0.544
6
UniProt:Q13946 PDE7A
1
PDE7A [cytosol]
(R-HSA-418525)
0.527
2
UniProt:P0DTD1-PRO_0000449630 REP
0.527
2
UniProt:P61925 IPKA
0.527
2
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:P22612 PRKACG
3
PRKACG [ciliary base]
(R-HSA-5610405)
PRKACG [cytosol]
(R-HSA-57848)
PRKACG [nucleoplasm]
(R-HSA-111938)
0.527
2
UniProt:P12369 Prkar2b
3
cAMP-dependent protein kinase type II-beta regulatory subunit [cytosol]
(R-RNO-446975)
PRKAR2B [ciliary base]
(R-RNO-5610414)
PRKAR2B [cytosol]
(R-RNO-57842)
0.499
2
UniProt:Q9GZX7 AICDA
1
AICDA [nucleoplasm]
(R-HSA-452477)
0.499
3
UniProt:P46108-2 CRK
0.488
2
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