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AATF [cytosol]
Stable Identifier
R-HSA-205071
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CHE1, Protein AATF, AATF_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)
AATF [cytosol] (Homo sapiens)
NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)
AATF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NY61 AATF
Gene Names
AATF, CHE1, DED, HSPC277
Chain
initiator methionine:, chain:2-560
Reference Genes
BioGPS Gene:26574 AATF
CTD Gene:26574 AATF
dbSNP Gene:26574 AATF
ENSEMBL:ENSG00000275700 AATF
HGNC:19235 AATF
KEGG:hsa:26574 AATF
Monarch:26574 AATF
NCBI Gene:26574 AATF
OMIM:608463 AATF
UCSC:Q9NY61 AATF
Reference Transcript
RefSeq:NM_012138.4 AATF
Other Identifiers
11732137_at
16833518
209165_PM_at
209165_at
26574
32117_at
3719363
3719364
3719365
3719366
3719367
3719368
3719369
3719370
3719371
3719372
3719373
3719377
3719379
3719380
3719381
3719382
3719390
3719391
3719392
3719393
3719394
3719395
3719399
3719400
3719401
3719402
3719403
3719404
3719405
3719406
3719407
3719408
8006690
A_14_P113500
A_14_P113553
A_23_P89460
A_24_P262395
GE55294
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005730
GO:0005737
GO:0007155
GO:0007346
GO:0032040
GO:0040016
GO:0042254
GO:0042274
GO:0042985
GO:0043226
GO:0043522
GO:2001234
HMNXSV003044137
ILMN_1703743
PH_hs_0023719
TC17000444.hg
g5813798_3p_at
Participates
as a component of
NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)
as an input of
NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)
Cross References
RefSeq
NP_036270.1
OpenTargets
ENSG00000275700
ENSEMBL
ENSP00000481894
,
ENST00000620004
,
ENSG00000276072
,
ENST00000619387
,
ENSG00000275700
,
ENSP00000477848
HPA
ENSG00000275700-AATF
GeneCards
AATF
PRO
Q9NY61
Pharos - Targets
Q9NY61
GlyGen
Q9NY61
PDB
5W6A
,
7MQ9
,
7MQ8
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NEJ9 NGDN
0.806
6
UniProt:O96017 CHEK2
3
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
0.602
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.556
3
UniProt:Q8NEH6 MNS1
0.556
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.544
2
UniProt:Q13315 ATM
5
ATM [cytosol]
(R-HSA-9665171)
ATM [peroxisomal matrix]
(R-HSA-9665169)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [nucleoplasm]
(R-HSA-69484)
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
0.544
3
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.543
4
UniProt:Q86TJ2 TADA2B
1
TADA2B [nucleoplasm]
(R-HSA-3322963)
0.543
4
UniProt:Q92830 KAT2A
1
KAT2A [nucleoplasm]
(R-HSA-3006516)
0.543
4
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.527
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
2
UniProt:Q9BSC4 NOL10
0.527
3
UniProt:P0DTD1-PRO_0000449626 REP
0.527
2
UniProt:Q9H0A0 NAT10
1
NAT10 [nucleoplasm]
(R-HSA-6791008)
0.527
3
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.524
3
UniProt:Q99708 RBBP8
4
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
RBBP8 [nucleoplasm]
(R-HSA-912399)
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
0.508
3
UniProt:Q6ZWQ9 Q6ZWQ9
0.508
3
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.508
2
UniProt:P52435 POLR2J
1
POLR2J [nucleoplasm]
(R-HSA-63531)
0.508
2
UniProt:P62753 RPS6
4
RPS6 [cytosol]
(R-HSA-72381)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
RPS6 [nucleoplasm]
(R-HSA-6790606)
0.483
3
UniProt:Q8WYQ5 DGCR8
1
DGCR8 [nucleoplasm]
(R-HSA-1482509)
0.483
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
UniProt:P10636 MAPT
3
MAPT [cytosol]
(R-HSA-201574)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT(422-758) [cytosol]
(R-HSA-350642)
0.471
2
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