Reactome | AATF [cytosol]

AATF [cytosol]

Stable Identifier

R-HSA-205071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CHE1, Protein AATF, AATF_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NY61 AATF

Gene Names

AATF, CHE1, DED, HSPC277

Chain

initiator methionine:1, chain:2-560

Reference Genes

BioGPS Gene:26574 AATF

CTD Gene:26574 AATF

dbSNP Gene:26574 AATF

ENSEMBL:ENSG00000275700 AATF

ENSEMBL:ENSG00000276072 AATF

HGNC:19235 AATF

KEGG Gene (Homo sapiens):26574 AATF

Monarch:26574 AATF

NCBI Gene:26574 AATF

OMIM:608463 AATF

UCSC:Q9NY61 AATF

Reference Transcript

RefSeq:NM_012138.3 AATF

Other Identifiers

0004150162

11732137_at

16833518

209165_at

26574

32117_at

3719363

3719364

3719365

3719366

3719367

3719368

3719369

3719370

3719371

3719372

3719373

3719377

3719379

3719380

3719381

3719382

3719390

3719392

3719395

3719404

3719405

3719406

3719407

3719408

4940

5W6A

8006690

A0A087WW41

A0A087WWS8

A_23_P89460

A_24_P262395

AAD52016

AAF28955

AAH00591

AATF

AATF-208

AATF-210

AC003103

AF083208

AF161395

AJ249940

AK057229

BAG51888

BC000591

CAB57451

CCDS32632

CH471199

EAW57575

ENSG00000275700

ENSG00000276072

ENSP00000477848

ENSP00000481894

ENST00000619387

ENST00000619387.4

ENST00000620004

EntrezGene:26574

EntrezGene:AATF

g5813798_3p_at

GE55294

GO:0000278

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005794

GO:0006357

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0007346

GO:0008092

GO:0008150

GO:0008219

GO:0009058

GO:0019899

GO:0019901

GO:0032929

GO:0032991

GO:0034641

GO:0042254

GO:0042985

GO:0043066

GO:0043226

GO:0043522

GO:0044798

GO:0045893

GO:0045944

GO:0048156

GO:2000378

GO:2001234

HGNC:19235

HPA004940

ILMN_1703743

IPR012617

IPR025160

IPR039223

MIM:608463

NM_012138

NP_036270

PF08164

PF13339

PH_hs_0023719

TC17000444.hg

UPI000006E3DE

XM_011524611

XP_011522913

XR_934439

Participant Of

hasComponent

NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane]

input

NRAGE sequesters CHE1 in the cytoplasm

Cross References

RefSeq

NP_036270.1

OpenTargets

ENSG00000275700

GeneCards

Q9NY61

HPA

ENSG00000275700-AATF

Ensembl

ENSP00000481894, ENSG00000276072, ENSP00000477848, ENSG00000275700, ENST00000620004, ENST00000619387

PRO

Q9NY61

PDB

5W6A

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEJ9 NGDN			0.675	4
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.602	4
UniProt:Q8NEH6 MNS1			0.556	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.544	2
UniProt:Q13315 ATM	5	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) ATM [nucleoplasm] (R-HSA-69484) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.544	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.543	4
UniProt:Q86TJ2 TADA2B	1	TADA2B [nucleoplasm] (R-HSA-3322963)	0.543	4
UniProt:Q92830 KAT2A	1	KAT2A [nucleoplasm] (R-HSA-3006516)	0.543	4
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.524	3
UniProt:P10636 MAPT	3	MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642) MAPT [cytosol] (R-HSA-201574)	0.524	2
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.508	2
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.508	2
UniProt:Q6ZWQ9	2	Myl12a [cytosol] (R-MMU-390735) phospho-Myl12a [cytosol] (R-MMU-390749)	0.508	3
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399)	0.508	3