Reactome | AATF [cytosol]

AATF [cytosol]

Stable Identifier

R-HSA-205071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CHE1, Protein AATF, AATF_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NY61 AATF

Gene Names

AATF, CHE1, DED, HSPC277

Chain

initiator methionine:1, chain:2-560

Reference Genes

BioGPS Gene:26574 AATF

CTD Gene:26574 AATF

dbSNP Gene:26574 AATF

ENSEMBL:ENSG00000275700 AATF

ENSEMBL:ENSG00000275700.6 AATF

ENSEMBL:ENSG00000276072.2 AATF

HGNC:19235 AATF

KEGG Gene (Homo sapiens):26574 AATF

Monarch:26574 AATF

NCBI Gene:26574 AATF

OMIM:608463 AATF

UCSC:Q9NY61 AATF

Reference Transcript

RefSeq:NM_012138.3 AATF

Other Identifiers

11732137_at

16833518

209165_PM_at

209165_at

26574

32117_at

3719363

3719364

3719365

3719366

3719367

3719368

3719369

3719370

3719371

3719372

3719373

3719377

3719379

3719380

3719381

3719382

3719390

3719392

3719395

3719404

3719405

3719406

3719407

3719408

8006690

A_23_P89460

A_24_P262395

GE55294

GO:0000278

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0005737

GO:0005794

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0007155

GO:0007346

GO:0008092

GO:0012501

GO:0019901

GO:0023052

GO:0032929

GO:0040016

GO:0042254

GO:0042985

GO:0043066

GO:0043226

GO:0043522

GO:0045893

GO:0045944

GO:0048156

GO:0048856

GO:1901135

GO:2000378

GO:2001234

HMNXSV003044137

ILMN_1703743

PH_hs_0023719

TC17000444.hg

g5813798_3p_at

Participates

as a component of

NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)

as an input of

NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)

Cross References

RefSeq

NP_036270.1

OpenTargets

ENSG00000275700

GeneCards

Q9NY61

HPA

ENSG00000275700-AATF

Ensembl

ENSG00000275700, ENSP00000477848, ENST00000619387, ENSG00000276072, ENSP00000481894, ENST00000620004

PRO

Q9NY61

Pharos - Targets

Q9NY61

PDB

5W6A, 7MQ9, 7MQ8

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEJ9 NGDN			0.675	4
UniProt:O96017 CHEK2	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.602	4
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:P63000 RAC1	6	GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8NEH6 MNS1			0.556	3
UniProt:Q13315 ATM	5	ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.544	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.544	2
UniProt:Q92830 KAT2A	1	KAT2A [nucleoplasm] (R-HSA-3006516)	0.543	4
UniProt:Q86TJ2 TADA2B	1	TADA2B [nucleoplasm] (R-HSA-3322963)	0.543	4
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.543	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P0DTD1-PRO_0000449626 REP			0.527	2
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.524	3
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.508	2
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.508	2
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.508	3
UniProt:Q6ZWQ9 Q6ZWQ9			0.508	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.471	2

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