Reactome | NEXT4 [plasma membrane]

NEXT4 [plasma membrane]

Stable Identifier

R-HSA-157641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NOTCH4(1432-2003), Notch 4 NEXT fragment

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External Reference Information

External Reference

UniProt:Q99466 NOTCH4

Gene Names

NOTCH4, INT3

Chain

signal peptide:1-23, chain:24-2003, chain:1432-2003, chain:1467-2003

Reference Genes

BioGPS Gene:4855 NOTCH4

COSMIC (genes):NOTCH4 NOTCH4

CTD Gene:4855 NOTCH4

dbSNP Gene:4855 NOTCH4

ENSEMBL:ENSG00000204301 NOTCH4

ENSEMBL:ENSG00000204301.6 NOTCH4

ENSEMBL:ENSG00000223355.5 NOTCH4

ENSEMBL:ENSG00000234876.5 NOTCH4

ENSEMBL:ENSG00000238196.5 NOTCH4

HGNC:7884 NOTCH4

KEGG Gene (Homo sapiens):4855 NOTCH4

Monarch:4855 NOTCH4

NCBI Gene:4855 NOTCH4

OMIM:164951 NOTCH4

UCSC:Q99466 NOTCH4

Reference Transcript

RefSeq:NM_004557.3 NOTCH4

Other Identifiers

0003190440

11721965_a_at

11746752_a_at

11748539_a_at

11751705_a_at

17017814

17027038

17029639

17034630

17037128

17039839

17042335

205247_PM_at

205247_at

2949899

2949900

2949902

2949903

2949904

2949905

2949906

2949907

2949909

2949911

2949912

2949913

2949914

2949915

2949916

2949917

2949918

2949919

2949921

2949922

2949927

2949928

2949929

2949932

2949933

2949934

2949935

2949936

2949937

2949939

2949940

2949941

2949942

2949945

2949946

2949947

2949949

2949950

2949952

2949954

2949955

2949956

2949957

2949958

2949959

2949960

2949962

39048_at

4855

8125383

A_23_P365614

A_24_P26496

GE59595

GO:0000122

GO:0000139

GO:0001569

GO:0001709

GO:0001763

GO:0001837

GO:0001886

GO:0001944

GO:0002376

GO:0003674

GO:0005112

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0005887

GO:0006351

GO:0006355

GO:0007155

GO:0007219

GO:0007221

GO:0007275

GO:0008150

GO:0009986

GO:0016020

GO:0016021

GO:0023052

GO:0030097

GO:0030154

GO:0030879

GO:0038023

GO:0042060

GO:0043167

GO:0043226

GO:0045446

GO:0045596

GO:0045602

GO:0045893

GO:0046872

GO:0048856

GO:0050793

GO:0060354

GO:2000048

HMNXSV003054488

Hs.11689.0.S2_3p_at

ILMN_1711157

PH_hs_0025474

TC06001564.hg

TC6_apd_hap1000098.hg

TC6_cox_hap2000190.hg

TC6_mann_hap4000155.hg

TC6_mcf_hap5000165.hg

TC6_qbl_hap6000179.hg

TC6_ssto_hap7000159.hg

U89335_cds2_at

Participates

as an output of

ADAM10 cleaves NOTCH4 (Homo sapiens)

as an input of

Gamma-secretase cleaves NOTCH4 (Homo sapiens)

Other forms of this molecule

NOTCH4(1432-1466) [plasma membrane]

p-4S-NICD4 [cytosol]

NICD4 [cytosol]

NICD4 [nucleoplasm]

p-NICD4 [nucleoplasm]

PolyUb-p-NICD4 [nucleoplasm]

Glc,GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]

Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]

Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]

FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) [plasma membrane]

FRINGE-modified NOTCH4 Extracellular fragment (NECD4) [Golgi membrane]

Pre-NOTCH4 [endoplasmic reticulum membrane]

12xFucT-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]

12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]

12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [Golgi membrane]

NOTCH4(1337-2003) [plasma membrane]

12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region]

12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) [Golgi membrane]

NOTCH4(1337-2003) [Golgi membrane]

Cross References

RefSeq

NP_004548.3

Guide to Pharmacology - Targets

2862

OpenTargets

ENSG00000204301

GeneCards

Q99466

HPA

ENSG00000204301-NOTCH4

ZINC - Substances

NOTC4_HUMAN

ZINC target

Q99466

Ensembl

ENSP00000408335, ENSG00000234876, ENSG00000223355, ENSG00000238196, ENSP00000364163, ENSP00000401321, ENST00000457094, ENSP00000403447, ENSG00000204301, ENST00000375023, ENST00000425600, ENST00000439349

PRO

Q99466

Pharos - Targets

Q99466

ZINC - Predictions - Purchasable

NOTC4_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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