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NEXT4
Stable Identifier
R-HSA-157641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NOTCH4(1432-2003), Notch 4 NEXT fragment
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NEXT4 is cleaved to produce NICD4 (Homo sapiens)
NEXT4 [plasma membrane] (Homo sapiens)
Notch 4-ligand complex is cleaved to produce NEXT4 (Homo sapiens)
NEXT4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99466 NOTCH4
Gene Names
NOTCH4, INT3
Chain
signal peptide:1-23, chain:24-2003, chain:1432-2003, chain:1467-2003
Reference Genes
BioGPS Gene:4855 NOTCH4
COSMIC (genes):NOTCH4 NOTCH4
CTD Gene:4855 NOTCH4
dbSNP Gene:4855 NOTCH4
ENSEMBL:ENSG00000204301 NOTCH4
ENSEMBL:ENSG00000223355 NOTCH4
ENSEMBL:ENSG00000234876 NOTCH4
ENSEMBL:ENSG00000238196 NOTCH4
HGNC:7884 NOTCH4
KEGG Gene (Homo sapiens):hsa:4855 NOTCH4
Monarch:4855 NOTCH4
NCBI Gene:4855 NOTCH4
OMIM:164951 NOTCH4
UCSC:Q99466 NOTCH4
Reference Transcript
RefSeq:NM_004557.3 NOTCH4
Other Identifiers
0003190440
11721965_a_at
11746752_a_at
11748539_a_at
11751705_a_at
17017814
17027038
17029639
17034630
17037128
17039839
17042335
205247_at
2949902
2949903
2949904
2949905
2949906
2949907
2949909
2949911
2949912
2949913
2949914
2949915
2949916
2949917
2949918
2949919
2949921
2949922
2949927
2949928
2949929
2949932
2949933
2949934
2949935
2949936
2949937
2949939
2949940
2949941
2949942
2949945
2949946
2949947
2949949
2949950
2949952
2949954
2949955
2949956
2949957
2949958
2949959
2949960
2949962
39048_at
4855
8125383
A0A140T8Y6
A0A140T9R5
A0A1U9X938
A0A1U9X983
A0A1U9X989
A_23_P365614
A_24_P26496
AAC32288
AAC63097
AB023961
AB024520
AB024578
AL662884
AQY77315
AQY77334
BAA09708
BAA13116
BAA88951
BAA88952
BAB20317
BX284686
BX284927
CAI18362
CAM25850
CAM26209
CAQ09631
CAQ10706
CCDS34420
CR812478
CR933878
D63395
D86566
ENSG00000204301
ENSG00000223355
ENSG00000234876
ENSG00000238196
ENSP00000364163
ENSP00000401321
ENSP00000403447
ENSP00000408335
ENST00000375023
ENST00000425600
ENST00000439349
ENST00000457094
EntrezGene:4855
GE59595
GO:0000139
GO:0001569
GO:0001709
GO:0001763
GO:0001886
GO:0004872
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005789
GO:0005829
GO:0005886
GO:0005887
GO:0006351
GO:0006355
GO:0006367
GO:0007219
GO:0007220
GO:0007221
GO:0007275
GO:0009790
GO:0009986
GO:0016020
GO:0016021
GO:0030097
GO:0030154
GO:0030879
GO:0045446
GO:0045596
GO:0045602
GO:0045893
GO:0046872
GO:0046982
GO:0050793
HGNC:7884
Hs.11689.0.S2_3p_at
Hs.436100
ILMN_1711157
IPR000152
IPR000742
IPR000800
IPR001881
IPR002110
IPR009030
IPR010660
IPR011656
IPR013032
IPR018097
IPR020683
IPR022355
KY500847
KY500866
MIM:164951
NM_004557
NOTCH4
NOTCH4-201
NOTCH4-211
NOTCH4-221
NOTCH4-231
NP_004548
NR_134949
NR_134950
PF00008
PF00023
PF00066
PF06816
PF07645
PF07684
PF12661
PF12796
PF13857
PH_hs_0025474
PR01452
PR01983
PR01987
SM00004
SM00179
SM00181
SM00248
SM01338
SM01339
TC06001564.hg
TC6_apd_hap1000098.hg
TC6_cox_hap2000190.hg
TC6_mann_hap4000155.hg
TC6_mcf_hap5000165.hg
TC6_qbl_hap6000179.hg
TC6_ssto_hap7000159.hg
U89335
U89335_cds2_at
U95299
uc003obb.3
UPI0000130571
UPI000165DC8D
UPI000165DCE7
Participant Of
input
NEXT4 is cleaved to produce NICD4
output
Notch 4-ligand complex is cleaved to produce NEXT4
Other forms of this molecule
NICD4 [nucleoplasm]
NOTCH4(24-1431) [extracellular region]
NICD4 [cytosol]
NOTCH4(1432-1466) [plasma membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) [plasma membrane]
FRINGE-modified NOTCH4 Extracellular fragment (NECD4) [Golgi membrane]
Pre-NOTCH4 [endoplasmic reticulum membrane]
12xFucT-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [Golgi membrane]
NOTCH4(1337-2003) [plasma membrane]
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) [Golgi membrane]
NOTCH4(1337-2003) [Golgi membrane]
Inferred To
NEXT4 [plasma membrane] (Bos taurus)
NEXT4 [plasma membrane] (Canis familiaris)
NEXT4 [plasma membrane] (Drosophila melanogaster)
NEXT4 [plasma membrane] (Mus musculus)
NEXT4 [plasma membrane] (Rattus norvegicus)
NEXT4 [plasma membrane] (Sus scrofa)
NEXT4 [plasma membrane] (Taeniopygia guttata)
NEXT4 [plasma membrane] (Xenopus tropicalis)
Homologues of NEXT4 [plasma membrane] (Canis familiaris)
Homologues of NEXT4 [plasma membrane] (Mus musculus)
Homologues of NEXT4 [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_004548.3
GeneCards
Q99466
ZINC - Substances
NOTC4_HUMAN
ZINC target
Q99466
PRO
Q99466
ZINC - Predictions - Purchasable
NOTC4_HUMAN
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