Reactome | IDE [peroxisomal matrix]

IDE [peroxisomal matrix]

Stable Identifier

R-HSA-9033157

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
8077210	Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line Kuo, WL, Gehm, BD, Rosner, MR, Li, W, Keller, G	J. Biol. Chem.	1994

External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

BioGPS Gene:3416 IDE

COSMIC (genes):IDE IDE

CTD Gene:3416 IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

HGNC:5381 IDE

KEGG:hsa:3416 IDE

Monarch:3416 IDE

NCBI Gene:3416 IDE

OMIM:146680 IDE

UCSC:P14735 IDE

Reference Transcript

Participates

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

IDE [endosome lumen]

IDE [cytosol]

PolyUb-IDE [mitochondrial outer membrane]

IDE [mitochondrial outer membrane]

Inferred To

STE23 [peroxisomal matrix] (Saccharomyces cerevisiae)

Ide [peroxisomal matrix] (Drosophila melanogaster)

Ide [peroxisomal matrix] (Mus musculus)

Ide [peroxisomal matrix] (Rattus norvegicus)

ide [peroxisomal matrix] (Xenopus tropicalis)

mug138 [peroxisomal matrix] (Schizosaccharomyces pombe)

IDE [peroxisomal matrix] (Bos taurus)

IDE [peroxisomal matrix] (Canis familiaris)

IDE [peroxisomal matrix] (Dictyostelium discoideum)

IDE [peroxisomal matrix] (Gallus gallus)

IDE [peroxisomal matrix] (Sus scrofa)

Cross References

RefSeq

NP_004960.2, NP_001159418.1

Guide to Pharmacology - Targets

2371

OpenTargets

ENSG00000119912

ENSEMBL

ENSP00000265986, ENSG00000119912, ENST00000371581, ENST00000265986, ENSP00000360637

ZINC - Substances

IDE_HUMAN

ZINC target

P14735

PRO

P14735

GlyGen

P14735

PDB

4M1C, 7RZH, 7RZI, 4GS8, 7RZE, 4NXO, 3OFI, 6EDS, 5CJO, 2WK3, 4IFH, 2G49, 3QZ2, 6BFC, 6BF8, 4PES, 4PF7, 6BF7, 3CWW, 6BF9, 2JG4, 7K1F, 4PF9, 3H44, 2JBU, 2G54, 7K1D, 4IOF, 5WOB, 6MQ3, 3E4Z, 4LTE, 7RZF, 4DTT, 5UOE, 6BYZ, 2G48, 2G47, 2WC0, 7RZG, 4DWK, 6B3Q, 3N57, 2WBY, 3N56, 4QIA, 6BF6, 4RAL, 3E4A, 7K1E, 4GSC, 3E50, 6B70, 6B7Z, 6B7Y, 4PFC, 3HGZ, 2G56, 2YPU, 4GSF, 4RE9

HPA

ENSG00000119912-IDE

GeneCards

IDE

Pharos - Targets

P14735

ZINC - Predictions - Purchasable

IDE_HUMAN

HMDB Protein

HMDBP10019

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.643	3
UniProt:P10147 CCL3	2	CCL3(27-92) [extracellular region] (R-HSA-6785011) CCL3(24-92) [extracellular region] (R-HSA-443989)	0.618	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P08670 VIM	12	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) p39-VIM [cytosol] (R-HSA-9948102)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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