Reactome | TGFB1 [extracellular region]

TGFB1 [extracellular region]

Stable Identifier

R-HSA-170838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

TGF-beta-1, Transforming Growth Factor beta 1

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        TGF beta [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
        
        Dimeric TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
        
        Dimeric TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01137 TGFB1

Gene Names

TGFB1, TGFB

Chain

signal peptide:1-29, chain:30-278, chain:279-390

Reference Genes

BioGPS Gene:7040 TGFB1

COSMIC (genes):TGFB1 TGFB1

CTD Gene:7040 TGFB1

dbSNP Gene:7040 TGFB1

ENSEMBL:ENSG00000105329 TGFB1

HGNC:11766 TGFB1

KEGG Gene (Homo sapiens):7040 TGFB1

Monarch:7040 TGFB1

NCBI Gene:7040 TGFB1

OMIM:190180 TGFB1

UCSC:P01137 TGFB1

Reference Transcript

RefSeq:NM_000660.6 TGFB1

Participates

as a member of

TGF beta [extracellular region] (Homo sapiens)

as a component of

as an input of

Syndecans 2, (4) bind TGFB1 (Homo sapiens)

This entity regulates

Negatively

Other forms of this molecule

TGFB1(30-278) [extracellular region]

TGFB1(30-278) [Golgi lumen]

TGFB1 [Golgi lumen]

TGFB1(30-390) [Golgi lumen]

TGFB1 [plasma membrane]

TGFB1(30-278) [platelet alpha granule lumen]

Inferred To

TGFB1 [extracellular region] (Bos taurus)

TGFB1 [extracellular region] (Canis familiaris)

TGFB1 [extracellular region] (Danio rerio)

TGFB1 [extracellular region] (Gallus gallus)

TGFB1 [extracellular region] (Sus scrofa)

mav [extracellular region] (Drosophila melanogaster)

dbl-1 [extracellular region] (Caenorhabditis elegans)

Tgfb1 [extracellular region] (Mus musculus)

Tgfb1 [extracellular region] (Rattus norvegicus)

Ghost homologue of TGFB1 [extracellular region] (Xenopus tropicalis)

tig-2 [extracellular region] (Caenorhabditis elegans)

tig-3 [extracellular region] (Caenorhabditis elegans)

gbb [extracellular region] (Drosophila melanogaster)

Homologues of TGFB1 [extracellular region] (Caenorhabditis elegans)

Homologues of TGFB1 [extracellular region] (Drosophila melanogaster)

dpp [extracellular region] (Drosophila melanogaster)

scw [extracellular region] (Drosophila melanogaster)

unc-129 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000651.3

OpenTargets

ENSG00000105329

ZINC - Substances

TGFB1_HUMAN

GeneCards

P01137

ZINC target

P01137

PRO

P01137

Pharos - Targets

P01137

Orphanet

15606

ZINC - Predictions - Purchasable

TGFB1_HUMAN

HMDB Protein

HMDBP14566

PDB

1KLA, 7Y1T, 4KV5, 6OM2, 3KFD, 1KLC, 7Y1R, 5VQP, 6P7J, 1KLD, 5FFO

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.811	6
UniProt:Q14766-1 LTBP1			0.637	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.604	3
UniProt:Q14392 LRC32			0.564	2
UniProt:P11464 PSG1	1	PSG1 [extracellular region] (R-HSA-8870766)	0.558	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:O60711 LPXN			0.556	3
UniProt:Q5TA81 LCE2C	1	LCE2C [cytosol] (R-HSA-6814284)	0.556	3
UniProt:O14633 LCE2B	1	LCE2B [cytosol] (R-HSA-6814295)	0.556	3
IntAct:EBI-22335676 CCSB ORF ID			0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q9BYE3 LCE3D	1	LCE3D [cytosol] (R-HSA-6814297)	0.556	3
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.556	3
UniProt:Q5T752 LCE1D	1	LCE1D [cytosol] (R-HSA-6814283)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q5T7P2 LCE1A	1	LCE1A [cytosol] (R-HSA-6814305)	0.556	3
UniProt:Q5TA76 LCE3A	1	LCE3A [cytosol] (R-HSA-6814296)	0.556	3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q5TA77 LCE3B	1	LCE3B [cytosol] (R-HSA-6814269)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902)	0.556	3
UniProt:Q12841 FSTL1	3	FSTL1 [extracellular region] (R-HSA-201832) p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749)	0.544	2
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518)	0.525	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.522	2
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773) ITGAV(31-1048) [plasma membrane] (R-HSA-210013)	0.488	2

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