Reactome | GRK6 [plasma membrane]

GRK6 [plasma membrane]

Stable Identifier

R-HSA-8852159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein-coupled receptor kinase 6 ecNumber2.7.11.16/ecNumber, GRK6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43250 GRK6

Gene Names

GRK6, GPRK6

Chain

chain:1-576

Reference Genes

BioGPS Gene:2870 GRK6

COSMIC (genes):GRK6 GRK6

CTD Gene:2870 GRK6

dbSNP Gene:2870 GRK6

ENSEMBL:ENSG00000198055 GRK6

HGNC:4545 GRK6

KEGG:hsa:2870 GRK6

Monarch:2870 GRK6

NCBI Gene:2870 GRK6

OMIM:600869 GRK6

UCSC:P43250 GRK6

Reference Transcript

Participates

as a member of

GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)

Inferred To

grk6 [plasma membrane] (Danio rerio)

grk6 [plasma membrane] (Xenopus tropicalis)

GRK6 [plasma membrane] (Bos taurus)

GRK6 [plasma membrane] (Canis familiaris)

GRK6 [plasma membrane] (Gallus gallus)

GRK6 [plasma membrane] (Sus scrofa)

Grk6 [plasma membrane] (Mus musculus)

Grk6 [plasma membrane] (Rattus norvegicus)

Gprk2 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001004106.1, NP_001004105.1, NP_002073.2

Guide to Pharmacology - Targets

1470

ENSEMBL

ENSP00000347655, ENSP00000433511, ENSG00000198055, ENSP00000348230, ENST00000355472, ENST00000355958, ENST00000528793

OpenTargets

ENSG00000198055

ZINC - Substances

GRK6_HUMAN

ZINC - Biogenic

GRK6_HUMAN

ZINC target

P43250

PRO

P43250

PDB

3NYO, 2ACX, 3NYN

IntEnz

2.7.11.16

GeneCards

GRK6

HPA

ENSG00000198055-GRK6

Pharos - Targets

P43250

ZINC - Predictions - Purchasable

GRK6_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3

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