Reactome | CASP8(1-216) [cytosol]

CASP8(1-216) [cytosol]

Stable Identifier

R-HSA-933456

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casp-8 prodomain, Caspase-8 prodomain

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP8(1-216) [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP8(1-216) [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP8(1-216) [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP8(1-216) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14790 CASP8

Gene Names

CASP8, MCH5

Chain

propeptide:1-216, chain:217-374, propeptide:375-384, chain:385-479

Reference Genes

COSMIC (genes):CASP8 CASP8

dbSNP Gene:841 CASP8

ENSEMBL:ENSG00000064012 CASP8

Participates

as a member of

Casp-8/10 prodomain [cytosol] (Homo sapiens)

Other forms of this molecule

CASP8(1-374) [cytosol]

CASP8(217-374) [mitochondrial outer membrane]

CASP8(385-479) [mitochondrial outer membrane]

CASP8(385-479) [cytosol]

CASP8(375-384) [cytosol]

CASP8(217-374) [cytosol]

CASP8(1-479) [cytosol]

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.98	47
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.959	30
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.92	16
UniProt:P50591 TNFSF10	1	TNFSF10 [extracellular region] (R-HSA-66186)	0.919	20
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.817	11
UniProt:O14763 TNFRSF10B	1	TNFRSF10B [plasma membrane] (R-HSA-65505)	0.749	7
UniProt:O15519 CFLAR	1	CFLAR(1-376) [cytosol] (R-HSA-51925)	0.744	10
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.744	5
UniProt:Q92851 CASP10	4	CASP10(220-415) [cytosol] (R-HSA-933458) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-521) [cytosol] (R-HSA-933453)	0.734	6
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.725	6
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.704	4
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.704	5
UniProt:P25445-1 FAS			0.669	3
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.602	6
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.589	3
UniProt:O15519-1 CFLAR	5	M1polyUb-K351,K353-CFLAR(1-480) [cytosol] (R-HSA-9794015) CFLAR(377-480) [cytosol] (R-HSA-3465483) K63polyUb-CFLAR(1-480) [cytosol] (R-HSA-9818805) CFLAR(1-376) [cytosol] (R-HSA-3465408) CFLAR(1-480) [cytosol] (R-HSA-3371356)	0.564	2
UniProt:Q9Y572 RIPK3	8	RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3(329-518) [cytosol] (R-HSA-9686937) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933)	0.564	2
UniProt:Q96AX1 VPS33A	1	VPS33A [endosome membrane] (R-HSA-2197804)	0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q06787-7 FMR1			0.556	3
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.556	3
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.547	2
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.527	3
UniProt:O60936 NOL3			0.524	3
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.524	3
UniProt:Q969K3 RNF34	2	RNF34 [nucleoplasm] (R-HSA-6804442) RNF34 [cytosol] (R-HSA-975998)	0.508	3
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.499	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.499	3
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.499	10

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