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DAB2 [cytosol]
Stable Identifier
R-HSA-8862456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Disabled homolog 2, DAB2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
DAB2 binds LRP2 (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LDLR is bound by DAB2 and ARH (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
DAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98082 DAB2
Gene Names
DAB2, DOC2
Chain
initiator methionine:, chain:2-770
Reference Genes
BioGPS Gene:1601 DAB2
COSMIC (genes):DAB2 DAB2
CTD Gene:1601 DAB2
dbSNP Gene:1601 DAB2
ENSEMBL:ENSG00000153071 DAB2
ENSEMBL_homo_sapiens_GENE:ENSG00000153071.15 DAB2
HGNC:2662 DAB2
KEGG Gene (Homo sapiens):1601 DAB2
Monarch:1601 DAB2
NCBI Gene:1601 DAB2
OMIM:601236 DAB2
UCSC:P98082 DAB2
Reference Transcript
RefSeq:NM_001343.3 DAB2
RefSeq:NM_001244871.1 DAB2
Other Identifiers
11722355_s_at
11722356_a_at
11744796_a_at
11744797_s_at
1601
16995645
201278_PM_at
201278_at
201279_PM_s_at
201279_s_at
201280_PM_s_at
201280_s_at
210757_PM_x_at
210757_x_at
2854443
2854444
2854446
2854447
2854448
2854449
2854453
2854455
2854457
2854458
2854459
2854463
2854464
2854465
2854471
2854472
2854479
2854480
2854483
2854485
2854488
2854489
2854490
2854491
2854492
2854508
45341_at
479_at
51367_at
8111772
A_23_P257871
A_32_P183047
A_33_P3338928
GE59240
GO:0000122
GO:0001650
GO:0001934
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0005925
GO:0006351
GO:0006355
GO:0006629
GO:0006897
GO:0006898
GO:0006915
GO:0007155
GO:0007179
GO:0010718
GO:0010977
GO:0012501
GO:0015031
GO:0016020
GO:0016055
GO:0016192
GO:0023052
GO:0030136
GO:0030154
GO:0030163
GO:0030308
GO:0030335
GO:0030665
GO:0031410
GO:0032091
GO:0032349
GO:0032436
GO:0035026
GO:0035615
GO:0036211
GO:0038024
GO:0043066
GO:0043226
GO:0043231
GO:0045807
GO:0045944
GO:0046332
GO:0048268
GO:0048471
GO:0048545
GO:0048856
GO:0048870
GO:0050680
GO:0050750
GO:0050886
GO:0060090
GO:0060391
GO:0060766
GO:0065003
GO:0070373
GO:0071364
GO:0071560
GO:0072659
GO:0090090
GO:1900026
GO:1902074
GO:1903077
GO:2000096
GO:2000370
GO:2000643
GO:2000860
HMNXSV003046451
Hs.81988.0.S3_3p_at
ILMN_1764228
ILMN_2128428
PH_hs_0027712
TC05002969.hg
TC05003425.hg
U53446_at
g13111753_3p_a_at
g4503250_3p_a_at
Participates
as a member of
DAB2,LDLRAP1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
as a component of
LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
LRP2:DAB2 [plasma membrane] (Homo sapiens)
as an input of
DAB2 binds LRP2 (Homo sapiens)
Other forms of this molecule
DAB2 [lysosomal membrane]
DAB2 [plasma membrane]
Inferred To
Dab2 [cytosol]
(Mus musculus)
Dab2 [cytosol]
(Rattus norvegicus)
DAB2 [cytosol]
(Bos taurus)
DAB2 [cytosol]
(Canis familiaris)
DAB2 [cytosol]
(Gallus gallus)
DAB2 [cytosol]
(Sus scrofa)
dab2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001231800.1
,
NP_001334.2
OpenTargets
ENSG00000153071
GeneCards
P98082
HPA
ENSG00000153071-DAB2
Ensembl
ENSP00000345508
,
ENST00000509337
,
ENST00000320816
,
ENSG00000153071
,
ENSP00000313391
,
ENSP00000439919
,
ENST00000339788
,
ENST00000545653
,
ENSP00000426245
PRO
P98082
Pharos - Targets
P98082
PDB
6OVF
,
6O5O
,
2LSW
HMDB Protein
HMDBP14533
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.573
2
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UM54 MYO6
3
MYO6 [plasma membrane]
(R-HSA-3006691)
MYO6 [lysosomal membrane]
(R-HSA-3006694)
MYO6 [cytosol]
(R-HSA-3006692)
0.543
3
UniProt:Q8N5S1 S2541
0.527
2
UniProt:Q0JRZ9 FCHO2
1
FCHO2 [cytosol]
(R-HSA-8862260)
0.527
3
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.524
20
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
4
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.524
3
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