Reactome | TOR1A [cytosol]

TOR1A [cytosol]

Stable Identifier

R-HSA-8862858

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Torsin-1A, TOR1A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14656 TOR1A

Gene Names

TOR1A, DQ2, DYT1, TA, TORA

Chain

signal peptide:1-20, chain:21-332

Reference Genes

BioGPS Gene:1861 TOR1A

COSMIC (genes):TOR1A TOR1A

CTD Gene:1861 TOR1A

dbSNP Gene:1861 TOR1A

ENSEMBL:ENSG00000136827 TOR1A

HGNC:3098 TOR1A

KEGG Gene (Homo sapiens):1861 TOR1A

Monarch:1861 TOR1A

NCBI Gene:1861 TOR1A

OMIM:605204 TOR1A

UCSC:O14656 TOR1A

Reference Transcript

RefSeq:NM_000113.2 TOR1A

Other Identifiers

0006420390

11720764_a_at

11720765_s_at

11758220_s_at

17099083

1861

202348_3p_s_at

202348_s_at

202349_at

32234_at

3227097

3227099

3227100

3227101

3227102

3227103

3227107

3227108

3227109

3227115

3227116

3227117

3227119

3227120

8164587

A_24_P269687

A_33_P3313889

GE54089

GO:0000166

GO:0000338

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005788

GO:0005829

GO:0005856

GO:0006457

GO:0006464

GO:0006810

GO:0006950

GO:0006979

GO:0006996

GO:0006998

GO:0007010

GO:0007155

GO:0007267

GO:0008021

GO:0008092

GO:0008150

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0016887

GO:0019894

GO:0030054

GO:0030133

GO:0030141

GO:0030154

GO:0030426

GO:0030659

GO:0031175

GO:0031410

GO:0031965

GO:0034504

GO:0040011

GO:0042406

GO:0042802

GO:0042995

GO:0043005

GO:0043167

GO:0043226

GO:0043231

GO:0044319

GO:0045104

GO:0045202

GO:0048489

GO:0048856

GO:0048870

GO:0051082

GO:0051085

GO:0051584

GO:0051787

GO:0061024

GO:0061077

GO:0070062

GO:0071712

GO:0071763

GO:0072321

GO:1900244

GO:2000008

ILMN_1805812

PH_hs_0001697

TC09001654.hg

g12653776_3p_a_at

g12653776_3p_x_at

g4557540_3p_at

Participant Of

hasComponent

TOR1A hexamer [cytosol]

Inferred To

Dmel\CG4880 [cytosol] (Drosophila melanogaster)

tor1a [cytosol] (Xenopus tropicalis)

tor1l2 [cytosol] (Danio rerio)

TOR1A [cytosol] (Bos taurus)

TOR1A [cytosol] (Canis familiaris)

TOR1A [cytosol] (Dictyostelium discoideum)

TOR1A [cytosol] (Gallus gallus)

TOR1A [cytosol] (Sus scrofa)

tor-1 [cytosol] (Caenorhabditis elegans)

Homologues of TOR1A [cytosol] (Caenorhabditis elegans)

Homologues of TOR1A [cytosol] (Danio rerio)

Homologues of TOR1A [cytosol] (Drosophila melanogaster)

tor1 [cytosol] (Danio rerio)

tor1l1 [cytosol] (Danio rerio)

tor-2 [cytosol] (Caenorhabditis elegans)

Tor1a [cytosol] (Mus musculus)

Tor1a [cytosol] (Rattus norvegicus)

Torsin [cytosol] (Drosophila melanogaster)

tor1l3 [cytosol] (Danio rerio)

ooc-5 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000104.1

OpenTargets

ENSG00000136827

HPA

ENSG00000136827-TOR1A

GeneCards

O14656

Ensembl

ENSG00000136827, ENSP00000345719, ENST00000351698

PRO

O14656

Orphanet

15643

PDB

5J1S, 6OIF, 5J1T

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22692 IGFBP4	5	p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038) IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754) IGFBP4 [extracellular region] (R-HSA-381421) IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q96NW7 LRRC7	3	LRRC7 [specific granule lumen] (R-HSA-6799616) LRRC7 [extracellular region] (R-HSA-6799681) LRRC7 [cytosol] (R-HSA-9611351)	0.488	2

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