Reactome | p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]

p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]

Stable Identifier

R-HSA-444290

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho(S218,T356,S360,S377,T570,T730)-Ribosomal protein S6 kinase alpha 2, p-S218,T356,S360,S377,T570,T730-RSK3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15349 RPS6KA2

Gene Names

RPS6KA2, MAPKAPK1C, RSK3

Chain

chain:1-733

Reference Genes

BioGPS Gene:6196 RPS6KA2

COSMIC (genes):RPS6KA2 RPS6KA2

CTD Gene:6196 RPS6KA2

dbSNP Gene:6196 RPS6KA2

ENSEMBL:ENSG00000071242 RPS6KA2

ENSEMBL_homo_sapiens_GENE:ENSG00000071242.12 RPS6KA2

HGNC:10431 RPS6KA2

KEGG Gene (Homo sapiens):6196 RPS6KA2

Monarch:6196 RPS6KA2

NCBI Gene:6196 RPS6KA2

OMIM:601685 RPS6KA2

UCSC:Q15349 RPS6KA2

Reference Transcript

Other Identifiers

11731762_s_at

11731763_s_at

11743831_s_at

11756657_a_at

1557970_PM_s_at

1557970_s_at

204906_PM_at

204906_at

212912_PM_at

212912_at

2984665

2984666

2984667

2984668

2984669

2984670

2984671

2984672

2984673

2984674

2984675

2984677

2984678

2984679

2984680

2984683

2984685

2984695

2984697

2984698

2984703

2984720

2984722

2984730

2984733

2984736

2984743

2984744

2984754

2984759

2984786

2984787

2984810

2984811

2984812

2984813

2984814

2984936

32892_at

33325_at

54736_at

6196

8130739

A_23_P335920

A_33_P3347452

A_33_P3399935

A_33_P3399943

GE82591

GE86143

GO:0000166

GO:0000287

GO:0001556

GO:0002035

GO:0003013

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0006468

GO:0007165

GO:0007268

GO:0007507

GO:0008285

GO:0010628

GO:0010659

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0035556

GO:0036211

GO:0043065

GO:0043226

GO:0045202

GO:0045786

GO:0045835

GO:0046872

GO:0048856

GO:0050877

GO:0050886

GO:0051604

GO:0060047

GO:0070613

GO:0071322

GO:0072687

GO:0106310

GO:0140013

GO:0140096

HMNXSV003031331

Hs.184581.0.A1_3p_at

Hs2.397210.1.S1_3p_s_at

ILMN_1702501

ILMN_1790801

PH_hs_0015556

TC06004057.hg

X85106_at

g12803118_3p_at

Participates

as a member of

p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS6KA2 [nucleoplasm]

p-4S,T356,T570-RPS6KA2 [nucleoplasm]

RPS6KA2 [cytosol]

p-T356,S360,T570-RPS6KA2 [cytosol]

p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]

p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]

Inferred To

phospho-RPS6KA2 [nucleoplasm] (Canis familiaris)

phospho-RPS6KA2 [nucleoplasm] (Gallus gallus)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Bos taurus)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Mus musculus)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Rattus norvegicus)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Sus scrofa)

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 218

Coordinate

218

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 356

Coordinate

356

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 360

Coordinate

360

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 377

Coordinate

377

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 570

Coordinate

570

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 730

Coordinate

730

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001305865.1, NP_066958.2, NP_001305867.1, NP_001305866.1, NP_001006933.2

ZINC - World Drugs

KS6A2_HUMAN

Guide to Pharmacology - Targets

1529

OpenTargets

ENSG00000071242

ZINC - FDA approved

KS6A2_HUMAN

ZINC - Substances

KS6A2_HUMAN

ZINC - Biogenic

KS6A2_HUMAN

ZINC target

Q15349

PRO

Q15349

ZINC - Investigational

KS6A2_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000071242-RPS6KA2

GeneCards

Q15349

Ensembl

ENSP00000265678, ENST00000265678, ENSG00000071242, ENSP00000427015, ENST00000503859

Pharos - Targets

Q15349

ZINC - Predictions - Purchasable

KS6A2_HUMAN

HMDB Protein

HMDBP01159

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.914	12
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.769	9
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.725	5
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.706	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q12849 GRSF1	2	GRSF1 [mitochondrial matrix] (R-HSA-9837006) GRSF1 [cytosol] (R-HSA-192689)	0.527	2

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