Reactome | PRKCD(1-329) [azurophil granule lumen]

PRKCD(1-329) [azurophil granule lumen]

Stable Identifier

R-HSA-6799219

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

PKC-delta (fragment 1-329)

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q05655 PRKCD

Gene Names

PRKCD, PKCD

Chain

chain:1-676, chain:1-329, chain:330-676

Reference Genes

BioGPS Gene:5580 PRKCD

COSMIC (genes):PRKCD PRKCD

CTD Gene:5580 PRKCD

dbSNP Gene:5580 PRKCD

ENSEMBL:ENSG00000163932 PRKCD

ENSEMBL_homo_sapiens_GENE:ENSG00000163932.16 PRKCD

HGNC:9399 PRKCD

KEGG Gene (Homo sapiens):5580 PRKCD

Monarch:5580 PRKCD

NCBI Gene:5580 PRKCD

OMIM:176977 PRKCD

UCSC:Q05655 PRKCD

Reference Transcript

Other Identifiers

11727841_a_at

11736573_a_at

16941781

1810_s_at

202545_PM_at

202545_at

2624292

2624294

2624303

2624304

2624305

2624306

2624307

2624308

2624310

2624311

2624313

2624314

2624316

2624318

2624319

2624320

2624323

2624327

2624329

2624330

2624331

2624333

2624334

2624335

32046_at

5580

8080487

A_14_P104518

A_14_P138877

A_23_P144054

D10495_at

GE57042

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004699

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005773

GO:0005783

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006629

GO:0006886

GO:0006913

GO:0006915

GO:0006954

GO:0006974

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0008047

GO:0008631

GO:0010469

GO:0012501

GO:0012505

GO:0016020

GO:0016064

GO:0016071

GO:0016192

GO:0016301

GO:0016310

GO:0016363

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0019901

GO:0023021

GO:0023052

GO:0030837

GO:0031410

GO:0032079

GO:0032091

GO:0032147

GO:0032930

GO:0032956

GO:0034351

GO:0034644

GO:0035307

GO:0035556

GO:0035578

GO:0036019

GO:0036211

GO:0038096

GO:0042060

GO:0042100

GO:0042119

GO:0042307

GO:0042742

GO:0043226

GO:0043407

GO:0043488

GO:0043560

GO:0043687

GO:0046627

GO:0046872

GO:0048471

GO:0048870

GO:0050728

GO:0050732

GO:0050821

GO:0050896

GO:0051490

GO:0060326

GO:0061024

GO:0065003

GO:0070062

GO:0070301

GO:0071447

GO:0080090

GO:0090331

GO:0090398

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:1900163

GO:1901135

GO:1904385

GO:2000303

GO:2000304

GO:2000753

GO:2000755

GO:2001235

HMNXSV003051624

ILMN_1682813

ILMN_1801105

PH_hs_0009356

TC03000348.hg

TC03002349.hg

g5453969_3p_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

PRKCD(1-676) [nucleoplasm]

PRKCD(330-676) [extracellular region]

PRKCD(1-329) [extracellular region]

PRKCD(330-676) [azurophil granule lumen]

p-T507-PRKCD [cytosol]

p-T507,S645,S664-PRKCD [cytosol]

active p-T507,S645,S664-PRKCD [plasma membrane]

p-T507,S645,S664-PRKCD(1-676) [plasma membrane]

PRKCD(330-676) [cytosol]

PRKCD(1-329) [cytosol]

PRKCD [cytosol]

Inferred To

Homologues of PRKCD(1-329) [azurophil granule lumen] (Dictyostelium discoideum)

Homologues of PRKCD(1-329) [azurophil granule lumen] (Schizosaccharomyces pombe)

PRKCD [azurophil granule lumen] (Canis familiaris)

PRKCD [azurophil granule lumen] (Gallus gallus)

PRKCD(1-329) [azurophil granule lumen] (Bos taurus)

PRKCD(1-329) [azurophil granule lumen] (Caenorhabditis elegans)

PRKCD(1-329) [azurophil granule lumen] (Danio rerio)

PRKCD(1-329) [azurophil granule lumen] (Dictyostelium discoideum)

PRKCD(1-329) [azurophil granule lumen] (Drosophila melanogaster)

PRKCD(1-329) [azurophil granule lumen] (Mus musculus)

PRKCD(1-329) [azurophil granule lumen] (Rattus norvegicus)

PRKCD(1-329) [azurophil granule lumen] (Saccharomyces cerevisiae)

PRKCD(1-329) [azurophil granule lumen] (Schizosaccharomyces pombe)

PRKCD(1-329) [azurophil granule lumen] (Sus scrofa)

PRKCD(1-329) [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001303256.1, XP_016862344.1, XP_016862345.1, NP_006245.2, NP_997704.1, XP_006713322.1

ZINC - World Drugs

KPCD_HUMAN

Guide to Pharmacology - Targets

1485

OpenTargets

ENSG00000163932

ZINC - FDA approved

KPCD_HUMAN

ZINC - Substances

KPCD_HUMAN

ZINC - Biogenic

KPCD_HUMAN

ZINC target

Q05655

PRO

Q05655

PDB

1YRK, 2YUU

ZINC - Investigational

KPCD_HUMAN

ZINC - Metabolites

KPCD_HUMAN

IntEnz

2.7.10.2, 2.7.11.13

HPA

ENSG00000163932-PRKCD

GeneCards

Q05655

Ensembl

ENST00000652449, ENSG00000163932, ENST00000330452, ENSP00000331602, ENST00000654719, ENST00000394729, ENSP00000498623, ENST00000650739, ENSP00000378217, ENSP00000498400, ENSP00000499558

Pharos - Targets

Q05655

ZINC - Predictions - Purchasable

KPCD_HUMAN

Orphanet

22033

HMDB Protein

HMDBP01847

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.737	5
UniProt:P24001-2 IL32			0.728	7
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.679	10
UniProt:Q9H5V8 CDCP1			0.675	7
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.619	7
UniProt:P17677 GAP43	2	PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482) GAP43 [plasma membrane] (R-HSA-452888)	0.602	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.602	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:P19878 NCF2	2	p-T233-NCF2 [phagolysosome] (R-HSA-1996211) NCF2 [cytosol] (R-HSA-1222600)	0.544	3
UniProt:Q04759 PRKCQ	9	PRKCQ [photoreceptor disc membrane] (R-HSA-2648997) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ(1-354) [cytosol] (R-HSA-212526) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ [cytosol] (R-HSA-58216) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [plasma membrane] (R-HSA-202346) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152)	0.527	2
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.527	2
UniProt:P05771 PRKCB	5	PRKCB [plasma membrane] (R-HSA-156467) PRKCB [cytosol] (R-HSA-58198) p-T500-PRKCB [cytosol] (R-HSA-5218728) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294)	0.527	2
UniProt:P57078 RIPK4			0.527	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.527	3
UniProt:C6GKH1 C6GKH1			0.463	3
UniProt:Q12816 TROP			0.463	2

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