10xCbxE-F2(25-622) [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-159800
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
pro-prothrombin (factor II)
Icon
10xCbxE-F2(25-622) [endoplasmic reticulum lumen] icon
10xCbxE-F2(25-622) [endoplasmic reticulum lumen] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
873923 Primary structure of human prethrombin 2 and alpha-thrombin

Butkowski, RJ, Elion, J, Downing, MR, Mann, KG

J Biol Chem 1977
2825773 Nucleotide sequence of the gene for human prothrombin

Degen, SJ, Davie, EW

Biochemistry 1987
266717 Amino acid sequence of human prothrombin fragments 1 and 2

Walz, DA, Hewett-Emmett, D, Seegers, WH

Proc Natl Acad Sci U S A 1977
External Reference Information
External Reference
UniProt:P00734 F2
Gene Names
F2
Chain
signal peptide:1-24, propeptide:25-43, chain:44-622, peptide:44-198, peptide:199-327, chain:315-363, chain:364-622
Reference Genes
BioGPS Gene:2147 F2
COSMIC (genes):F2 F2
CTD Gene:2147 F2
dbSNP Gene:2147 F2
ENSEMBL:ENSG00000180210 F2
HGNC:3535 F2
KEGG:hsa:2147 F2
Monarch:2147 F2
NCBI Entrez Gene:2147 F2
OMIM:176930 F2
UCSC:P00734 F2
Reference Transcript
Other Identifiers
11723003_a_at
11723004_x_at
11750896_a_at
16724411
205754_PM_at
205754_at
2147
3329476
3329477
3329478
3329479
3329480
3329481
3329482
3329483
3329484
3329485
3329486
3329487
3329488
3329489
3329490
3329491
3329492
3329493
3329494
3329499
3329501
3329502
3329503
37202_at
7939706
A_14_P137295
A_24_P85574
GE58225
GO:0001530
GO:0002376
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0005886
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0007599
GO:0008083
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0010544
GO:0016787
GO:0030168
GO:0030193
GO:0030194
GO:0030195
GO:0030307
GO:0030312
GO:0031012
GO:0032024
GO:0032967
GO:0042730
GO:0045861
GO:0046427
GO:0048018
GO:0048712
GO:0050878
GO:0051281
GO:0051480
GO:0051604
GO:0051838
GO:0051897
GO:0051918
GO:0061844
GO:0070053
GO:0070062
GO:0070493
GO:0070945
GO:0072378
GO:0072562
GO:0098542
GO:0098772
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
HMNXSV003023107
M17262_at
PH_hs_0004418
TC11000401.hg
TC11002660.hg
g5922005_3p_at
Participates
as an input of
as an output of
Other forms of this molecule
thrombin light chain [extracellular region]
thrombin heavy chain [extracellular region]
10xCbxE-F2(44-622) [extracellular region]
10xCbxE-F2(44-327) [extracellular region]
thrombin light chain [plasma membrane]
thrombin heavy chain [plasma membrane]
F2(25-622) [endoplasmic reticulum lumen]
10xCbxE-F2(25-622) [Golgi lumen]
10xCbxE-F2(44-622) [Golgi lumen]
prothrombin (factor II) propeptide [Golgi lumen]
Inferred To
10xCbxE-F2(25-622) [endoplasmic reticulum lumen] (Gallus gallus)
F2 [endoplasmic reticulum lumen] (Bos taurus)
F2 [endoplasmic reticulum lumen] (Canis familiaris)
F2 [endoplasmic reticulum lumen] (Mus musculus)
F2 [endoplasmic reticulum lumen] (Rattus norvegicus)
F2 [endoplasmic reticulum lumen] (Sus scrofa)
f2 [endoplasmic reticulum lumen] (Xenopus tropicalis)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 75
Coordinate
75
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 72
Coordinate
72
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 69
Coordinate
69
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 68
Coordinate
68
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 63
Coordinate
63
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 62
Coordinate
62
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 59
Coordinate
59
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 57
Coordinate
57
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 50
Coordinate
50
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 49
Coordinate
49
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
5EW2, 1MUE, 2AFQ, 1D3D, 2JH6, 1UVS, 3SI4, 3DD2, 2ZC9, 1BA8, 3TU7, 1UMA, 5Z5W, 2C8W, 1AHT, 1EOL, 3DA9, 3QTV, 1DX5, 1C5L, 1LHC, 2HGT, 1A3B, 3HAT, 1NZQ, 2CF9, 2H9T, 1CA8, 1H8D, 2V3O, 3HKJ, 3UTU, 5GIM, 2JH5, 4BOH, 1DIT, 5JDU, 3DHK, 3U69, 2C8X, 1A46, 1A3E, 5CMX, 1YPM, 5AF9, 3PMH, 5E8E, 4UFD, 5NHU, 1NRR, 1C5N, 3HTC, 2ZDA, 1LHD, 3P6Z, 1XMN, 4NZQ, 4DIH, 2ZHW, 4RKO, 3EGK, 1BMM, 1XM1, 4HZH, 3BV9, 1C1W, 2C8Y, 1D9I, 4BAQ, 1NT1, 1G32, 3RML, 3RM2, 1ZGI, 1C5O, 2ZNK, 1TA6, 1QBV, 3BEI, 3RMN, 1WBG, 4LZ1, 8KME, 3SI3, 3GIS, 3QLP, 4UD9, 5A2M, 5TO3, 2C8Z, 1B5G, 1AI8, 1G30, 2ANK, 1C4U, 1A61, 4DY7, 4HFP, 1GHV, 1SG8, 3RMO, 1SHH, 3U8R, 3B9F, 4LXB, 1YPE, 2R2M, 1DWC, 2B5T, 4E7R, 3QDZ, 3K65, 1YPJ, 4I7Y, 1O0D, 2ZFP, 6C2W, 1Z8I, 3BIV, 1B7X, 4H6S, 1E0F, 3GIC, 5JFD, 2ZHE, 1EB1, 2GP9, 5GDS, 1VR1, 2JH0, 4O03, 2OD3, 2UUK, 3VXF, 1A4W, 4E06, 3JZ1, 9CMO, 5AFY, 3SHA, 8RTN, 2ZFQ, 2ZDV, 1NRP, 1K22, 1QHR, 1HAG, 1THS, 3P17, 1AE8, 5EW1, 1DOJ, 1TQ0, 1O2G, 2HNT, 4HTC, 5MLS, 3QGN, 4BAH, 2UUJ, 3VXE, 6EO9, 1YPL, 4E05, 1NY2, 1MU8, 1SB1, 2V3H, 1Z8J, 1NRQ, 1IHS, 2A2X, 1PPB, 9CTH, 1HAH, 4THN, 3U8O, 1D4P, 1HGT, 3SV2, 2CF8, 3QX5, 1NRS, 1YPG, 7KME, 5EDK, 2A0Q, 4RN6, 6EO8, 3RMM, 1YPK, 1HBT, 1MU6, 2ZG0, 1G37, 4RKJ, 3BIU, 1IHT, 1HLT, 1HAI, 6BJR, 1THP, 4CH2, 3QTO, 4UFF, 1KTS, 1TBZ, 3D49, 1NM6, 1C1V, 2ZGB, 1RD3, 2PGQ, 1T4V, 1GJ4, 1BB0, 1WAY, 2ZFF, 8BWW, 1EOJ, 3LU9, 3RLY, 1LHF, 5JZY, 1NRN, 2A45, 1TA2, 4LOY, 4UDW, 2ZF0, 1O5G, 2PW8, 4UFG, 1OYT, 1ZRB, 1C1U, 4BAK, 4YES, 2UUF, 1HXF, 1ABJ, 4UEH, 3UWJ, 6EO7, 3U9A, 3NXP, 3RLW, 2BDY, 3F68, 3B23, 6V5T, 1THR, 2ZHF, 9CLS, 3U8T, 1JOU, 1VZQ, 1TQ7, 1RIW, 1ABI, 2BXU, 3PO1, 5MM6, 3DUX, 1AWF, 5L6N, 1TMB, 1LHG, 3R3G, 5Z5X, 3SHC, 1SR5, 1K21, 1SFQ, 3SQH, 1W7G, 4MLF, 2BVX, 4UFE, 3SQE, 1KTT, 1TB6, 1DWB, 3C27, 1H8I, 1BHX, 1QUR, 2BXT, 1QJ1, 3EE0, 1GJ5, 3JZ2, 5DO4, 1NRO, 2ZFR, 2PKS, 2GDE, 4H6T, 4UE7, 1OOK, 3BEF, 2BVR, 3S7H, 4LZ4, 9CLN, 2FEQ, 1NU7, 3BF6, 1JWT, 1D3P, 4BAN, 1SL3, 4AYY, 3LDX, 1QJ7, 1D6W, 3RM0, 1AFE, 1GHX, 1A5G, 4DII, 1FPH, 3QWC, 2BVS, 3P70, 3S7K, 2PGB, 5MJT, 4AZ2, 1NU9, 1AIX, 2HPP, 1A2C, 3EQ0, 1BMN, 2C93, 3C1K, 4BAO, 2ZGX, 7TPP, 1HUT, 3E6P, 2ANM, 1ZGV, 1QJ6, 2C90, 5AHG, 1C4V, 5AFZ, 1FPC, 2HWL, 1GHW, 1JMO, 1TWX, 2ZO3, 2ZHQ, 3DT0, 1DE7, 4CH8, 1AWH, 1D3T, 5EDM, 3T5F, 4AYV, 1AY6, 1TMU, 1AD8, 1HAO, 1HXE, 3U98, 6EO6, 1T4U, 1Z71, 1NO9, 1C4Y, 1DWD, 8UF7, 2CN0, 1BTH, 1P8V, 2ZI2, 4AX9, 2FES, 1HDT, 1BCU, 1DM4, 2HPQ, 1D3Q, 4DT7, 4BAM, 1TMT, 1HAP, 1SGI, 1TOM, 1MH0, 2THF, 1LHE, 2ZIQ, 1DWE, 1GHY
ZINC - Investigational
ZINC - Metabolites
HPA
GeneCards
F2
Pharos - Targets
Orphanet
F2
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (5)
Cite Us!