MAP2K2 N126D [cytosol]

Stable Identifier
R-HSA-9652079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2
MAP2K2 N126D [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24265153 The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

Van Allen, EM, Wagle, N, Sucker, A, Treacy, DJ, Johannessen, CM, Goetz, EM, Place, CS, Taylor-Weiner, A, Whittaker, S, Kryukov, GV, Hodis, E, Rosenberg, M, McKenna, A, Cibulskis, K, Farlow, D, Zimmer, L, Hillen, U, Gutzmer, R, Goldinger, SM, Ugurel, S, Gogas, HJ, Egberts, F, Berking, C, Trefzer, U, Loquai, C, Weide, B, Hassel, JC, Gabriel, SB, Carter, SL, Getz, G, Garraway, LA, Schadendorf, D, Dermatologic Cooperative Oncology Group of Germany (DeCOG), -

Cancer Discov 2014
External Reference Information
External Reference
Gene Names
MAP2K2, MEK2, MKK2, PRKMK2
Chain
chain:1-400
Reference Transcript
Other Identifiers
0003710047
1131_at
11716318_x_at
202424_at
213490_s_at
3023305
3023308
3023309
3023310
3846639
3846640
3846643
3846645
3846646
3846650
3846652
3846653
3846654
3846659
3846660
3846663
3846664
3846665
3846666
5605
8032761
A_23_P208835
GE57609
GO:0000165
GO:0000166
GO:0000187
GO:0000278
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005777
GO:0005778
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005911
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007346
GO:0008150
GO:0009058
GO:0009898
GO:0010629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0023014
GO:0030165
GO:0030234
GO:0030674
GO:0031098
GO:0031410
GO:0032147
GO:0032872
GO:0034641
GO:0036289
GO:0043167
GO:0043226
GO:0043539
GO:0045893
GO:0046872
GO:0048471
GO:0070371
GO:0071902
GO:0090170
GO:0097110
GO:1903800
GO:2000641
Hs.72241.1.S1_3p_a_at
ILMN_1657968
ILMN_1752423
L11285_at
PH_hs_0029886
TC19001058.hg
g13489053_3p_at
g13489053_3p_x_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-asparagine 126 replaced with L-aspartic acid
Coordinate
126
PsiMod
A protein modification that effectively removes or replaces an L-asparagine.
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
Disease
Name Identifier Synonyms
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
COSMIC
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (14)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P10398 ARAF  4 0.839 7
 UniProt:P15056 BRAF  68 0.802 9
 UniProt:P04049 RAF1  54 0.745 5
 UniProt:Q8IVT5 KSR1  5 0.659 8
 UniProt:Q96II5 Q96II5      0.601 4
 UniProt:P61978-2 HNRNPK      0.556 3
 UniProt:O95273 CCDB1      0.556 3
 UniProt:P00540 MOS      0.556 3
 UniProt:Q92905 COPS5  2 0.553 2
 UniProt:Q12959 DLG1  4 0.543 10
 UniProt:P11142 HSPA8  10 0.527 3
 UniProt:P68366 TUBA4A  9 0.527 3
 UniProt:P31946 YWHAB  1 0.527 3
 UniProt:Q61097  5 0.508 2
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