Reactome | MAP2K2 N126D [cytosol]

MAP2K2 N126D [cytosol]

Stable Identifier

R-HSA-9652079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MAP2K mutants (Homo sapiens)
      - MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
        
        MAP2K1 and MAP2K2 mutants [cytosol] (Homo sapiens)
        
        MAP2K2 N126D dimer [cytosol] (Homo sapiens)
        
        MAP2K2 N126D [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
24265153	The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma Van Allen, EM, Wagle, N, Sucker, A, Treacy, DJ, Johannessen, CM, Goetz, EM, Place, CS, Taylor-Weiner, A, Whittaker, S, Kryukov, GV, Hodis, E, Rosenberg, M, McKenna, A, Cibulskis, K, Farlow, D, Zimmer, L, Hillen, U, Gutzmer, R, Goldinger, SM, Ugurel, S, Gogas, HJ, Egberts, F, Berking, C, Trefzer, U, Loquai, C, Weide, B, Hassel, JC, Gabriel, SB, Carter, SL, Getz, G, Garraway, LA, Schadendorf, D, Dermatologic Cooperative Oncology Group of Germany (DeCOG), -	Cancer Discov	2014

External Reference Information

External Reference

UniProt:P36507 MAP2K2

Gene Names

MAP2K2, MEK2, MKK2, PRKMK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:5605 MAP2K2

COSMIC (genes):MAP2K2 MAP2K2

CTD Gene:5605 MAP2K2

dbSNP Gene:5605 MAP2K2

ENSEMBL:ENSG00000126934 MAP2K2

HGNC:6842 MAP2K2

KEGG:hsa:5605 MAP2K2

Monarch:5605 MAP2K2

NCBI Gene:5605 MAP2K2

OMIM:601263 MAP2K2

UCSC:P36507 MAP2K2

Reference Transcript

RefSeq:NM_030662.4 MAP2K2

Other Identifiers

1131_at

11716318_x_at

16867240

202424_PM_at

202424_at

213490_PM_s_at

213490_s_at

3023305

3023308

3023309

3023310

3846639

3846640

3846643

3846644

3846645

3846646

3846647

3846648

3846649

3846650

3846651

3846652

3846653

3846654

3846655

3846656

3846659

3846660

3846663

3846664

3846665

3846666

5605

8032761

A_23_P208835

GE57609

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005078

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005778

GO:0005783

GO:0005794

GO:0005829

GO:0005874

GO:0005911

GO:0005925

GO:0006355

GO:0006468

GO:0007507

GO:0009898

GO:0010628

GO:0014044

GO:0016020

GO:0016301

GO:0016740

GO:0030165

GO:0030878

GO:0032872

GO:0036289

GO:0038133

GO:0042552

GO:0043226

GO:0043539

GO:0045893

GO:0046872

GO:0048009

GO:0048471

GO:0048538

GO:0048679

GO:0048856

GO:0050772

GO:0060090

GO:0060324

GO:0060425

GO:0060440

GO:0060502

GO:0070371

GO:0071902

GO:0090170

GO:0097110

GO:0098772

GO:0106310

GO:0140096

GO:2000147

GO:2000641

HMNXSV003002037

Hs.72241.1.S1_3p_a_at

ILMN_1657968

L11285_at

PH_hs_0029886

TC19001058.hg

g13489053_3p_at

g13489053_3p_x_at

Participates

as a component of

MAP2K2 N126D dimer [cytosol] (Homo sapiens)

Other forms of this molecule

p-S222,S226-MAP2K2 [cytosol]

MAP2K2 [cytosol]

p-S,T-MAP2K2 [cytosol]

MAP2K2 L46F [cytosol]

MAP2K2 F57C [cytosol]

MAP2K2 Y134C [cytosol]

MAP2K2 V35M [cytosol]

MAP2K2 P128Q [cytosol]

MAP2K2 C125S [cytosol]

MAP2K2(11-400) [cytosol]

MAP2K2(1-10) [cytosol]

Modified Residues

Name

L-asparagine 126 replaced with L-aspartic acid

Coordinate

126

PsiMod

L-aspartic acid residue [MOD:00013]

A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.

L-asparagine removal [MOD:01633]

A protein modification that effectively removes or replaces an L-asparagine.

Disease

Name	Identifier	Synonyms
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma

Cross References

RefSeq

NP_109587.1

ZINC - World Drugs

MP2K2_HUMAN

Guide to Pharmacology - Targets

2063

OpenTargets

ENSG00000126934

ENSEMBL

ENSG00000126934, ENSP00000262948, ENST00000262948

Mondo

0005105

ZINC - FDA approved

MP2K2_HUMAN

ZINC - Substances

MP2K2_HUMAN

ZINC - Biogenic

MP2K2_HUMAN

ZINC target

P36507

PRO

P36507

GlyGen

P36507

PDB

1S9I, 4H3Q

ZINC - Investigational

MP2K2_HUMAN

COSMIC

COSV53566961

GeneCards

MAP2K2

HPA

ENSG00000126934-MAP2K2

Pharos - Targets

P36507

Orphanet

MAP2K2

ZINC - Predictions - Purchasable

MP2K2_HUMAN

HMDB Protein

HMDBP09528

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.91	10
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.894	13
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.85	7
UniProt:Q8IVT5 KSR1	5	p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311 KSR1 [cytosol] (R-HSA-5672652) KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654)	0.798	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.725	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	6
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.676	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.671	5
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.643	5
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.643	5
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.643	9
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.643	4
UniProt:Q96II5 Q96II5			0.601	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q92905 COPS5	3	CSN5 [cytosol] (R-HSA-9929354) COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.553	2
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q58FG1 HS904			0.527	3
UniProt:Q58FG0 HS905			0.527	3
UniProt:Q58FF6 H90B4			0.527	3
UniProt:P04439 HLA-A	9	HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.527	3
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.527	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.527	3
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	3
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	3
UniProt:Q61097	5	phospho-Ksr1 [cytosol] (R-MMU-5672654) Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.508	2
UniProt:P06929 VE6			0.488	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.483	2

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