Reactome | CLPP [mitochondrial matrix]

CLPP [mitochondrial matrix]

Stable Identifier

R-HSA-9838002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP-dependent Clp protease proteolytic subunit, mitochondrial ecNumber evidence="5 6 9"3.4.21.92/ecNumber, CLPP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16740 CLPP

Gene Names

CLPP

Chain

transit peptide:1-56, chain:57-277

Reference Genes

BioGPS Gene:8192 CLPP

COSMIC (genes):CLPP CLPP

CTD Gene:8192 CLPP

dbSNP Gene:8192 CLPP

ENSEMBL:ENSG00000125656 CLPP

HGNC:2084 CLPP

Monarch:8192 CLPP

NCBI Gene:8192 CLPP

OMIM:601119 CLPP

UCSC:Q16740 CLPP

Reference Transcript

RefSeq:NM_006012.2 CLPP

Other Identifiers

11717588_at

16857429

202799_PM_at

202799_at

2576107

32528_at

3818378

3818379

3818380

3818381

3818382

3818383

3818384

3818385

3818386

3818387

3818388

3818389

3818390

3818391

3818392

3818394

8025028

8192

A_23_P4754

GE60424

GO:0003824

GO:0004175

GO:0004176

GO:0004252

GO:0005515

GO:0005739

GO:0005759

GO:0006508

GO:0006515

GO:0008233

GO:0008236

GO:0009368

GO:0016787

GO:0030163

GO:0033619

GO:0035694

GO:0042802

GO:0043226

GO:0051117

GO:0051603

GO:0140096

GO:0140657

HMNXSV003053106

ILMN_1725705

PH_hs_0023770

TC19000112.hg

TC19001953.hg

Z50853_at

g5174418_3p_at

Participates

as a component of

CLPXP [mitochondrial matrix] (Homo sapiens)

Inferred To

clpp [mitochondrial matrix] (Xenopus tropicalis)

Clpp [mitochondrial matrix] (Mus musculus)

Clpp [mitochondrial matrix] (Rattus norvegicus)

CLPP [mitochondrial matrix] (Bos taurus)

CLPP [mitochondrial matrix] (Canis familiaris)

CLPP [mitochondrial matrix] (Sus scrofa)

clpp-1 [mitochondrial matrix] (Caenorhabditis elegans)

ClpP [mitochondrial matrix] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

3273

ENSEMBL

ENST00000245816, ENSP00000245816

OpenTargets

ENSG00000125656

HPA

ENSG00000125656-CLPP

PRO

Q16740

Pharos - Targets

Q16740

HMDB Protein

HMDBP08707

PDB

7UVU, 7UVM, 7UW0, 8YLB, 6H23, 6DL7, 6BBA, 8I7X, 8HGK, 7UVN, 7UVR, 7WH5, 7VP9, 1TG6

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3

Cite Us!