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XylS-SDC1 [Golgi lumen]
Stable Identifier
R-HSA-2064146
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
xylosyl-SDC1, syndecan 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B4GALT7 causes EDS, progeroid type (Homo sapiens)
Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC1 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC1 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC1 [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC1 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC1 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18827 SDC1
Gene Names
SDC1, SDC
Chain
signal peptide:1-22, chain:23-310
Reference Genes
BioGPS Gene:6382 SDC1
COSMIC (genes):SDC1 SDC1
CTD Gene:6382 SDC1
dbSNP Gene:6382 SDC1
ENSEMBL:ENSG00000115884 SDC1
ENSEMBL_homo_sapiens_GENE:ENSG00000115884 SDC1
HGNC:10658 SDC1
KEGG Gene (Homo sapiens):6382 SDC1
Monarch:6382 SDC1
NCBI Gene:6382 SDC1
OMIM:186355 SDC1
UCSC:P18827 SDC1
Reference Transcript
RefSeq:NM_001006946.1 SDC1
RefSeq:NM_002997.4 SDC1
Other Identifiers
0000110377
11716577_s_at
11752754_s_at
11758139_s_at
16894911
201286_at
201287_s_at
2424
2542796
2542797
2542798
2542799
2542800
2542801
2542802
2542812
2542813
2542814
2542815
38127_at
4GVC
4GVD
6185
6382
6EJE
8050557
A_23_P16944
A_24_P97129
AAA60605
AAH08765
AAX93151
AC104792
AJ551176
BC008765
CAA42851
CAA88235
CAB002424
CAD80245
CCDS1697
CH471053
E9PHH3
EAX00828
EAX00829
EAX00830
EAX00831
ENSG00000115884
ENSP00000254351
ENSP00000370542
ENST00000254351
ENST00000381150
EntrezGene:6382
g4506858_3p_s_at
GE60412
GO:0000003
GO:0001523
GO:0001657
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0005887
GO:0006024
GO:0006027
GO:0006629
GO:0006810
GO:0006950
GO:0006954
GO:0007165
GO:0007267
GO:0008022
GO:0008150
GO:0009056
GO:0009058
GO:0009636
GO:0009897
GO:0009986
GO:0010033
GO:0016020
GO:0016021
GO:0016192
GO:0019221
GO:0022607
GO:0030154
GO:0032991
GO:0040011
GO:0042060
GO:0042476
GO:0042542
GO:0042802
GO:0043202
GO:0043226
GO:0048627
GO:0048856
GO:0048870
GO:0050900
GO:0051384
GO:0051591
GO:0051592
GO:0055002
GO:0060009
GO:0060070
GO:0070062
GO:1903543
GO:1903553
H7C1K4
HGNC:10658
HPA006185
Hs.82109.0.S2_3p_at
ILMN_1735304
ILMN_1800038
ILMN_1815308
IPR001050
IPR003585
IPR027789
IPR030479
IPR031190
J05392
MIM:186355
NM_001006946
NM_002997
NP_001006947
NP_002988
PF01034
PH_hs_0004693
SDC1
SDC1-201
SDC1-202
SM00294
TC02001619.hg
uc002rdo.2
uc002rdp.2
UPI000013CE2D
X60306
XM_005262620
XM_005262621
XM_005262622
XP_005262677
XP_005262678
XP_005262679
Z48199
Z48199_at
Participant Of
hasMember
xylosyl-core proteins [Golgi lumen]
Other forms of this molecule
SDC1 [plasma membrane]
Heparan-SDC1 [Golgi lumen]
Heparan(1)-SDC1 [Golgi lumen]
Heparan(2)-SDC1 [Golgi lumen]
Heparan(3)-SDC1 [Golgi lumen]
Heparan(4)-SDC1 [Golgi lumen]
HS(5)-SDC1 [plasma membrane]
HS(3)-SDC1 [plasma membrane]
HS(1)-SDC1 [plasma membrane]
HS(2)-SDC1 [plasma membrane]
HS(4)-SDC1 [plasma membrane]
HS(1)-SDC1 [Golgi lumen]
Gal-Gal-Xyl-SDC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]
Gal-Xyl-SDC1 [Golgi lumen]
SDC1 [Golgi lumen]
HS(6)-SDC1 [lysosomal lumen]
SDC1 [lysosomal lumen]
HS(6)-SDC1 [plasma membrane]
HS(5)-SDC1 [Golgi lumen]
HS(4)-SDC1 [Golgi lumen]
HS(2)-SDC1 [Golgi lumen]
HS(3)-SDC1 [Golgi lumen]
HS(6)-SDC1 [Golgi lumen]
Inferred To
XylS-SDC1 [Golgi lumen] (Bos taurus)
XylS-SDC1 [Golgi lumen] (Caenorhabditis elegans)
XylS-SDC1 [Golgi lumen] (Canis familiaris)
XylS-SDC1 [Golgi lumen] (Drosophila melanogaster)
XylS-SDC1 [Golgi lumen] (Gallus gallus)
XylS-SDC1 [Golgi lumen] (Mus musculus)
XylS-SDC1 [Golgi lumen] (Rattus norvegicus)
XylS-SDC1 [Golgi lumen] (Sus scrofa)
XylS-SDC1 [Golgi lumen] (Taeniopygia guttata)
XylS-SDC1 [Golgi lumen] (Xenopus tropicalis)
Modified Residues
Name
O-xylosyl-L-serine at unknown position
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001006947.1
,
NP_002988.3
OpenTargets
ENSG00000115884
GeneCards
P18827
DOCK Blaster
4GVC
,
4GVD
PRO
P18827
HMDB Protein
HMDBP02143
PDB
6EJE
,
4GVD
,
4GVC
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13009 TIAM1
2
TIAM1 [cytosol]
(R-HSA-195013)
p-Y829-TIAM1 [cytosol]
(R-HSA-3928461)
0.655
5
UniProt:P18827 SDC1
25
Heparan-SDC1 [Golgi lumen]
(R-HSA-2076561)
SDC1 [plasma membrane]
(R-HSA-174758)
Heparan(1)-SDC1 [Golgi lumen]
(R-HSA-2076349)
Heparan(2)-SDC1 [Golgi lumen]
(R-HSA-2076558)
Heparan(3)-SDC1 [Golgi lumen]
(R-HSA-2076314)
Heparan(4)-SDC1 [Golgi lumen]
(R-HSA-2076339)
HS(5)-SDC1 [plasma membrane]
(R-HSA-2076626)
HS(3)-SDC1 [plasma membrane]
(R-HSA-2076691)
HS(1)-SDC1 [plasma membrane]
(R-HSA-2076672)
HS(2)-SDC1 [plasma membrane]
(R-HSA-2076666)
HS(4)-SDC1 [plasma membrane]
(R-HSA-2076693)
HS(1)-SDC1 [Golgi lumen]
(R-HSA-2076321)
Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064247)
GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064082)
Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064148)
XylS-SDC1 [Golgi lumen]
(R-HSA-2064146)
SDC1 [Golgi lumen]
(R-HSA-2054105)
HS(6)-SDC1 [lysosomal lumen]
(R-HSA-2090082)
SDC1 [lysosomal lumen]
(R-HSA-2090025)
HS(6)-SDC1 [plasma membrane]
(R-HSA-2076652)
HS(5)-SDC1 [Golgi lumen]
(R-HSA-2076290)
HS(4)-SDC1 [Golgi lumen]
(R-HSA-2076593)
HS(2)-SDC1 [Golgi lumen]
(R-HSA-2076309)
HS(3)-SDC1 [Golgi lumen]
(R-HSA-2076444)
HS(6)-SDC1 [Golgi lumen]
(R-HSA-2076520)
0.542
2
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