Reactome | p-S28-PPP2R5A [cytosol]

p-S28-PPP2R5A [cytosol]

Stable Identifier

R-HSA-9836658

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A- 56 kDa regulatory subunit, alpha isoform

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        p-PKR dimer phosphorylates PPP2R5A (Homo sapiens)
        
        Activated PPP2R5A-specific PP2A [cytosol] (Homo sapiens)
        
        p-S28-PPP2R5A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15172 PPP2R5A

Gene Names

PPP2R5A

Chain

initiator methionine:1, chain:2-486

Reference Genes

BioGPS Gene:5525 PPP2R5A

COSMIC (genes):PPP2R5A PPP2R5A

CTD Gene:5525 PPP2R5A

dbSNP Gene:5525 PPP2R5A

ENSEMBL:ENSG00000066027 PPP2R5A

HGNC:9309 PPP2R5A

KEGG:hsa:5525 PPP2R5A

Monarch:5525 PPP2R5A

NCBI Gene:5525 PPP2R5A

OMIM:601643 PPP2R5A

UCSC:Q15172 PPP2R5A

Reference Transcript

Other Identifiers

11747765_a_at

11758204_s_at

16677228

202186_3p_x_at

202186_PM_x_at

202186_x_at

202187_PM_s_at

202187_s_at

2379016

2379017

2379018

2379020

2379021

2379022

2379023

2379024

2379026

2379028

2379029

2379033

2379034

2379035

2379036

2379039

2379040

2379041

2379043

2379045

2379046

2379047

2379048

3805314

42407_at

5525

7909586

903_at

A_14_P126109

A_23_P256432

A_24_P134955

A_24_P251221

GE492961

GE57772

GO:0000159

GO:0000775

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0007165

GO:0019210

GO:0019888

GO:0019900

GO:0030018

GO:0031430

GO:0072542

GO:0098772

GO:1903077

HMNXSV003033871

Hs.155079.0.A1_3p_a_at

Hs.155079.0.A1_3p_at

ILMN_1738784

ILMN_1821279

L42373_at

PH_hs_0009337

TC01001771.hg

g5453949_3p_a_at

Participates

as a component of

Activated PPP2R5A-specific PP2A [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2R5A [cytosol]

Inferred To

phospho-pptr-1 [cytosol] (Caenorhabditis elegans)

phospho-Ppp2r5a [cytosol] (Mus musculus)

phospho-Ppp2r5a [cytosol] (Rattus norvegicus)

phospho-PPP2R5A [cytosol] (Bos taurus)

phospho-PPP2R5A [cytosol] (Canis familiaris)

phospho-PPP2R5A [cytosol] (Sus scrofa)

phospho-psrA [cytosol] (Dictyostelium discoideum)

phospho-par1 [cytosol] (Schizosaccharomyces pombe)

Homologues of p-S28-PPP2R5A [cytosol] (Schizosaccharomyces pombe)

phospho-wdb [cytosol] (Drosophila melanogaster)

phospho-par2 [cytosol] (Schizosaccharomyces pombe)

phospho-RTS1 [cytosol] (Saccharomyces cerevisiae)

phospho-ppp2r5a [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 28

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001186685.1, NP_006234.1

ENSEMBL

ENSP00000261461, ENST00000537030, ENST00000261461, ENSP00000442866, ENSG00000066027

OpenTargets

ENSG00000066027

GeneCards

PPP2R5A

HPA

ENSG00000066027-PPP2R5A

ZINC target

Q15172

PRO

Q15172

Pharos - Targets

Q15172

PDB

6NTS, 8SZK

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.903	8
UniProt:Q5FBB7 SGO1	3	SGOL1 [cytosol] (R-HSA-376227) SGO1 [nucleoplasm] (R-HSA-2468161) p-S-SGO1 [nucleoplasm] (R-HSA-9929718)	0.734	6
UniProt:Q86YF9 DZIP1	1	DZIP1 [nucleoplasm] (R-HSA-5635020)	0.666	4
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.658	3
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.643	4
UniProt:Q9Y2T1 AXIN2	4	Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) RibC-AXIN2 [cytosol] (R-HSA-3640842) AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.527	2

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