Reactome | MBD4 [nucleoplasm]

MBD4 [nucleoplasm]

Stable Identifier

R-HSA-3006633

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MBD4 glycosylase, Methyl-CpG-binding domain protein 4, MBD4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95243 MBD4

Gene Names

MBD4, MED1

Chain

chain:1-580

Reference Genes

BioGPS Gene:8930 MBD4

COSMIC (genes):MBD4 MBD4

CTD Gene:8930 MBD4

dbSNP Gene:8930 MBD4

ENSEMBL:ENSG00000129071 MBD4

ENSEMBL_homo_sapiens_GENE:ENSG00000129071.10 MBD4

HGNC:6919 MBD4

KEGG Gene (Homo sapiens):8930 MBD4

Monarch:8930 MBD4

NCBI Gene:8930 MBD4

OMIM:603574 MBD4

UCSC:O95243 MBD4

Reference Transcript

Other Identifiers

11719798_s_at

11719799_a_at

11756936_a_at

11760224_at

16958989

209579_PM_s_at

209579_s_at

209580_PM_s_at

209580_s_at

214047_PM_s_at

214047_s_at

2694749

2694786

2694787

2694788

2694789

2694791

2694792

2694793

2694794

2694796

2694798

2694800

2694801

2694802

2694803

2694804

2694805

2694806

2694807

2694808

2694809

2694810

34386_at

8090577

8930

A_23_P92154

GE54678

GO:0003677

GO:0003696

GO:0003824

GO:0004520

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006974

GO:0008263

GO:0016607

GO:0016787

GO:0019104

GO:0032355

GO:0043226

GO:0045008

GO:0055086

GO:0140097

GO:1901135

HMNXSV003003936

HMNXSV003021796

Hs.35947.0.S1_3p_a_at

Hs.35947.1.S1_3p_a_at

ILMN_2055310

PH_hs_0002885

TC03001771.hg

Participates

as an output of

Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)

as an input of

as a component of

Inferred To

Mbd4 [nucleoplasm] (Mus musculus)

Mbd4 [nucleoplasm] (Rattus norvegicus)

MBD4 [nucleoplasm] (Bos taurus)

MBD4 [nucleoplasm] (Canis familiaris)

MBD4 [nucleoplasm] (Gallus gallus)

MBD4 [nucleoplasm] (Sus scrofa)

mbd4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001263201.1, NP_001263200.1, NP_001263202.1, NP_003916.1, NP_001263199.1

OpenTargets

ENSG00000129071

HPA

ENSG00000129071-MBD4

GeneCards

O95243

Ensembl

ENSP00000424873, ENSP00000376959, ENSP00000249910, ENST00000429544, ENSP00000394080, ENST00000507208, ENST00000249910, ENSP00000422327, ENST00000393278, ENSG00000129071, ENST00000503197

PRO

O95243

Pharos - Targets

O95243

PDB

4OFH, 4LG7, 4OFE, 3IHO, 4EA5, 4OFA, 7KZG, 7KZ1, 4EA4, 4E9G, 4E9H, 5CHZ, 4E9E, 4DK9, 7KZ0, 4E9F, 2MOE, 6VJW

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.581	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2

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