Reactome | MBD4 [nucleoplasm]

MBD4 [nucleoplasm]

Stable Identifier

R-HSA-3006633

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MBD4 glycosylase, Methyl-CpG-binding domain protein 4, MBD4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95243 MBD4

Gene Names

MBD4, MED1

Chain

chain:1-580

Reference Genes

BioGPS Gene:8930 MBD4

COSMIC (genes):MBD4 MBD4

COSMIC (genes):MED1 MBD4

CTD Gene:8930 MBD4

dbSNP Gene:8930 MBD4

ENSEMBL:ENSG00000129071 MBD4

HGNC:6919 MBD4

KEGG:hsa:8930 MBD4

Monarch:8930 MBD4

NCBI Gene:8930 MBD4

OMIM:603574 MBD4

UCSC:O95243 MBD4

Reference Transcript

Participates

as an output of

Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)

as an input of

as a component of

Inferred To

Mbd4 [nucleoplasm] (Mus musculus)

Mbd4 [nucleoplasm] (Rattus norvegicus)

MBD4 [nucleoplasm] (Bos taurus)

MBD4 [nucleoplasm] (Canis familiaris)

MBD4 [nucleoplasm] (Gallus gallus)

MBD4 [nucleoplasm] (Sus scrofa)

mbd4 [nucleoplasm] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000129071

ENSEMBL

ENSP00000424873, ENSG00000129071, ENSP00000249910, ENST00000249910, ENSP00000394080, ENSP00000422327, ENST00000429544, ENST00000507208, ENST00000393278, ENSP00000376959, ENST00000503197

HPA

ENSG00000129071-MBD4

GeneCards

MBD4

PRO

O95243

Pharos - Targets

O95243

GlyGen

O95243

PDB

7KZ1, 4EA5, 4OFE, 6VJW, 4OFA, 4E9E, 4OFH, 4DK9, 4E9F, 4E9G, 3IHO, 4E9H, 5CHZ, 7KZG, 4LG7, 7KZ0, 2MOE, 4EA4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.581	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2

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