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PSAP(?-?) [extracellular region]
Stable Identifier
R-HSA-5336190
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Prosaptide TX14(A), Proactivator polypeptide (Contains: Saposin-A)
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
GPR37 binds prosaptide (Homo sapiens)
GPR37:PSAP fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
GPR37L binds prosaposin (Homo sapiens)
GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
PSAP fragments [extracellular region] (Homo sapiens)
PSAP(?-?) [extracellular region] (Homo sapiens)
General
TXLIDNNATEEILY where X is a D-alanine
External Reference Information
External Reference
UniProt:P07602 PSAP
Gene Names
PSAP, GLBA, SAP1
Chain
signal peptide:1-16, chain:17-524, propeptide:17-59, chain:60-142, propeptide:143-194, chain:195-274, chain:195-273, propeptide:275-310, chain:311-390, propeptide:393-404, chain:405-486, propeptide:487-524
Reference Genes
BioGPS Gene:5660 PSAP
COSMIC (genes):PSAP PSAP
CTD Gene:5660 PSAP
dbSNP Gene:5660 PSAP
ENSEMBL:ENSG00000197746 PSAP
HGNC:9498 PSAP
KEGG:hsa:5660 PSAP
Monarch:5660 PSAP
NCBI Gene:5660 PSAP
OMIM:176801 PSAP
UCSC:P07602 PSAP
Reference Transcript
RefSeq:NM_001042466.2 PSAP
RefSeq:NM_002778.3 PSAP
RefSeq:NM_001042465.2 PSAP
Other Identifiers
11739069_s_at
11752509_s_at
11752510_x_at
11755296_a_at
16715241
200866_PM_s_at
200866_s_at
200871_PM_s_at
200871_s_at
3293761
3293763
3293764
3293765
3293766
3293767
3293768
3293769
3293770
3293771
3293772
3293773
3293774
3293775
3293776
3293777
3293778
3293779
3293780
3293781
3293782
3293783
3293787
3293788
3293789
3293790
3293793
3293794
3293795
3293800
3293801
36795_at
5660
7934196
A_23_P12680
A_24_P309317
GE81192
GO:0002020
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005886
GO:0006629
GO:0006665
GO:0007041
GO:0007193
GO:0008047
GO:0008289
GO:0010506
GO:0019216
GO:0022414
GO:0030154
GO:0030312
GO:0031012
GO:0031410
GO:0035577
GO:0042802
GO:0042803
GO:0043202
GO:0043226
GO:0043231
GO:0060736
GO:0060742
GO:0062023
GO:0070062
GO:0097110
GO:0098772
GO:1903771
GO:1905572
GO:1905573
GO:1905574
GO:1905575
GO:1905576
GO:1905577
HMNXSV003047545
ILMN_1749109
ILMN_2355559
J03077_s_at
PH_hs_0019280
TC10001374.hg
g11386146_3p_s_at
g337761_3p_a_at
Participates
as a member of
PSAP fragments [extracellular region] (Homo sapiens)
Other forms of this molecule
PSAP(326-340) [extracellular region]
PSAP(17-524) [azurophil granule membrane]
PSAP(17-524) [plasma membrane]
PSAP(195-273) [lysosomal lumen]
PSAP [lysosomal lumen]
PSAP(60-142) [lysosomal lumen]
PSAP(311-391) [lysosomal membrane]
PSAP(405-486) [lysosomal lumen]
PSAP(311-391) [lysosomal lumen]
PSAP(60-142) [extracellular region]
Inferred To
A0A1D5PAE3 [extracellular region]
(Gallus gallus)
PSAP [extracellular region]
(Bos taurus)
PSAP [extracellular region]
(Canis familiaris)
PSAP [extracellular region]
(Sus scrofa)
Psap [extracellular region]
(Mus musculus)
Psap [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002769.1
,
NP_001035930.1
,
NP_001035931.1
OpenTargets
ENSG00000197746
ENSEMBL
ENST00000394936
,
ENSP00000378394
HPA
ENSG00000197746-PSAP
PRO
P07602
Pharos - Targets
P07602
Orphanet
PSAP
GlyGen
P07602
HMDB Protein
HMDBP01673
PDB
4V2O
,
1M12
,
9AVS
,
4DDJ
,
3BQQ
,
4UEX
,
1SN6
,
2GTG
,
9AXG
,
3BQP
,
8EQU
,
2Z9A
,
2QYP
,
6SLR
,
2RB3
,
2R0R
,
1N69
,
2DOB
,
2R1Q
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.702
6
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.666
4
UniProt:P07948 LYN
7
LYN [cytosol]
(R-HSA-354251)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
LYN [plasma membrane]
(R-HSA-197943)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q92624 APBP2
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:P50542-3 PEX5
0.556
3
UniProt:P31944 CASP14
2
CASP14(6-146) [cytosol]
(R-HSA-8847667)
CASP14(153-242) [cytosol]
(R-HSA-8847687)
0.471
3
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