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NGF [cytosol]
Stable Identifier
R-HSA-190059
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nerve Growth Factor, Neurotrophin
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Activation of TRKA receptors (Homo sapiens)
TRKA activation by NGF (Homo sapiens)
Activated TrkA receptor internalizes to endosomes (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
FRS2 binds to active TrkA receptor (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
Active TrkA receptor:FRS2 complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)
Active TrkA receptor:FRS2 complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
p-FRS2 binds CRKL (Homo sapiens)
Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
p-FRS2:CRKL binds C3G (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
beta-NGF homodimer [cytosol] (Homo sapiens)
NGF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01138 NGF
Gene Names
NGF, NGFB
Chain
signal peptide:1-18, propeptide:19-121, chain:122-241
Reference Genes
COSMIC (genes):NGF NGF
dbSNP Gene:4803 NGF
ENSEMBL:ENSG00000134259 NGF
Participates
as a component of
beta-NGF homodimer [cytosol] (Homo sapiens)
Other forms of this molecule
NGF [Golgi lumen]
NGF(19-241) [extracellular region]
NGF(1-241) [endoplasmic reticulum lumen]
NGF(19-241) [Golgi lumen]
NGF(19-241) [endoplasmic reticulum lumen]
NGF [extracellular region]
Inferred To
NGF [cytosol]
(Bos taurus)
NGF [cytosol]
(Canis familiaris)
NGF [cytosol]
(Gallus gallus)
NGF [cytosol]
(Mus musculus)
NGF [cytosol]
(Rattus norvegicus)
NGF [cytosol]
(Sus scrofa)
ngf [cytosol]
(Xenopus tropicalis)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07174 Ngfr
8
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194476)
Ngfr [extracellular region]
(R-RNO-194470)
Ngfr [plasma membrane]
(R-RNO-193664)
0.722
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.683
3
UniProt:Q99523 SORT1
2
SORT1 [Golgi membrane]
(R-HSA-434332)
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
0.676
5
UniProt:P20042 EIF2S2
1
EIF2S2 [cytosol]
(R-HSA-72512)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
9
UniProt:P08138 NGFR
7
NGFR [plasma membrane]
(R-HSA-193664)
NGFR(29-250) [extracellular region]
(R-HSA-194470)
NGFR(251-427) [plasma membrane]
(R-HSA-194476)
NGFR(251-427) [endosome]
(R-HSA-209541)
NGFR(273-427) [cytosol]
(R-HSA-194458)
NGFR(251-272) [plasma membrane]
(R-HSA-194509)
NGFR(273-427) [nucleoplasm]
(R-HSA-197473)
0.544
2
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![NGF [cytosol] icon](/icon/R-ICO-013076.svg){kind=icon}
