Reactome | HS(6)-SDC1 [plasma membrane]

HS(6)-SDC1 [plasma membrane]

Stable Identifier

R-HSA-2076652

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SDC1, syndecan 1

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
    - PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
      - Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
        
        Syndecans1-4 [plasma membrane] (Homo sapiens)
        
        Syndecan-1 [plasma membrane] (Homo sapiens)
        
        HS(6)-SDC1 [plasma membrane] (Homo sapiens)
    - Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
      - Syndecans1-4 [plasma membrane] (Homo sapiens)
        
        Syndecan-1 [plasma membrane] (Homo sapiens)
        
        HS(6)-SDC1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18827 SDC1

Gene Names

SDC1, SDC

Chain

signal peptide:1-22, chain:23-310

Reference Genes

BioGPS Gene:6382 SDC1

COSMIC (genes):SDC1 SDC1

CTD Gene:6382 SDC1

dbSNP Gene:6382 SDC1

ENSEMBL:ENSG00000115884 SDC1

HGNC:10658 SDC1

KEGG:hsa:6382 SDC1

Monarch:6382 SDC1

NCBI Gene:6382 SDC1

OMIM:186355 SDC1

UCSC:P18827 SDC1

Reference Transcript

Other Identifiers

11716577_s_at

11752754_s_at

11758139_s_at

16894911

201286_PM_at

201286_at

201287_PM_s_at

201287_s_at

2542796

2542797

2542798

2542799

2542800

2542801

2542802

2542810

2542811

2542812

2542813

2542814

2542815

38127_at

6382

8050557

A_23_P16944

A_24_P97129

GE60412

GO:0001657

GO:0005515

GO:0005576

GO:0005796

GO:0005886

GO:0006898

GO:0009636

GO:0009897

GO:0009986

GO:0016020

GO:0016192

GO:0016477

GO:0022414

GO:0032991

GO:0038024

GO:0042542

GO:0042802

GO:0043202

GO:0043226

GO:0048627

GO:0048856

GO:0048870

GO:0051384

GO:0051591

GO:0051592

GO:0055002

GO:0060009

GO:0060070

GO:0070062

GO:1903543

GO:1903553

HMNXSV003006280

Hs.82109.0.S2_3p_at

ILMN_1768953

ILMN_1800038

ILMN_1815308

PH_hs_0004693

TC02001619.hg

Z48199_at

g4506858_3p_s_at

Participates

as a member of

Other forms of this molecule

HS(4)-SDC1 [plasma membrane]

HS(2)-SDC1 [plasma membrane]

HS(1)-SDC1 [plasma membrane]

HS(3)-SDC1 [plasma membrane]

HS(5)-SDC1 [plasma membrane]

SDC1 [plasma membrane]

XylS-SDC1 [Golgi lumen]

Gal-Xyl-SDC1 [Golgi lumen]

SDC1 [Golgi lumen]

Gal-Gal-Xyl-SDC1 [Golgi lumen]

GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen]

HS(3)-SDC1 [Golgi lumen]

HS(4)-SDC1 [Golgi lumen]

HS(2)-SDC1 [Golgi lumen]

HS(1)-SDC1 [Golgi lumen]

Heparan(4)-SDC1 [Golgi lumen]

Heparan(3)-SDC1 [Golgi lumen]

Heparan(2)-SDC1 [Golgi lumen]

Heparan(1)-SDC1 [Golgi lumen]

Heparan-SDC1 [Golgi lumen]

HS(5)-SDC1 [Golgi lumen]

HS(6)-SDC1 [Golgi lumen]

HS(6)-SDC1 [lysosomal lumen]

SDC1 [lysosomal lumen]

Inferred To

sdc1 [plasma membrane] (Xenopus tropicalis)

sdn-1 [plasma membrane] (Caenorhabditis elegans)

SDC1 [plasma membrane] (Bos taurus)

SDC1 [plasma membrane] (Canis familiaris)

SDC1 [plasma membrane] (Gallus gallus)

SDC1 [plasma membrane] (Sus scrofa)

Sdc [plasma membrane] (Drosophila melanogaster)

Sdc1 [plasma membrane] (Mus musculus)

Sdc1 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O-xylosyl-L-serine (ChEBI:63666) at unknown position

Modification

beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

NP_002988.3, NP_001006947.1

OpenTargets

ENSG00000115884

ENSEMBL

ENSP00000254351, ENST00000254351, ENSP00000370542, ENST00000381150

HPA

ENSG00000115884-SDC1

PRO

P18827

Pharos - Targets

P18827

GlyGen

P18827

HMDB Protein

HMDBP02143

PDB

6EJE, 4GVD, 4GVC

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13009 TIAM1	2	TIAM1 [cytosol] (R-HSA-195013) p-Y829-TIAM1 [cytosol] (R-HSA-3928461)	0.655	5
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.59	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) SDC1 [Golgi lumen] (R-HSA-2054105) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349)	0.542	2
UniProt:P0DTL6 ZTRF1			0.527	2
UniProt:Q8NCB2 CAMKV			0.527	2
UniProt:Q9HAV0 GNB4	4	GNB4 [plasma membrane] (R-HSA-164326) Unfolded GNB4 [cytosol] (R-HSA-6814201) Partially folded GNB4 [cytosol] (R-HSA-8850525) GNB4 [cytosol] (R-HSA-6814417)	0.527	2
UniProt:Q9Y4F1 FARP1	1	FARP1 [cytosol] (R-HSA-9679578)	0.527	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.527	2
UniProt:Q01581 HMGCS1	1	HMGCS1 [cytosol] (R-HSA-191329)	0.527	2
UniProt:Q9C0B1 FTO	1	FTO [nucleoplasm] (R-HSA-8857715)	0.527	2
UniProt:Q9UKD1 GMEB2			0.527	2
UniProt:Q13268 DHRS2			0.527	2
UniProt:Q7L9B9 EEPD1	1	EEPD1 [plasma membrane] (R-HSA-9035163)	0.527	2
UniProt:Q16625 OCLN	4	OCLN [plasma membrane] (R-HSA-351846) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944)	0.527	2
UniProt:P78368 CSNK1G2	2	CSNK1G2 [cytosol] (R-HSA-429696) CSNK1G2 [plasma membrane] (R-HSA-205718)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	3

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