Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TP53BP2 [nucleoplasm]
Stable Identifier
R-HSA-6799780
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Apoptosis-stimulating of p53 protein 2, ASPP2, Bcl2-binding protein, Bbp, 53BP2, p53-binding protein 2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members bind the FAS gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members bind the BAX promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate BAX transcription (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13625 TP53BP2
Gene Names
TP53BP2, ASPP2, BBP
Chain
chain:1-1128
Reference Genes
BioGPS Gene:7159 TP53BP2
COSMIC (genes):TP53BP2 TP53BP2
CTD Gene:7159 TP53BP2
dbSNP Gene:7159 TP53BP2
ENSEMBL:ENSG00000143514.17 TP53BP2
HGNC:12000 TP53BP2
KEGG Gene (Homo sapiens):7159 TP53BP2
Monarch:7159 TP53BP2
NCBI Gene:7159 TP53BP2
OMIM:602143 TP53BP2
UCSC:Q13625 TP53BP2
Reference Transcript
RefSeq:XM_011544269.2 TP53BP2
RefSeq:NM_001031685.2 TP53BP2
RefSeq:NM_005426.2 TP53BP2
Other Identifiers
0001980168
11720211_a_at
11741099_a_at
11757945_s_at
16699706
1860_at
203120_PM_at
203120_at
236177_PM_s_at
236177_s_at
2457843
2457844
2457845
2457851
2457853
2457854
2457855
2457857
2457858
2457859
2457860
2457861
2457862
2457864
2457866
2457867
2457868
2457869
2457870
2457871
2457873
2457874
2457876
2457881
2457883
34822_at
7159
7924526
88865_at
A_23_P12526
GE59258
GO:0002039
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006915
GO:0007049
GO:0007165
GO:0012501
GO:0017124
GO:0023052
GO:0030054
GO:0042802
GO:0043226
GO:0045786
GO:0048471
GO:0051059
GO:0072332
GO:1900119
HMNXSV003010899
Hs.126680.0.A1_3p_a_at
ILMN_1779706
ILMN_2270299
PH_hs_0003232
TC01003874.hg
U58334_at
Participates
as a member of
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
Inferred To
Tp53bp2 [nucleoplasm]
(Mus musculus)
Tp53bp2 [nucleoplasm]
(Rattus norvegicus)
tp53bp2 [nucleoplasm]
(Xenopus tropicalis)
TP53BP2 [nucleoplasm]
(Bos taurus)
TP53BP2 [nucleoplasm]
(Canis familiaris)
TP53BP2 [nucleoplasm]
(Danio rerio)
TP53BP2 [nucleoplasm]
(Gallus gallus)
TP53BP2 [nucleoplasm]
(Sus scrofa)
ASPP [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011542571.1
,
NP_001026855.2
,
NP_005417.1
OpenTargets
ENSG00000143514
GeneCards
Q13625
HPA
ENSG00000143514-TP53BP2
Ensembl
ENSP00000375750
,
ENSG00000143514
,
ENSP00000341957
,
ENST00000391878
,
ENST00000343537
PRO
Q13625
Pharos - Targets
Q13625
PDB
6HKP
,
2UWQ
,
4IRV
,
6GHM
,
4A63
,
1YCS
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.903
9
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.857
9
UniProt:P46937 YAP1
7
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
0.777
6
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.669
3
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.655
10
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.581
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.576
5
UniProt:Q04206 RELA
6
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.558
4
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.499
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![TP53BP2 [nucleoplasm] icon](/icon/R-ICO-012449.svg){kind=icon}
