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TP53BP2 [nucleoplasm]
Stable Identifier
R-HSA-6799780
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Apoptosis-stimulating of p53 protein 2, ASPP2, Bcl2-binding protein, Bbp, 53BP2, p53-binding protein 2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members bind the FAS gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members bind the BAX promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate BAX transcription (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13625 TP53BP2
Gene Names
TP53BP2, ASPP2, BBP
Chain
chain:1-1128
Reference Genes
COSMIC (genes):TP53BP2 TP53BP2
ENSEMBL:ENSG00000143514 TP53BP2
HGNC:12000 TP53BP2
UCSC:Q13625 TP53BP2
Participates
as a member of
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
Inferred To
Tp53bp2 [nucleoplasm]
(Mus musculus)
Tp53bp2 [nucleoplasm]
(Rattus norvegicus)
tp53bp2 [nucleoplasm]
(Xenopus tropicalis)
TP53BP2 [nucleoplasm]
(Bos taurus)
TP53BP2 [nucleoplasm]
(Canis familiaris)
TP53BP2 [nucleoplasm]
(Gallus gallus)
TP53BP2 [nucleoplasm]
(Sus scrofa)
ASPP [nucleoplasm]
(Drosophila melanogaster)
tp53bp2a [nucleoplasm]
(Danio rerio)
Cross References
ENSEMBL
ENSP00000341957
,
ENST00000391878
,
ENSG00000143514
,
ENSP00000375750
,
ENST00000343537
OpenTargets
ENSG00000143514
HPA
ENSG00000143514-TP53BP2
PRO
Q13625
Pharos - Targets
Q13625
GlyGen
Q13625
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.915
12
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.903
9
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.892
10
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.763
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
5
UniProt:P46937 YAP1
8
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
0.671
5
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.655
10
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.581
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
0.576
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.569
4
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.558
4
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.499
2
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