Reactome | TP53BP2 [nucleoplasm]

TP53BP2 [nucleoplasm]

Stable Identifier

R-HSA-6799780

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apoptosis-stimulating of p53 protein 2, ASPP2, Bcl2-binding protein, Bbp, 53BP2, p53-binding protein 2

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members bind the FAS gene (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 family members bind the BAX promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 family members stimulate BAX transcription (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of PUMA and translocation to mitochondria (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        TP53BP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13625 TP53BP2

Gene Names

TP53BP2, ASPP2, BBP

Chain

chain:1-1128

Reference Genes

BioGPS Gene:7159 TP53BP2

COSMIC (genes):TP53BP2 TP53BP2

CTD Gene:7159 TP53BP2

dbSNP Gene:7159 TP53BP2

ENSEMBL:ENSG00000143514 TP53BP2

HGNC:12000 TP53BP2

KEGG Gene (Homo sapiens):7159 TP53BP2

Monarch:7159 TP53BP2

NCBI Gene:7159 TP53BP2

OMIM:602143 TP53BP2

UCSC:Q13625 TP53BP2

Reference Transcript

Other Identifiers

0001980168

11720211_a_at

11741099_a_at

11757945_s_at

16699706

1860_at

203120_at

21603

236177_s_at

2457843

2457844

2457845

2457851

2457853

2457854

2457855

2457857

2457858

2457859

2457860

2457861

2457862

2457864

2457866

2457867

2457868

2457869

2457870

2457871

2457873

2457874

2457876

2457881

2457883

34822_at

50429

7159

7924526

88865_at

A_23_P12526

CCDS1538

CCDS44319

ENSG00000143514

ENSP00000341957

ENSP00000375750

ENST00000343537

ENST00000343537.11

ENST00000391878

ENST00000391878.6

EntrezGene:7159

EntrezGene:TP53BP2

F8WBY9

GE59258

GO:0002039

GO:0003674

GO:0005070

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006810

GO:0006915

GO:0007005

GO:0007049

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0017124

GO:0030054

GO:0030674

GO:0042802

GO:0042981

GO:0043226

GO:0045786

GO:0048471

GO:0051059

GO:0061024

GO:0072332

GO:1900119

GO:1900740

GO:1901216

GO:1901796

HGNC:12000

HPA021603

HPA050429

Hs.126680.0.A1_3p_a_at

ILMN_1779706

ILMN_2270299

IPR001452

IPR002110

IPR020683

IPR029071

IPR036028

IPR036770

MIM:602143

NM_001031685

NM_005426

NP_001026855

NP_005417

PF00018

PF12796

PH_hs_0003232

PR01887

SM00248

SM00326

TC01003874.hg

TP53BP2

TP53BP2-201

TP53BP2-202

U58334_at

UPI0000131032

UPI0000D4B5F2

XM_011544268

XM_011544269

XP_011542570

XP_011542571

Participant Of

hasMember

PPP1R13B,TP53BP2 [nucleoplasm]

Inferred To

TP53BP2 [nucleoplasm] (Bos taurus)

TP53BP2 [nucleoplasm] (Canis familiaris)

TP53BP2 [nucleoplasm] (Danio rerio)

TP53BP2 [nucleoplasm] (Drosophila melanogaster)

TP53BP2 [nucleoplasm] (Gallus gallus)

TP53BP2 [nucleoplasm] (Mus musculus)

TP53BP2 [nucleoplasm] (Rattus norvegicus)

TP53BP2 [nucleoplasm] (Sus scrofa)

TP53BP2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001026855.2, XP_011542571.1, NP_005417.1

OpenTargets

ENSG00000143514

GeneCards

Q13625

PRO

Q13625

PDB

4A63, 1YCS, 2UWQ, 4IRV, 6GHM, 6HKP

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.903	9
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.86	9
UniProt:P46937 YAP1	7	p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.69	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.669	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.655	10
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.581	3
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.576	5
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642)	0.558	4
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.499	2