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TP53BP2 [nucleoplasm]
Stable Identifier
R-HSA-6799780
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Apoptosis-stimulating of p53 protein 2, ASPP2, Bcl2-binding protein, Bbp, 53BP2, p53-binding protein 2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members bind the FAS gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members bind the BAX promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 family members stimulate BAX transcription (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
TP53BP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13625 TP53BP2
Gene Names
TP53BP2, ASPP2, BBP
Chain
chain:1-1128
Reference Genes
BioGPS Gene:7159 TP53BP2
COSMIC (genes):TP53BP2 TP53BP2
CTD Gene:7159 TP53BP2
dbSNP Gene:7159 TP53BP2
ENSEMBL:ENSG00000143514 TP53BP2
HGNC:12000 TP53BP2
KEGG Gene (Homo sapiens):7159 TP53BP2
Monarch:7159 TP53BP2
NCBI Gene:7159 TP53BP2
OMIM:602143 TP53BP2
UCSC:Q13625 TP53BP2
Reference Transcript
RefSeq:NM_005426.2 TP53BP2
RefSeq:XM_011544269.2 TP53BP2
RefSeq:NM_001031685.2 TP53BP2
Other Identifiers
0001980168
11720211_a_at
11741099_a_at
11757945_s_at
16699706
1860_at
203120_at
236177_s_at
2457843
2457844
2457845
2457851
2457853
2457854
2457855
2457857
2457858
2457859
2457860
2457861
2457862
2457864
2457866
2457867
2457868
2457869
2457870
2457871
2457873
2457874
2457876
2457881
2457883
34822_at
7159
7924526
88865_at
A_23_P12526
GE59258
GO:0002039
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006810
GO:0006915
GO:0007005
GO:0007049
GO:0007165
GO:0008134
GO:0008150
GO:0008219
GO:0015031
GO:0017124
GO:0030054
GO:0042802
GO:0042981
GO:0043226
GO:0045786
GO:0048471
GO:0051059
GO:0061024
GO:0072332
GO:1900119
GO:1900740
GO:1901216
GO:1901796
HMNXSV003010899
Hs.126680.0.A1_3p_a_at
ILMN_1779706
ILMN_2270299
PH_hs_0003232
TC01003874.hg
U58334_at
Participates
as a member of
PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
Inferred To
Tp53bp2 [nucleoplasm]
(Mus musculus)
Tp53bp2 [nucleoplasm]
(Rattus norvegicus)
TP53BP2 [nucleoplasm]
(Bos taurus)
TP53BP2 [nucleoplasm]
(Canis familiaris)
TP53BP2 [nucleoplasm]
(Gallus gallus)
TP53BP2 [nucleoplasm]
(Sus scrofa)
TP53BP2 [nucleoplasm]
(Xenopus tropicalis)
ASPP [nucleoplasm]
(Drosophila melanogaster)
tp53bp2a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_011542571.1
,
NP_001026855.2
,
NP_005417.1
OpenTargets
ENSG00000143514
GeneCards
Q13625
HPA
ENSG00000143514-TP53BP2
Ensembl
ENSP00000341957
,
ENSP00000375750
,
ENST00000343537
,
ENST00000391878
,
ENSG00000143514
PRO
Q13625
Pharos - Targets
Q13625
GlyGen
Q13625
PDB
2UWQ
,
6HKP
,
4IRV
,
1YCS
,
4A63
,
6GHM
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 [cytosol]
(R-HSA-8869337)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
0.903
9
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.857
9
UniProt:P46937 YAP1
7
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
0.671
5
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.669
3
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.655
10
UniProt:P05067 APP
20
APP(672-711) [extracellular region]
(R-HSA-976740)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.581
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
0.576
5
UniProt:Q04206 RELA
6
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
RELA [nucleoplasm]
(R-HSA-177676)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
0.558
4
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
0.499
2
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