Reactome | p-4S,T336-ELK1 [nucleoplasm]

p-4S,T336-ELK1 [nucleoplasm]

Stable Identifier

R-HSA-3009350

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p(4S,T)-ELK1, ETS domain-containing protein Elk-1, ELK1_HUMAN, ELK1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERK1/2 activates ELK1 (Homo sapiens)
        
        p-4S,T336-ELK1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19419 ELK1

Gene Names

ELK1

Chain

chain:1-428

Reference Genes

BioGPS Gene:2002 ELK1

COSMIC (genes):ELK1 ELK1

CTD Gene:2002 ELK1

dbSNP Gene:2002 ELK1

ENSEMBL:ENSG00000126767 ELK1

ENSEMBL_homo_sapiens_GENE:ENSG00000126767.18 ELK1

HGNC:3321 ELK1

KEGG Gene (Homo sapiens):2002 ELK1

Monarch:2002 ELK1

NCBI Gene:2002 ELK1

OMIM:311040 ELK1

UCSC:P19419 ELK1

Reference Transcript

Other Identifiers

11734040_s_at

11741120_a_at

11751831_a_at

17110481

1781_at

2002

203617_3p_x_at

203617_PM_x_at

203617_x_at

210376_3p_x_at

210376_PM_x_at

210376_x_at

210850_PM_s_at

210850_s_at

33275_at

3581632

3581755

3581761

4007185

4007187

4007188

4007189

4007190

4007191

4007192

4007194

4007195

4007197

4007198

4007199

4007200

4007204

4007206

4007207

4007208

4007210

4007211

8172345

A_23_P171054

A_33_P3386099

GE79564

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001889

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005739

GO:0006351

GO:0006355

GO:0006357

GO:0009416

GO:0010467

GO:0012501

GO:0030324

GO:0030374

GO:0030425

GO:0031966

GO:0043025

GO:0043226

GO:0043565

GO:0043679

GO:0045893

GO:0045944

GO:0048856

GO:0061629

GO:0071394

GO:0071396

GO:0071480

GO:0071774

GO:0110088

GO:0140110

GO:1990837

HMNXSV003007022

Hs.247775.0.S1_3p_s_at

ILMN_1654289

ILMN_1779282

M25269_at

PH_hs_0032029

TC0X000999.hg

g11496880_3p_at

g11496880_3p_s_at

g11496880_3p_x_at

g4100455_3p_a_at

g538208_3p_a_at

g538208_3p_s_at

Participates

as a component of

as an input of

as an output of

ERK1/2 activates ELK1 (Homo sapiens)

Other forms of this molecule

ELK1 [nucleoplasm]

Modified Residues

Name

O-phospho-L-serine at 324

Coordinate

324

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 383

Coordinate

383

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 389

Coordinate

389

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 422

Coordinate

422

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 336

Coordinate

336

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001244097.1, NP_001107595.1, NP_005220.2, XP_016884828.1

OpenTargets

ENSG00000126767

HPA

ENSG00000126767-ELK1

GeneCards

P19419

Ensembl

ENST00000343894, ENSG00000126767, ENSP00000247161, ENST00000376983, ENST00000247161, ENSP00000366182, ENSP00000345585

PRO

P19419

Pharos - Targets

P19419

PDB

5VVT, 1DUX

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.734	7
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.656	5
IntAct:EBI-21348901 TERT			0.632	4
UniProt:O00358 FOXE1			0.625	8
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.571	2
IntAct:EBI-9538914 PSEN1			0.558	2
UniProt:Q06787-7 FMR1			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	5
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2