Reactome | REV3L [nucleoplasm]

REV3L [nucleoplasm]

Stable Identifier

R-HSA-110278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA polymerase zeta catalytic subunit, hREV3, REV3, Protein reversionless 3-like, POLZ

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60673 REV3L

Gene Names

REV3L, POLZ, REV3

Chain

chain:1-3130

Reference Genes

BioGPS Gene:5980 REV3L

COSMIC (genes):REV3L REV3L

CTD Gene:5980 REV3L

dbSNP Gene:5980 REV3L

ENSEMBL:ENSG00000009413 REV3L

ENSEMBL_homo_sapiens_GENE:ENSG00000009413.17 REV3L

HGNC:9968 REV3L

Monarch:5980 REV3L

NCBI Gene:5980 REV3L

OMIM:602776 REV3L

UCSC:O60673 REV3L

Reference Transcript

Other Identifiers

11740540_a_at

11746351_a_at

17022623

208070_PM_s_at

208070_s_at

2969680

2969681

2969688

2969690

2969691

2969692

2969695

2969701

2969703

2969707

2969708

2969709

2969712

2969715

2969717

2969721

2969722

2969724

2969725

2969726

2969729

2969730

2969731

2969732

2969734

2969737

2969738

2969740

2969742

2969745

2969750

2969751

2969755

2969757

2969758

2969772

2969783

2969784

2969785

2969786

2969787

38908_s_at

5980

73965_s_at

8128894

A_23_P214139

GE54710

GO:0000166

GO:0000724

GO:0003676

GO:0003677

GO:0003824

GO:0003887

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006260

GO:0006261

GO:0006281

GO:0006310

GO:0006974

GO:0016035

GO:0016740

GO:0016779

GO:0019985

GO:0031981

GO:0042276

GO:0043226

GO:0046872

GO:0051536

GO:0051539

GO:0140097

HMNXSV003016894

HMNXSV003025527

ILMN_2199947

PH_hs_0023158

TC06002017.hg

g4506482_3p_a_at

Participates

as an input of

Formation of Pol zeta complex (Homo sapiens)

as a component of

POLZ [nucleoplasm] (Homo sapiens)

Inferred To

rev3l [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of REV3L [nucleoplasm] (Danio rerio)

REV3L [nucleoplasm] (Bos taurus)

REV3L [nucleoplasm] (Canis familiaris)

REV3L [nucleoplasm] (Drosophila melanogaster)

REV3L [nucleoplasm] (Gallus gallus)

REV3L [nucleoplasm] (Mus musculus)

REV3L [nucleoplasm] (Plasmodium falciparum)

REV3L [nucleoplasm] (Saccharomyces cerevisiae)

REV3L [nucleoplasm] (Schizosaccharomyces pombe)

REV3L [nucleoplasm] (Sus scrofa)

rev-3 [nucleoplasm] (Caenorhabditis elegans)

Rev3l [nucleoplasm] (Rattus norvegicus)

polZ [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001273361.1, NP_001273360.1, NP_002903.3

OpenTargets

ENSG00000009413

GeneCards

O60673

HPA

ENSG00000009413-REV3L

Ensembl

ENSP00000351697, ENST00000435970, ENST00000368802, ENSP00000402003, ENST00000358835, ENSP00000357792, ENSG00000009413

PRO

O60673

Pharos - Targets

O60673

Orphanet

23362

HMDB Protein

HMDBP00959

PDB

3VU7, 3ABD, 5O8K, 4GK0, 6BC8, 6BI7, 6WS0, 4GK5, 4EXT, 6BCD, 6WS5, 3ABE, 6EKM, 6KEA

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.639	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2