Reactome | PRNP [plasma membrane]

PRNP [plasma membrane]

Stable Identifier

R-HSA-375060

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Major prion protein, PRIO_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04156 PRNP

Gene Names

PRNP, ALTPRP, PRIP, PRP

Chain

signal peptide:1-22, chain:23-230, propeptide:231-253

Reference Genes

COSMIC (genes):PRNP PRNP

dbSNP Gene:5621 PRNP

ENSEMBL:ENSG00000171867 PRNP

Participates

as a component of

NCAM-1:Major prion protein [plasma membrane] (Homo sapiens)

as an input of

Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)

Other forms of this molecule

PRNP [cytosol]

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.975	33
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.775	6
UniProt:P05067-PRO_0000000092 APP			0.667	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.609	2
UniProt:Q13642 FHL1			0.59	3
UniProt:P29372 MPG	1	MPG [nucleoplasm] (R-HSA-49155)	0.571	4
UniProt:Q9BSJ6 PIMRE			0.571	5
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.571	4
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.571	4
UniProt:P10279 PRIO			0.564	5
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.553	3
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.553	3
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.537	4
UniProt:Q8N3V7 SYNPO			0.527	2
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.499	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.499	4
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.499	4
UniProt:P32246 CCR1	1	CCR1 [plasma membrane] (R-HSA-373107)	0.454	2
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.454	2
UniProt:P25105 PTAFR	3	PTAFR [tertiary granule membrane] (R-HSA-6804787) PTAFR [secretory granule membrane] (R-HSA-6804792) PTAFR [plasma membrane] (R-HSA-419376)	0.454	2

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