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G76-NEDD8-C237-UBA3 [cytosol]
Stable Identifier
R-HSA-8951640
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDD8-activating enzyme E1 catalytic subunit, UBA3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)
AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)
AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)
AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 [cytosol] (Homo sapiens)
NEDD8-UBA3 [cytosol] (Homo sapiens)
G76-NEDD8-C237-UBA3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TBC4 UBA3
Gene Names
UBA3, UBE1C
Chain
initiator methionine:, chain:2-463
Reference Genes
BioGPS Gene:9039 UBA3
COSMIC (genes):UBA3 UBA3
CTD Gene:9039 UBA3
dbSNP Gene:9039 UBA3
ENSEMBL:ENSG00000144744 UBA3
ENSEMBL_homo_sapiens_GENE:ENSG00000144744.18 UBA3
HGNC:12470 UBA3
KEGG Gene (Homo sapiens):9039 UBA3
Monarch:9039 UBA3
NCBI Gene:9039 UBA3
OMIM:603172 UBA3
UCSC:Q8TBC4 UBA3
Reference Transcript
RefSeq:NM_198195.1 UBA3
RefSeq:NM_003968.3 UBA3
Other Identifiers
11730728_a_at
16956055
209115_PM_at
209115_at
2681196
2681197
2681198
2681199
2681200
2681201
2681203
2681205
2681207
2681208
2681210
2681212
2681215
2681216
2681217
2681218
2681219
2681221
2681224
2681225
2681228
2681230
2681235
2681238
40066_at
8088718
9039
A_23_P211840
GE54399
GO:0000166
GO:0000278
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006508
GO:0007049
GO:0007113
GO:0008641
GO:0016740
GO:0016874
GO:0019781
GO:0019788
GO:0032991
GO:0036211
GO:0042802
GO:0043226
GO:0043687
GO:0045116
GO:0046982
GO:0051726
GO:0140096
GO:0140657
HMNXSV003011768
ILMN_1689142
ILMN_2324157
PH_hs_0029245
TC03001538.hg
g5912116_3p_at
Participates
as a component of
NEDD8-UBA3 [cytosol] (Homo sapiens)
Other forms of this molecule
UBA3 [cytosol]
Inferred To
Ghost homologue of G76-NEDD8-C237-UBA3 [cytosol]
(Xenopus tropicalis)
UBA3 [cytosol]
(Bos taurus)
UBA3 [cytosol]
(Canis familiaris)
UBA3 [cytosol]
(Gallus gallus)
UBA3 [cytosol]
(Sus scrofa)
G76-NEDD8-C237-UBA3 [cytosol]
(Caenorhabditis elegans)
G76-NEDD8-C237-UBA3 [cytosol]
(Danio rerio)
G76-NEDD8-C237-UBA3 [cytosol]
(Dictyostelium discoideum)
G76-NEDD8-C237-UBA3 [cytosol]
(Drosophila melanogaster)
G76-NEDD8-C237-UBA3 [cytosol]
(Mus musculus)
G76-NEDD8-C237-UBA3 [cytosol]
(Plasmodium falciparum)
G76-NEDD8-C237-UBA3 [cytosol]
(Rattus norvegicus)
G76-NEDD8-C237-UBA3 [cytosol]
(Saccharomyces cerevisiae)
G76-NEDD8-C237-UBA3 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 237 and 76
Coordinate
237
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003959.3
,
NP_937838.1
OpenTargets
ENSG00000144744
HPA
ENSG00000144744-UBA3
GeneCards
Q8TBC4
Ensembl
ENSP00000340041
,
ENSP00000354340
,
ENST00000349511
,
ENSG00000144744
,
ENST00000361055
PRO
Q8TBC4
Pharos - Targets
Q8TBC4
PDB
1YOV
,
3GZN
,
3DBL
,
2NVU
,
5JJM
,
2LQ7
,
3DBH
,
1R4N
,
3DBR
,
1R4M
,
1Y8X
,
1TT5
,
3FN1
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.825
5
UniProt:O14732 IMPA2
1
IMPA2 [cytosol]
(R-HSA-1604572)
0.718
6
UniProt:Q96FN4 CPNE2
0.718
6
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.666
4
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.564
6
UniProt:Q13564 NAE1
1
NAE1 [cytosol]
(R-HSA-8951449)
0.556
3
UniProt:Q9BVJ7 DUS23
0.556
3
UniProt:P02649 APOE
10
APOE [early endosome]
(R-HSA-2429687)
APOE [endosome lumen]
(R-HSA-174804)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE [extracellular region]
(R-HSA-174646)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
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