Reactome | G76-NEDD8-C237-UBA3 [cytosol]

G76-NEDD8-C237-UBA3 [cytosol]

Stable Identifier

R-HSA-8951640

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 catalytic subunit, UBA3_HUMAN

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External Reference Information

External Reference

UniProt:Q8TBC4 UBA3

Gene Names

UBA3, UBE1C

Chain

initiator methionine:1, chain:2-463

Reference Genes

BioGPS Gene:9039 UBA3

COSMIC (genes):UBA3 UBA3

CTD Gene:9039 UBA3

dbSNP Gene:9039 UBA3

ENSEMBL:ENSG00000144744 UBA3

HGNC:12470 UBA3

KEGG Gene (Homo sapiens):9039 UBA3

Monarch:9039 UBA3

NCBI Gene:9039 UBA3

OMIM:603172 UBA3

UCSC:Q8TBC4 UBA3

Reference Transcript

Other Identifiers

11730728_a_at

16956055

209115_at

2681196

2681197

2681198

2681199

2681200

2681201

2681203

2681205

2681207

2681208

2681210

2681212

2681215

2681216

2681217

2681218

2681219

2681221

2681224

2681225

2681228

2681230

2681235

2681238

40066_at

8088718

9039

GE54399

GO:0000166

GO:0000278

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0006508

GO:0007049

GO:0007113

GO:0008134

GO:0008150

GO:0008641

GO:0009058

GO:0016874

GO:0016922

GO:0019781

GO:0019788

GO:0032446

GO:0032991

GO:0034641

GO:0042802

GO:0043167

GO:0043226

GO:0043687

GO:0044877

GO:0045116

GO:0045892

GO:0046982

GO:0051726

ILMN_1809281

PH_hs_0029245

TC03001538.hg

g5912116_3p_at

Participant Of

hasComponent

NEDD8-UBA3 [cytosol]

Other forms of this molecule

UBA3 [cytosol]

Inferred To

rfl-1 [cytosol] (Caenorhabditis elegans)

uba3 [cytosol] (Danio rerio)

uba3 [cytosol] (Dictyostelium discoideum)

uba3 [cytosol] (Schizosaccharomyces pombe)

uba3 [cytosol] (Xenopus tropicalis)

UBA3 [cytosol] (Bos taurus)

UBA3 [cytosol] (Canis familiaris)

UBA3 [cytosol] (Gallus gallus)

UBA3 [cytosol] (Saccharomyces cerevisiae)

G76-NEDD8-C237-UBA3 [cytosol] (Plasmodium falciparum)

G76-NEDD8-C237-UBA3 [cytosol] (Sus scrofa)

Uba3 [cytosol] (Drosophila melanogaster)

Uba3 [cytosol] (Mus musculus)

Uba3 [cytosol] (Rattus norvegicus)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 237 and 76

Coordinate

237

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_003959.3, NP_937838.1

OpenTargets

ENSG00000144744

GeneCards

Q8TBC4

HPA

ENSG00000144744-UBA3

Ensembl

ENSG00000144744, ENST00000361055, ENST00000349511, ENSP00000354340, ENSP00000340041

PRO

Q8TBC4

PDB

3DBR, 5JJM, 3DBL, 1TT5, 2LQ7, 1Y8X, 1R4M, 1YOV, 3GZN, 3FN1, 2NVU, 1R4N, 3DBH

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14732 IMPA2	1	IMPA2 [cytosol] (R-HSA-1604572)	0.718	6
UniProt:Q96FN4 CPNE2			0.718	6
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627)	0.704	3
UniProt:Q8TBC4 UBA3	2	G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640) UBA3 [cytosol] (R-HSA-947632)	0.666	4
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.564	6
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.556	3
UniProt:P02649 APOE	9	APOE [endosome lumen] (R-HSA-174804) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.556	3
UniProt:Q9BVJ7 DUS23			0.556	3

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