Reactome | Ub-C85-UBE2D2 [nucleoplasm]

Ub-C85-UBE2D2 [nucleoplasm]

Stable Identifier

R-HSA-8864153

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 D2 ecNumber evidence="13 15 16 17"2.3.2.23/ecNumber, UB2D2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C85-UBE2D2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62837 UBE2D2

Gene Names

UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B

Chain

chain:1-147

Reference Genes

BioGPS Gene:7322 UBE2D2

COSMIC (genes):UBE2D2 UBE2D2

CTD Gene:7322 UBE2D2

dbSNP Gene:7322 UBE2D2

ENSEMBL:ENSG00000131508 UBE2D2

HGNC:12475 UBE2D2

KEGG:hsa:7322 UBE2D2

Monarch:7322 UBE2D2

NCBI Gene:7322 UBE2D2

OMIM:602962 UBE2D2

UCSC:P62837 UBE2D2

Reference Transcript

Other Identifiers

11722198_a_at

11756859_a_at

11757555_s_at

16989881

201343_PM_at

201343_at

201344_PM_at

201344_at

201345_PM_s_at

201345_s_at

2831285

2831290

2831291

2831292

2831294

2831297

2831298

2831299

2831300

2831301

2831303

2831304

2831307

2831308

2831309

2831310

2831311

38705_at

4038316

50909_at

7322

8108435

832_at

A_14_P107754

A_23_P305677

A_23_P58622

A_33_P3310674

GE61672

GO:0000166

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0006511

GO:0016567

GO:0016740

GO:0032991

GO:0036211

GO:0051865

GO:0061630

GO:0061631

GO:0070062

GO:0070936

GO:0140096

HMNXSV003048923

Hs.108332.0.S2_3p_at

Hs.108332.0.S3_3p_at

ILMN_1677756

ILMN_1699503

ILMN_1725644

PH_hs_0006001

TC05000713.hg

TC05002650.hg

U39317_at

g4507774_3p_a_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-C85-UBE2D2 [cytosol]

UBE2D2 [cytosol]

UBE2D2 [nucleoplasm]

Inferred To

UBE2D2 [nucleoplasm] (Bos taurus)

UBE2D2 [nucleoplasm] (Canis familiaris)

UBE2D2 [nucleoplasm] (Gallus gallus)

UBE2D2 [nucleoplasm] (Sus scrofa)

Homologues of Ub-C85-UBE2D2 [nucleoplasm] (Dictyostelium discoideum)

Ube2d2 [nucleoplasm] (Mus musculus)

Ube2d2 [nucleoplasm] (Rattus norvegicus)

ubcB [nucleoplasm] (Dictyostelium discoideum)

ube2d2 [nucleoplasm] (Danio rerio)

Ub-C85-UBE2D2 [nucleoplasm] (Dictyostelium discoideum)

Ub-C85-UBE2D2 [nucleoplasm] (Plasmodium falciparum)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 85

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

XP_047273647.1, NP_862821.1, NP_003330.1

Guide to Pharmacology - Targets

3229

OpenTargets

ENSG00000131508

ENSEMBL

ENSP00000381717, ENST00000511725, ENSP00000513666, ENST00000698321, ENST00000698322, ENSP00000424941, ENSP00000429613, ENSG00000131508, ENSP00000513667, ENST00000398733, ENST00000505548, ENST00000398734, ENSP00000381718

GeneCards

UBE2D2

HPA

ENSG00000131508-UBE2D2

PRO

P62837

Pharos - Targets

P62837

GlyGen

P62837

HMDB Protein

HMDBP00587

PDB

4V3K, 8GBQ, 2CLW, 5D0M, 4V3L, 8V0D, 6TTU, 5MNJ, 5ZBU, 6W7Z, 3JW0, 6SQO, 8B3I, 3L1Y, 6SQS, 2ESK, 5ULK, 8VK8, 8JWU, 8JWJ, 2ESQ, 6M2C, 8GCB, 5D1M, 3JVZ, 4AUQ, 5EDV, 4A4B, 6W9D, 4DDI, 6SQR, 4DDG, 3TGD, 4A49, 7AI0, 8GRM, 7R71, 7AI1, 3ZNI, 5D0K, 7BOL, 4LDT, 4WZ3, 3A33, 5ULH, 2ESO, 8VK9, 1UR6, 2ESP, 1W4U, 5ULF, 5VZW, 5D1L, 5D1K, 6HPR, 4A4C

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.919	18
UniProt:Q9Y3C5 RNF11			0.836	10
IntAct:EBI-4399559 UBIQ			0.835	9
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.824	9
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.804	6
UniProt:Q8ND25 ZNRF1	1	ZNRF1 [cytosol] (R-HSA-8850903)	0.788	7
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.708	5
UniProt:Q9Y4L5 RNF115	1	RNF115 [cytosol] (R-HSA-8850904)	0.666	6
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.666	4
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.666	4
UniProt:Q9HAC8 UBTD1			0.666	8
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.666	4
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.666	4
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.666	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.623	2
UniProt:Q9Y508 RNF114	1	RNF114 [cytosol] (R-HSA-8850894)	0.621	3
UniProt:Q8N5U6 RNF10			0.621	3
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.618	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.611	4
UniProt:Q68DV7 RNF43	10	RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs41 [plasma membrane] (R-HSA-9666643) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 R132 [plasma membrane] (R-HSA-9666650) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 E174* [plasma membrane] (R-HSA-5340574)	0.592	2
UniProt:Q96CA5-1 BIRC7			0.591	5
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.558	2
UniProt:Q99PZ6 OSPG			0.558	3
UniProt:O95155-1 UBE4B			0.558	2
UniProt:Q13191-1 CBLB			0.558	2
UniProt:O15151 MDM4	5	MDM4 [nucleoplasm] (R-HSA-349430) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502)	0.558	2
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q9HCM9-2 TRIM39			0.556	5
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q96B67 ARRD3			0.556	5
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
IntAct:EBI-22462114 CCSB ORF ID			0.556	5
UniProt:Q9NWM3 CUED1			0.556	3
UniProt:Q9BWX1 PHF7			0.556	3
UniProt:Q96EP1-2 CHFR			0.556	3
UniProt:Q6PCD5 RFWD3			0.553	2
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.553	2
UniProt:Q9BY78 RNF26			0.553	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.553	2
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.553	2
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.527	2
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.525	2
UniProt:Q96EP1 CHFR			0.488	2
UniProt:Q9NZS9 BFAR			0.488	2
UniProt:Q86Y13 DZIP3	1	DZIP3 [cytosol] (R-HSA-976002)	0.488	2
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.488	2

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