Reactome | Transmembrane protein gp41 [viral envelope]

Transmembrane protein gp41 [viral envelope]

Stable Identifier

R-HIV-171195

Type

Protein [EntityWithAccessionedSequence]

Species

Human immunodeficiency virus 1

Compartment

viral envelope

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Binding and entry of HIV virion (Homo sapiens)
        
        Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
        
        Mature HIV virion [extracellular region] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
        
        CD4:gp120:gp41 membrane complex [plasma membrane] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120 with exposed coreceptor binding site [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(exposed) [plasma membrane] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
        
        CD4:Env gp120 with exposed coreceptor binding site [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(exposed) [plasma membrane] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Conformational change in gp120 of Env oligomer (Homo sapiens)
        
        Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
        
        CD4:gp120:gp41 membrane complex [plasma membrane] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
        
        CD4:Env gp120 with exposed coreceptor binding site [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(exposed) [plasma membrane] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Conformational changes in gp120 exposes gp41 (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120 with exposed coreceptor binding site [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(exposed) [plasma membrane] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(second conformation change) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Fusion of viral membrane with host cell membrane (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41 hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41 hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Fusogenic activation of gp41 (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41(fusion peptide)/gp120(released) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with exposed fusion peptide [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp120(second conformation change) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41(fusion peptide)/gp120(released) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with exposed fusion peptide [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 insertion complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41(inserted)/gp120(released) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with fusion peptide inserted into membrane [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41 hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with hairpin structure formation [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CD4:Env gp120/gp41 insertion complex [plasma membrane] (Homo sapiens)
        
        Env oligomer with gp41(inserted)/gp120(released) [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer with fusion peptide inserted into membrane [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Budding and maturation of HIV virion (Homo sapiens)
        
        HIV Virion Budding (Homo sapiens)
        
        Immature HIV virion [extracellular region] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Maturation of HIV Virion (Homo sapiens)
        
        Immature HIV virion [extracellular region] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)
        
        Mature HIV virion [extracellular region] (Homo sapiens)
        
        Trimeric gp120:gp41 oligomer [viral envelope] (Human immunodeficiency virus 1)
        
        gp41 homotrimer [viral envelope] (Human immunodeficiency virus 1)
        
        Transmembrane protein gp41 [viral envelope] (Human immunodeficiency virus 1)

External Reference Information

External Reference

UniProt:P04578 env

Gene Names

env

Chain

signal peptide:1-32, chain:33-856, chain:33-511, chain:512-856

Reference Genes

BioGPS Gene:155971 env

KEGG:vg:155971 env

Monarch:155971 env

NCBI Gene:155971 env

UCSC:P04578 env

Reference Transcript

RefSeq:NC_001802.1 env

Participates

as a component of

Other forms of this molecule

ENV [viral envelope]

Surface protein gp120 [viral envelope]

Envelope glycoprotein gp160 [endoplasmic reticulum membrane]

Glycosylated Envelope glycoprotein gp160 [Golgi membrane]

Transmembrane protein gp41 (P04578) [cytosol]

Surface protein gp120 (P04578) [cytosol]

Cross References

RefSeq

NP_057856.1

ZINC - Substances

ENV_HV1H2

ZINC target

P04578

PRO

P04578

ZINC - Predictions - Purchasable

ENV_HV1H2

PDB

6UJV, 7EKK, 8F3B, 5YB2, 7R73, 6JQK, 6O3G, 6BXP, 1K33, 5ZCX, 1GZL, 3VIE, 1AIK, 5CIL, 5IVX, 4ZTO, 8B6Y, 6MQE, 3D0V, 2CMR, 6MQR, 5NVP, 8TQ8, 3TYG, 6SNC, 6PDS, 7LOI, 3J70, 5YC0, 1GC1, 6UJU, 5CN0, 3MNZ, 7RDW, 4YDV, 2XRA, 5BN0, 6N16, 6O42, 2MG3, 8FZ2, 5GHW, 5C0R, 6PSA, 1MZI, 7FF1, 2NY7, 6UCE, 5TKK, 6MQM, 1FAV, 5KA6, 1DF5, 6RYF, 4JPK, 7R74, 7N08, 3IDX, 6DLN, 6P8D, 5YB4, 7EKB, 7AEJ, 6BXQ, 6KTS, 8F3A, 3DNO, 6PDU, 1G9M, 2MG2, 6NCP, 2PV6, 5NWW, 5CMZ, 6WWC, 1RZJ, 5TKJ, 8TQ9, 5CIN, 6SNE, 1DF4, 5Z0W, 6P7H, 2ME1, 6PDR, 6O3J, 6DE7, 3DNN, 3IDY, 6UCF, 4JPJ, 6UBI, 6B9K, 5YB3, 6P60, 5WDF, 1K34, 3DNL, 1DLB, 6PEF, 2MG1, 5C0S, 5CMU, 6NPR, 5HM1, 3DRO, 8FYM, 5NWU, 6MQS, 5HFL, 8TQ7, 5DD0, 5KA5, 6MQC, 6SND, 6O3L, 6PEC, 7LOH, 5X08, 6J5E, 7N05, 5H0N

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.623	3
UniProt:Q9ULD8 KCNH3	1	KCNH3 [plasma membrane] (R-HSA-977527)	0.591	3
UniProt:P01730 CD4	4	CD4 [plasma membrane] (R-HSA-167542) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [early endosome] (R-HSA-182147) CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082)	0.558	2
UniProt:Q15165 PON2	1	PON2 [extracellular region] (R-HSA-8932636)	0.462	2
UniProt:Q9NWW5 CLN6			0.462	2
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.462	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.462	2
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342)	0.462	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.462	3
UniProt:P20701 ITGAL	2	ITGAL [plasma membrane] (R-HSA-198013) ITGAL [specific granule membrane] (R-HSA-6799536)	0.462	2
UniProt:Q6DD88 ATLA3			0.462	2
UniProt:Q9HCN8 SDF2L			0.462	4
UniProt:P49257 LMAN1	4	LMAN1 [Golgi membrane] (R-HSA-9715113) LMAN1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689821) LMAN1 [ER to Golgi transport vesicle membrane] (R-HSA-1017222) LMAN1 [endoplasmic reticulum membrane] (R-HSA-5689463)	0.462	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.462	2
UniProt:P43630 KIR3DL2	1	KIR3DL2 [plasma membrane] (R-HSA-197713)	0.462	2
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.462	4
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.462	4
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.462	2
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.462	2
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.462	2
UniProt:Q9H3P7 ACBD3	1	ACBD3 [Golgi membrane] (R-HSA-8874981)	0.462	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.462	4
UniProt:Q9BYC5 FUT8	1	FUT8 [Golgi membrane] (R-HSA-1028782)	0.462	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.462	4
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.462	2
UniProt:P01733 TRBV12-3	1	TRBV12-3 [plasma membrane] (R-HSA-198181)	0.462	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.462	2
UniProt:Q14696 MESD			0.462	2
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.462	2
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.462	4
UniProt:Q96IV0 NGLY1	1	NGLY1 [cytosol] (R-HSA-8850591)	0.462	2
UniProt:P01850 TRBC1	1	TRBC1 [plasma membrane] (R-HSA-198188)	0.462	2
UniProt:Q9BXS5 AP1M1	7	AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.462	2
UniProt:Q99470 SDF2			0.462	4
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.462	3
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.462	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.462	2
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.462	2
UniProt:Q96EE3 SEH1L	1	SEH1L [lysosomal membrane] (R-HSA-9638217)	0.462	2
UniProt:Q9Y282 ERGI3			0.462	2
UniProt:P14314 PRKCSH	3	PRKCSH [plasma membrane] (R-HSA-879405) p-PRKCSH [endoplasmic reticulum lumen] (R-HSA-8956890) PRKCSH [endoplasmic reticulum lumen] (R-HSA-532666)	0.462	4
UniProt:Q13112 CAF1B			0.462	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.462	2
UniProt:Q8TCT9 HM13	1	HM13 [endoplasmic reticulum membrane] (R-HSA-9708544)	0.462	2
UniProt:Q9NYU2 UGGT1	1	UGGT1 [endoplasmic reticulum lumen] (R-HSA-548864)	0.462	2
UniProt:Q96DZ1 ERLEC1	1	ERLEC1 [endoplasmic reticulum quality control compartment] (R-HSA-5362354)	0.462	3
UniProt:P07339 CTSD	12	CTSD(65-412) [extracellular region] (R-HSA-2990853) CTSD(65-412) [plasma membrane] (R-HSA-2990852) CTSD(169-412) [endosome lumen] (R-HSA-9816128) CTSD(65-161) [endosome lumen] (R-HSA-9816123) CTSD(65-412) [specific granule lumen] (R-HSA-6801272) CTSD(65-412) [tertiary granule lumen] (R-HSA-6801276) CTSD(65-412) [ficolin-1-rich granule lumen] (R-HSA-6801321) CTSD(169-412) [extracellular region] (R-HSA-2471614) CTSD(65-161) [extracellular region] (R-HSA-2228718) CTSD(65-412) [lysosomal lumen] (R-HSA-1181223) CTSD(169-412) [lysosomal lumen] (R-HSA-9023737) CTSD(65-161) [lysosomal lumen] (R-HSA-9023739)	0.462	2
UniProt:P51571 SSR4	1	SSR4 [endoplasmic reticulum membrane] (R-HSA-265026)	0.462	2
UniProt:O14967 CLGN			0.462	2

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