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p-T183,Y185-MAPK12 [cytosol]
Stable Identifier
R-HSA-171021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-MAP kinase p38 gamma, P-MAPK12
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Activation of p38 alpha/beta MAPK (Homo sapiens)
pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
Nuclear translocation of p38 MAPK (Homo sapiens)
pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activation of p38 MAPK (Homo sapiens)
Phospho-p38 MAPK [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
MAPK12 phosphorylates PTPN3 (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53778 MAPK12
Gene Names
MAPK12, ERK6, SAPK3
Chain
chain:1-367
Reference Genes
BioGPS Gene:6300 MAPK12
COSMIC (genes):MAPK12 MAPK12
CTD Gene:6300 MAPK12
dbSNP Gene:6300 MAPK12
ENSEMBL:ENSG00000188130 MAPK12
ENSEMBL:ENSG00000188130.14 MAPK12
HGNC:6874 MAPK12
KEGG Gene (Homo sapiens):6300 MAPK12
Monarch:6300 MAPK12
NCBI Gene:6300 MAPK12
OMIM:602399 MAPK12
UCSC:P53778 MAPK12
Reference Transcript
RefSeq:NM_001303252.2 MAPK12
RefSeq:NM_002969.5 MAPK12
Other Identifiers
11742969_a_at
11746262_a_at
16936408
206106_PM_at
206106_at
3965752
3965753
3965758
3965760
3965761
3965762
3965765
3965768
3965769
3965771
3965773
3965774
3965776
3965778
3965779
3965780
3965781
6300
8076962
984_g_at
A_33_P3763846
GE62595
GO:0000165
GO:0000166
GO:0000287
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006468
GO:0007049
GO:0007165
GO:0007517
GO:0010952
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0030154
GO:0035556
GO:0036211
GO:0042770
GO:0043226
GO:0045445
GO:0045786
GO:0046872
GO:0048856
GO:0051149
GO:0051726
GO:0106310
GO:0140096
HMNXSV003008606
HMNXSV003054496
Hs.55039.0.S2_3p_at
Hs.55039.0.S2_3p_x_at
ILMN_1797786
PH_hs_0020025
X79483_at
Participates
as a member of
Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
as a component of
p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
PTPN3:p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)
as an input of
PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)
as a candidate of
Phospho-p38 MAPK [cytosol] (Homo sapiens)
Other forms of this molecule
MAPK12 [cytosol]
MAPK12 [nucleoplasm]
Inferred To
phospho-MAPK12 [cytosol]
(Bos taurus)
phospho-MAPK12 [cytosol]
(Gallus gallus)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Caenorhabditis elegans)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Canis familiaris)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Danio rerio)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Drosophila melanogaster)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Mus musculus)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Rattus norvegicus)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Sus scrofa)
phospho-p-T183,Y185-MAPK12 [cytosol]
(Xenopus tropicalis)
Homologues of p-T183,Y185-MAPK12 [cytosol]
(Caenorhabditis elegans)
Homologues of p-T183,Y185-MAPK12 [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 183
Coordinate
183
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 185
Coordinate
185
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002960.2
,
NP_001290181.1
ZINC - World Drugs
MK12_HUMAN
Guide to Pharmacology - Targets
1501
OpenTargets
ENSG00000188130
ZINC - FDA approved
MK12_HUMAN
ZINC - Substances
MK12_HUMAN
ZINC target
P53778
ZINC - Biogenic
MK12_HUMAN
PRO
P53778
PDB
7CGA
,
4QUM
,
1CM8
,
6UNA
ZINC - Investigational
MK12_HUMAN
IntEnz
2.7.11.24
HPA
ENSG00000188130-MAPK12
GeneCards
P53778
Ensembl
ENSP00000479972
,
ENST00000622558
,
ENSP00000215659
,
ENSG00000188130
,
ENST00000215659
Pharos - Targets
P53778
ZINC - Predictions - Purchasable
MK12_HUMAN
HMDB Protein
HMDBP01135
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.72
6
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [plasma membrane]
(R-HSA-375977)
0.571
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
3
UniProt:O15264 MAPK13
2
p-T180,Y182-MAPK13 [cytosol]
(R-HSA-171022)
MAPK13 [cytosol]
(R-HSA-171012)
0.527
2
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