Reactome | p-T183,Y185-MAPK12 [cytosol]

p-T183,Y185-MAPK12 [cytosol]

Stable Identifier

R-HSA-171021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-MAP kinase p38 gamma, P-MAPK12

Icon

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
    - NOD1/2 Signaling Pathway (Homo sapiens)
      - Activation of p38 MAPK (Homo sapiens)
        
        Phospho-p38 MAPK [cytosol] (Homo sapiens)
        
        p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53778 MAPK12

Gene Names

MAPK12, ERK6, SAPK3

Chain

chain:1-367

Reference Genes

BioGPS Gene:6300 MAPK12

COSMIC (genes):MAPK12 MAPK12

CTD Gene:6300 MAPK12

dbSNP Gene:6300 MAPK12

ENSEMBL:ENSG00000188130 MAPK12

HGNC:6874 MAPK12

KEGG:hsa:6300 MAPK12

Monarch:6300 MAPK12

NCBI Gene:6300 MAPK12

OMIM:602399 MAPK12

UCSC:P53778 MAPK12

Reference Transcript

Other Identifiers

11724583_a_at

11742969_a_at

11746262_a_at

11760337_a_at

1556340_PM_at

1556340_at

1556341_PM_s_at

1556341_s_at

16936360

16936397

16936408

206106_PM_at

206106_at

226672_PM_s_at

226672_s_at

3965696

3965698

3965699

3965703

3965704

3965708

3965710

3965712

3965714

3965715

3965716

3965718

3965720

3965723

3965725

3965726

3965729

3965730

3965731

3965733

3965734

3965735

3965736

3965737

3965738

3965739

3965740

3965741

3965742

3965743

3965744

3965745

3965747

3965749

3965750

3965752

3965753

3965754

3965755

3965756

3965757

3965758

3965760

3965761

3965762

3965763

3965764

3965765

3965766

3965767

3965768

3965769

3965770

3965771

3965772

3965773

3965774

3965775

3965776

3965777

3965778

3965779

3965780

3965781

51132_at

6300

8076937

8076962

984_g_at

A_23_P29347

A_23_P368740

A_33_P3250055

A_33_P3763846

GE62595

GE80761

GO:0000165

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006468

GO:0007165

GO:0007517

GO:0010952

GO:0016301

GO:0016740

GO:0018105

GO:0030154

GO:0035556

GO:0042770

GO:0043226

GO:0045445

GO:0045786

GO:0046872

GO:0048856

GO:0051149

GO:0051726

GO:0106310

GO:0140096

HMNXSV003008606

HMNXSV003022701

HMNXSV003031201

HMNXSV003054496

HMNXSV003054897

Hs.26593.0.S1_3p_a_at

Hs.55039.0.S2_3p_at

Hs.55039.0.S2_3p_x_at

Hs2.432642.1.S1_3p_s_at

ILMN_1797786

ILMN_2102787

PH_hs_0002346

PH_hs_0020025

PH_hs_0036362

TC22001497.hg

TC22001498.hg

X79483_at

Participates

as a member of

Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)

as a component of

as an input of

PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)

as a candidate of

Phospho-p38 MAPK [cytosol] (Homo sapiens)

Other forms of this molecule

MAPK12 [nucleoplasm]

MAPK12 [cytosol]

Inferred To

phospho-MAPK12 [cytosol] (Canis familiaris)

phospho-MAPK12 [cytosol] (Gallus gallus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Bos taurus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Caenorhabditis elegans)

phospho-p-T183,Y185-MAPK12 [cytosol] (Danio rerio)

phospho-p-T183,Y185-MAPK12 [cytosol] (Dictyostelium discoideum)

phospho-p-T183,Y185-MAPK12 [cytosol] (Drosophila melanogaster)

phospho-p-T183,Y185-MAPK12 [cytosol] (Mus musculus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Rattus norvegicus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T183,Y185-MAPK12 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T183,Y185-MAPK12 [cytosol] (Sus scrofa)

phospho-p-T183,Y185-MAPK12 [cytosol] (Xenopus tropicalis)

phospho-gskl-2 [cytosol] (Caenorhabditis elegans)

Homologues of p-T183,Y185-MAPK12 [cytosol] (Caenorhabditis elegans)

Homologues of p-T183,Y185-MAPK12 [cytosol] (Dictyostelium discoideum)

Homologues of p-T183,Y185-MAPK12 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 183

Coordinate

183

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 185

Coordinate

185

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Guide to Pharmacology - Targets

1501

ENSEMBL

ENST00000215659, ENSP00000215659, ENSG00000188130, ENSP00000479972, ENST00000622558

OpenTargets

ENSG00000188130

ZINC - FDA approved

MK12_HUMAN

ZINC - Substances

MK12_HUMAN

ZINC - Biogenic

MK12_HUMAN

ZINC target

P53778

PRO

P53778

PDB

1CM8, 4QUM, 7CGA, 6UNA

ZINC - Investigational

MK12_HUMAN

GeneCards

MAPK12

HPA

ENSG00000188130-MAPK12

Pharos - Targets

P53778

ZINC - Predictions - Purchasable

MK12_HUMAN

HMDB Protein

HMDBP01135

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.72	6
UniProt:O15264 MAPK13	2	p-T180,Y182-MAPK13 [cytosol] (R-HSA-171022) MAPK13 [cytosol] (R-HSA-171012)	0.643	4
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593)	0.571	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q32MK0 MYLK3			0.527	3