Reactome | p-T183,Y185-MAPK12 [cytosol]

p-T183,Y185-MAPK12 [cytosol]

Stable Identifier

R-HSA-171021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-MAP kinase p38 gamma, P-MAPK12

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Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
    - NOD1/2 Signaling Pathway (Homo sapiens)
      - Activation of p38 MAPK (Homo sapiens)
        
        Phospho-p38 MAPK [cytosol] (Homo sapiens)
        
        p-T183,Y185-MAPK12 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53778 MAPK12

Gene Names

MAPK12, ERK6, SAPK3

Chain

chain:1-367

Reference Genes

BioGPS Gene:6300 MAPK12

COSMIC (genes):MAPK12 MAPK12

CTD Gene:6300 MAPK12

dbSNP Gene:6300 MAPK12

ENSEMBL:ENSG00000188130 MAPK12

ENSEMBL:ENSG00000188130.14 MAPK12

HGNC:6874 MAPK12

KEGG Gene (Homo sapiens):6300 MAPK12

Monarch:6300 MAPK12

NCBI Gene:6300 MAPK12

OMIM:602399 MAPK12

UCSC:P53778 MAPK12

Reference Transcript

Other Identifiers

11742969_a_at

11746262_a_at

16936408

206106_PM_at

206106_at

3965752

3965753

3965758

3965760

3965761

3965762

3965765

3965768

3965769

3965771

3965773

3965774

3965776

3965778

3965779

3965780

3965781

6300

8076962

984_g_at

A_33_P3763846

GE62595

GO:0000165

GO:0000166

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006468

GO:0007049

GO:0007165

GO:0007517

GO:0010952

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0030154

GO:0035556

GO:0036211

GO:0042770

GO:0043226

GO:0045445

GO:0045786

GO:0046872

GO:0048856

GO:0051149

GO:0051726

GO:0106310

GO:0140096

HMNXSV003008606

HMNXSV003054496

Hs.55039.0.S2_3p_at

Hs.55039.0.S2_3p_x_at

ILMN_1797786

PH_hs_0020025

X79483_at

Participates

as a member of

Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)

as a component of

as an input of

PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)

as a candidate of

Phospho-p38 MAPK [cytosol] (Homo sapiens)

Other forms of this molecule

MAPK12 [cytosol]

MAPK12 [nucleoplasm]

Inferred To

phospho-MAPK12 [cytosol] (Bos taurus)

phospho-MAPK12 [cytosol] (Gallus gallus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Caenorhabditis elegans)

phospho-p-T183,Y185-MAPK12 [cytosol] (Canis familiaris)

phospho-p-T183,Y185-MAPK12 [cytosol] (Danio rerio)

phospho-p-T183,Y185-MAPK12 [cytosol] (Drosophila melanogaster)

phospho-p-T183,Y185-MAPK12 [cytosol] (Mus musculus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Rattus norvegicus)

phospho-p-T183,Y185-MAPK12 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T183,Y185-MAPK12 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T183,Y185-MAPK12 [cytosol] (Sus scrofa)

phospho-p-T183,Y185-MAPK12 [cytosol] (Xenopus tropicalis)

Homologues of p-T183,Y185-MAPK12 [cytosol] (Caenorhabditis elegans)

Homologues of p-T183,Y185-MAPK12 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 183

Coordinate

183

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 185

Coordinate

185

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002960.2, NP_001290181.1

ZINC - World Drugs

MK12_HUMAN

Guide to Pharmacology - Targets

1501

OpenTargets

ENSG00000188130

ZINC - FDA approved

MK12_HUMAN

ZINC - Substances

MK12_HUMAN

ZINC target

P53778

ZINC - Biogenic

MK12_HUMAN

PRO

P53778

PDB

7CGA, 4QUM, 1CM8, 6UNA

ZINC - Investigational

MK12_HUMAN

IntEnz

2.7.11.24

HPA

ENSG00000188130-MAPK12

GeneCards

P53778

Ensembl

ENSP00000479972, ENST00000622558, ENSP00000215659, ENSG00000188130, ENST00000215659

Pharos - Targets

P53778

ZINC - Predictions - Purchasable

MK12_HUMAN

HMDB Protein

HMDBP01135

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.72	6
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [cytosol] (R-HSA-416332) DLG1 [plasma membrane] (R-HSA-375977)	0.571	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:O15264 MAPK13	2	p-T180,Y182-MAPK13 [cytosol] (R-HSA-171022) MAPK13 [cytosol] (R-HSA-171012)	0.527	2

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