Reactome | IDE [endosome lumen]

IDE [endosome lumen]

Stable Identifier

R-HSA-9794504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome lumen

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - Insulin degradation (Homo sapiens)
        
        IDE, CTSD [endosome lumen] (Homo sapiens)
        
        IDE dimer [endosome lumen] (Homo sapiens)
        
        IDE:Zn++ [endosome lumen] (Homo sapiens)
        
        IDE [endosome lumen] (Homo sapiens)
        
        IDE:Zn++ [endosome lumen] (Homo sapiens)
        
        IDE [endosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

BioGPS Gene:3416 IDE

COSMIC (genes):IDE IDE

CTD Gene:3416 IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

HGNC:5381 IDE

KEGG:hsa:3416 IDE

Monarch:3416 IDE

NCBI Gene:3416 IDE

OMIM:146680 IDE

UCSC:P14735 IDE

Reference Transcript

Participates

as a component of

IDE:Zn++ [endosome lumen] (Homo sapiens)

Other forms of this molecule

IDE [cytosol]

IDE [peroxisomal matrix]

PolyUb-IDE [mitochondrial outer membrane]

IDE [mitochondrial outer membrane]

Inferred To

IDE [endosome lumen] (Bos taurus)

IDE [endosome lumen] (Canis familiaris)

IDE [endosome lumen] (Gallus gallus)

IDE [endosome lumen] (Sus scrofa)

ide [endosome lumen] (Danio rerio)

ide [endosome lumen] (Xenopus tropicalis)

Ide [endosome lumen] (Mus musculus)

Ide [endosome lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_004960.2, NP_001159418.1

Guide to Pharmacology - Targets

2371

OpenTargets

ENSG00000119912

ENSEMBL

ENST00000371581, ENSP00000265986, ENST00000265986, ENSP00000360637, ENSG00000119912

ZINC - Substances

IDE_HUMAN

ZINC target

P14735

PRO

P14735

GlyGen

P14735

PDB

4DTT, 3E4Z, 4DWK, 4LTE, 5WOB, 6MQ3, 3N57, 7RZG, 2WC0, 5UOE, 6BYZ, 2G47, 2G48, 2WBY, 4QIA, 7RZF, 6BF6, 4RAL, 3E4A, 6B3Q, 3OFI, 6B7Y, 6B7Z, 4PFC, 3HGZ, 4GSC, 7K1E, 6B70, 2YPU, 2G56, 4GSF, 4RE9, 3E50, 6BFC, 4NXO, 7RZI, 7RZH, 4M1C, 7RZE, 4GS8, 6EDS, 3QZ2, 4IFH, 5CJO, 2WK3, 2G49, 6BF7, 6BF9, 3N56, 6BF8, 4PES, 3CWW, 4PF7, 4PF9, 2JG4, 7K1F, 4IOF, 7K1D, 2JBU, 2G54, 3H44

HPA

ENSG00000119912-IDE

GeneCards

IDE

Pharos - Targets

P14735

ZINC - Predictions - Purchasable

IDE_HUMAN

HMDB Protein

HMDBP10019

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.643	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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