Reactome | CHRNA7 [plasma membrane]

CHRNA7 [plasma membrane]

Stable Identifier

R-HSA-507830

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-7, ACHA7_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36544 CHRNA7

Gene Names

CHRNA7, NACHRA7

Chain

signal peptide:1-22, chain:23-502

Reference Genes

BioGPS Gene:1139 CHRNA7

BioGPS Gene:89832 CHRNA7

COSMIC (genes):CHRNA7 CHRNA7

CTD Gene:1139 CHRNA7

CTD Gene:89832 CHRNA7

dbSNP Gene:1139 CHRNA7

dbSNP Gene:89832 CHRNA7

ENSEMBL:ENSG00000175344.19 CHRNA7

HGNC:1960 CHRNA7

KEGG Gene (Homo sapiens):1139 CHRNA7

Monarch:1139 CHRNA7

Monarch:89832 CHRNA7

NCBI Gene:1139 CHRNA7

NCBI Gene:89832 CHRNA7

OMIM:118511 CHRNA7

UCSC:P36544 CHRNA7

Reference Transcript

Other Identifiers

0004210114

0006040114

1139

11739850_s_at

11740008_s_at

11740009_a_at

11750964_s_at

16798765

210123_PM_s_at

210123_s_at

236385_PM_at

236385_at

3587230

3587231

3587232

3587240

3587242

3587250

3587252

3587253

3587254

3587256

3587257

3587259

3587260

3587261

3587262

3587271

3587273

3587274

3615785

3615786

3615788

3615790

3615792

3615793

3615795

3615796

3615798

3615799

3615800

3615802

39566_at

69847_at

7982341

7987012

80966_at

A_23_P163390

A_32_P35969

A_33_P3313519

A_33_P3719083

GE80948

GO:0001540

GO:0001666

GO:0001934

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005231

GO:0005262

GO:0005515

GO:0005886

GO:0005887

GO:0005892

GO:0006811

GO:0006816

GO:0006874

GO:0007165

GO:0007268

GO:0007271

GO:0007611

GO:0007613

GO:0007614

GO:0008284

GO:0015464

GO:0015643

GO:0016020

GO:0016021

GO:0017081

GO:0022848

GO:0023052

GO:0030154

GO:0030594

GO:0032720

GO:0032991

GO:0034220

GO:0034330

GO:0035094

GO:0036211

GO:0042166

GO:0042391

GO:0042803

GO:0043005

GO:0043410

GO:0044853

GO:0045202

GO:0045211

GO:0045766

GO:0048856

GO:0050808

GO:0050877

GO:0050890

GO:0050893

GO:0051247

GO:0055065

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0070374

GO:0070588

GO:0095500

GO:0097061

GO:0098772

GO:0098794

GO:0098815

GO:0110165

GO:0140059

GO:1900273

GO:1901214

GO:1902004

GO:1902430

GO:1902991

GO:1904315

GO:1904645

GO:1905144

GO:1905906

GO:1905920

GO:2000463

HMNXSV003024178

Hs.207457.0.A1_3p_at

ILMN_1676826

ILMN_1683373

ILMN_1788789

ILMN_1791501

ILMN_1845868

ILMN_3237574

PH_hs_0027395

PH_hs_0040493

TC15002129.hg

TC15002755.hg

X70297_at

g1458119_3p_a_at

p5075

Participates

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

as a component of

Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)

Inferred To

acr-25 [plasma membrane] (Caenorhabditis elegans)

acr-19 [plasma membrane] (Caenorhabditis elegans)

lgc-26 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha6 [plasma membrane] (Drosophila melanogaster)

acr-16 [plasma membrane] (Caenorhabditis elegans)

LOC101882451 [plasma membrane] (Danio rerio)

lgc-25 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha5 [plasma membrane] (Drosophila melanogaster)

acr-15 [plasma membrane] (Caenorhabditis elegans)

Chrna7 [plasma membrane] (Mus musculus)

Chrna7 [plasma membrane] (Rattus norvegicus)

Homologues of CHRNA7 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA7 [plasma membrane] (Drosophila melanogaster)

eat-2 [plasma membrane] (Caenorhabditis elegans)

acr-10 [plasma membrane] (Caenorhabditis elegans)

acr-9 [plasma membrane] (Caenorhabditis elegans)

CHRNA7 [plasma membrane] (Bos taurus)

CHRNA7 [plasma membrane] (Canis familiaris)

CHRNA7 [plasma membrane] (Gallus gallus)

CHRNA7 [plasma membrane] (Sus scrofa)

nAChRalpha7 [plasma membrane] (Drosophila melanogaster)

acr-14 [plasma membrane] (Caenorhabditis elegans)

acr-7 [plasma membrane] (Caenorhabditis elegans)

chrna7 [plasma membrane] (Xenopus tropicalis)

acr-11 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000737.1, NP_683709.1, NP_001177384.1, XP_005254807.1, XP_016877373.1

ZINC - World Drugs

ACHA7_HUMAN

Guide to Pharmacology - Targets

468

OpenTargets

ENSG00000175344

ZINC - FDA approved

ACHA7_HUMAN

ZINC - Substances

ACHA7_HUMAN

ZINC - Biogenic

ACHA7_HUMAN

ZINC target

P36544

PRO

P36544

PDB

5AFL, 7EKT, 7EKP, 7RPM, 7KOX, 5AFK, 5AFN, 7EKI, 5AFJ, 7KOQ, 5AFM, 5AFH, 2MAW, 7KOO

ZINC - Investigational

ACHA7_HUMAN

ZINC - Metabolites

ACHA7_HUMAN

HPA

ENSG00000175344-CHRNA7

GeneCards

P36544

Ensembl

ENSP00000399087, ENSG00000175344, ENST00000306901, ENST00000437966, ENSP00000407546, ENST00000454250, ENSP00000303727, ENSP00000502560, ENST00000675428

Pharos - Targets

P36544

ZINC - Predictions - Purchasable

ACHA7_HUMAN

Orphanet

20105

HMDB Protein

HMDBP12048

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.646	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3