Reactome | PRKACB [cytosol]

PRKACB [cytosol]

Stable Identifier

R-HSA-57846

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase, beta-catalytic subunit , PKA C-beta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22694 PRKACB

Gene Names

PRKACB

Chain

initiator methionine:1, chain:2-351

Reference Genes

BioGPS Gene:5567 PRKACB

COSMIC (genes):PRKACB PRKACB

CTD Gene:5567 PRKACB

dbSNP Gene:5567 PRKACB

ENSEMBL:ENSG00000142875 PRKACB

HGNC:9381 PRKACB

KEGG:hsa:5567 PRKACB

Monarch:5567 PRKACB

NCBI Gene:5567 PRKACB

OMIM:176892 PRKACB

UCSC:P22694 PRKACB

Reference Transcript

Participates

as a candidate of

Protein kinase A catalytic subunit [cytosol] (Homo sapiens)

as a member of

PKA catalytic subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKACB [nucleoplasm]

PRKACB [ciliary base]

Inferred To

pkgD [cytosol] (Dictyostelium discoideum)

TPK3 [cytosol] (Saccharomyces cerevisiae)

Pka-C1 [cytosol] (Drosophila melanogaster)

TPK2 [cytosol] (Saccharomyces cerevisiae)

prkacba [cytosol] (Danio rerio)

pka1 [cytosol] (Schizosaccharomyces pombe)

kin-1 [cytosol] (Caenorhabditis elegans)

PRKACB [cytosol] (Gallus gallus)

TPK1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKACA [cytosol] (Dictyostelium discoideum)

Homologues of PRKACA [cytosol] (Plasmodium falciparum)

pkaD [cytosol] (Dictyostelium discoideum)

Dmel\CG12069 [cytosol] (Drosophila melanogaster)

Homologues of PRKACB [cytosol] (Drosophila melanogaster)

Homologues of PRKACB [cytosol] (Saccharomyces cerevisiae)

PKG [cytosol] (Plasmodium falciparum)

pkaC [cytosol] (Dictyostelium discoideum)

PRKACA [cytosol] (Plasmodium falciparum)

Pka-C2 [cytosol] (Drosophila melanogaster)

Prkacb [cytosol] (Mus musculus)

Prkacb [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001229790.1, NP_001229791.1, NP_002722.1, NP_891993.1, NP_001287844.1, NP_001287845.1, NP_001229786.1, NP_001287846.1, NP_001229787.1, NP_001229788.1, NP_001229789.1, NP_997461.1, NP_001362494.1, XP_005271076.1, NP_001362489.1, XP_006710821.1

ZINC - World Drugs

KAPCB_HUMAN

Guide to Pharmacology - Targets

1477

OpenTargets

ENSG00000142875

ENSEMBL

ENST00000370688, ENSP00000479722, ENSP00000401252, ENST00000436133, ENSP00000390906, ENSG00000142875, ENSP00000359722, ENSP00000378315, ENSP00000359723, ENST00000446538, ENST00000394839, ENSP00000359719, ENST00000614872, ENST00000370689, ENSP00000481980, ENST00000610703, ENST00000370685

ZINC - FDA approved

KAPCB_HUMAN

ZINC - Substances

KAPCB_HUMAN

ZINC - Biogenic

KAPCB_HUMAN

ZINC target

P22694

PRO

P22694

GlyGen

P22694

ZINC - Investigational

KAPCB_HUMAN

HPA

ENSG00000142875-PRKACB

GeneCards

PRKACB

Pharos - Targets

P22694

ZINC - Predictions - Purchasable

KAPCB_HUMAN

HMDB Protein

HMDBP01415

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.788	8
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.725	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.725	5
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.643	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8N6U8 GPR161	2	GPR161 [ciliary membrane] (R-HSA-5610373) GPR161 [endocytic vesicle membrane] (R-HSA-5635021)	0.527	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2