Reactome | TGFB2 [extracellular region]

TGFB2 [extracellular region]

Stable Identifier

R-HSA-114706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

TGF-beta-2, Transforming growth factor beta 2 precursor, Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin

Icon

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        TGF beta [extracellular region] (Homo sapiens)
        
        TGFB2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61812 TGFB2

Gene Names

TGFB2

Chain

signal peptide:1-20, chain:21-414, chain:21-302, chain:303-414

Reference Genes

BioGPS Gene:7042 TGFB2

COSMIC (genes):TGFB2 TGFB2

CTD Gene:7042 TGFB2

dbSNP Gene:7042 TGFB2

ENSEMBL:ENSG00000092969 TGFB2

ENSEMBL_homo_sapiens_GENE:ENSG00000092969.12 TGFB2

HGNC:11768 TGFB2

KEGG Gene (Homo sapiens):7042 TGFB2

Monarch:7042 TGFB2

NCBI Gene:7042 TGFB2

OMIM:190220 TGFB2

UCSC:P61812 TGFB2

Reference Transcript

Other Identifiers

11736553_a_at

11740596_a_at

1262_s_at

16677556

209908_PM_s_at

209908_s_at

209909_PM_s_at

209909_s_at

220407_PM_s_at

220407_s_at

228121_PM_at

228121_at

2380596

2380597

2380598

2380599

2380600

2380601

2380610

2380623

2380624

2380629

2380632

2380633

2380634

2380636

2380637

2380638

2380639

52622_at

7042

7909789

971_s_at

A_14_P117884

A_14_P120374

A_24_P148261

A_24_P402438

GE81250

GO:0000902

GO:0001501

GO:0001540

GO:0001654

GO:0001666

GO:0001822

GO:0001837

GO:0001843

GO:0001942

GO:0002376

GO:0003007

GO:0003013

GO:0003148

GO:0003149

GO:0003179

GO:0003181

GO:0003184

GO:0003203

GO:0003215

GO:0003222

GO:0003274

GO:0003289

GO:0003407

GO:0005102

GO:0005114

GO:0005125

GO:0005160

GO:0005515

GO:0005576

GO:0005615

GO:0006351

GO:0006355

GO:0007155

GO:0007179

GO:0007435

GO:0007507

GO:0008083

GO:0008284

GO:0008285

GO:0008347

GO:0008584

GO:0009611

GO:0009790

GO:0009792

GO:0009888

GO:0010002

GO:0010629

GO:0010634

GO:0010718

GO:0010936

GO:0012501

GO:0016477

GO:0016525

GO:0022414

GO:0023052

GO:0030097

GO:0030154

GO:0030198

GO:0030199

GO:0030307

GO:0030308

GO:0030312

GO:0030326

GO:0030424

GO:0030593

GO:0030855

GO:0031012

GO:0031069

GO:0031093

GO:0031410

GO:0032147

GO:0032570

GO:0032874

GO:0032909

GO:0033630

GO:0034330

GO:0034714

GO:0035910

GO:0036211

GO:0042060

GO:0042127

GO:0042416

GO:0042476

GO:0042704

GO:0042803

GO:0043025

GO:0043226

GO:0043525

GO:0045216

GO:0045726

GO:0045747

GO:0045787

GO:0045823

GO:0046580

GO:0048018

GO:0048103

GO:0048566

GO:0048666

GO:0048699

GO:0048839

GO:0048856

GO:0048870

GO:0050680

GO:0050714

GO:0050778

GO:0050896

GO:0051781

GO:0051794

GO:0051795

GO:0051891

GO:0051897

GO:0060038

GO:0060065

GO:0060317

GO:0060391

GO:0060412

GO:0060413

GO:0061024

GO:0061626

GO:0062009

GO:0062023

GO:0097191

GO:0098772

GO:1902256

GO:1902895

GO:1903701

GO:1904888

GO:1905006

GO:1905007

HMNXSV003008509

HMNXSV003016293

Hs.169300.1.S1_3p_a_at

Hs.23837.0.A1_3p_at

ILMN_1812526

M19154_at

PH_hs_0010095

TC01001805.hg

Y00083_s_at

g339549_3p_a_at

g4507462_3p_a_at

Participates

as a member of

as a component of

TGFB2:LAP2 [extracellular region] (Homo sapiens)

Other forms of this molecule

TGFB2 [platelet alpha granule lumen]

TGFB2(20-302) [extracellular region]

Inferred To

TGFB2 [extracellular region] (Bos taurus)

TGFB2 [extracellular region] (Canis familiaris)

TGFB2 [extracellular region] (Gallus gallus)

TGFB2 [extracellular region] (Sus scrofa)

mav [extracellular region] (Drosophila melanogaster)

Tgfb2 [extracellular region] (Mus musculus)

Tgfb2 [extracellular region] (Rattus norvegicus)

dbl-1 [extracellular region] (Caenorhabditis elegans)

daf-7 [extracellular region] (Caenorhabditis elegans)

tgfb2 [extracellular region] (Danio rerio)

tgfb2 [extracellular region] (Xenopus tropicalis)

Homologues of TGFB2 [extracellular region] (Caenorhabditis elegans)

Homologues of TGFB2 [extracellular region] (Drosophila melanogaster)

dpp [extracellular region] (Drosophila melanogaster)

unc-129 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003229.1, NP_001129071.1

OpenTargets

ENSG00000092969

HPA

ENSG00000092969-TGFB2

GeneCards

P61812

Ensembl

ENST00000366930, ENSG00000092969, ENSP00000355897, ENSP00000355896, ENST00000366929

PRO

P61812

Pharos - Targets

P61812

Orphanet

15607

HMDB Protein

HMDBP14497

PDB

8FXV, 8DC0, 5TY4, 4KXZ, 6I9J, 1TFG, 2TGI, 6XM2, 8FXS, 5TX4, 7RCO

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.705	7

Cite Us!