Reactome | p-S208-SMAD3 [cytosol]

p-S208-SMAD3 [cytosol]

Stable Identifier

R-HSA-9731114

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
        
        p-S250-SMAD2,p-S208-SMAD3 [cytosol] (Homo sapiens)
        
        p-S208-SMAD3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
        
        MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)
        
        p-S250-SMAD2,p-S208-SMAD3 [cytosol] (Homo sapiens)
        
        p-S208-SMAD3 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
10197981	A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras Doody, J, Kretzschmar, M, Massagué, J, Timokhina, I	Genes Dev	1999
16156666	Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3 Wang, G, He, D, Liu, F, Matsuura, I	Biochemistry	2005

External Reference Information

External Reference

UniProt:P84022 SMAD3

Gene Names

SMAD3, MADH3

Chain

initiator methionine:, chain:2-425

Reference Genes

BioGPS Gene:4088 SMAD3

COSMIC (genes):SMAD3 SMAD3

CTD Gene:4088 SMAD3

dbSNP Gene:4088 SMAD3

ENSEMBL:ENSG00000166949 SMAD3

HGNC:6769 SMAD3

KEGG:hsa:4088 SMAD3

Monarch:4088 SMAD3

NCBI Gene:4088 SMAD3

OMIM:603109 SMAD3

UCSC:P84022 SMAD3

Reference Transcript

Other Identifiers

11718265_a_at

11718266_s_at

11726549_a_at

11751185_a_at

11754091_s_at

1433_g_at

1454_at

1950_s_at

205396_PM_at

205396_at

205397_PM_x_at

205397_x_at

205398_PM_s_at

205398_s_at

218284_PM_at

218284_at

3598960

3598961

3598977

3598978

3598984

3598985

3598992

3598993

3598994

3598995

3598996

3598997

3598999

3599000

3599004

3599005

3599008

3599009

3599010

3599011

3599012

3599013

3599014

3599016

3599018

3599019

3599020

3599021

3599022

3599023

3599028

3599029

3599030

3599031

3599032

3599033

3599034

3599035

3599036

3599037

3599038

3599039

3599040

3599041

3599042

38944_at

4088

44841_at

44986_s_at

49922_at

51059_at

58763_at

65983_at

7984364

84945_at

A_14_P107358

A_23_P48936

GE56446

GE79350

GO:0000122

GO:0000165

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001217

GO:0001222

GO:0001223

GO:0001228

GO:0001501

GO:0001649

GO:0001657

GO:0001666

GO:0001701

GO:0001707

GO:0001756

GO:0001889

GO:0001947

GO:0002076

GO:0002376

GO:0002520

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005160

GO:0005515

GO:0005518

GO:0005634

GO:0005637

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006915

GO:0006919

GO:0006955

GO:0007179

GO:0007254

GO:0007369

GO:0007492

GO:0008013

GO:0008270

GO:0008283

GO:0008285

GO:0009653

GO:0009880

GO:0010468

GO:0010628

GO:0010629

GO:0010718

GO:0012501

GO:0016202

GO:0016922

GO:0017015

GO:0017151

GO:0019899

GO:0019901

GO:0019902

GO:0023019

GO:0030154

GO:0030308

GO:0030325

GO:0030335

GO:0030501

GO:0030878

GO:0031053

GO:0031490

GO:0031625

GO:0031962

GO:0032332

GO:0032731

GO:0032810

GO:0032909

GO:0032916

GO:0032924

GO:0033689

GO:0034330

GO:0035259

GO:0038092

GO:0042060

GO:0042110

GO:0042177

GO:0042307

GO:0042802

GO:0042803

GO:0043066

GO:0043130

GO:0043226

GO:0043235

GO:0043425

GO:0043565

GO:0045216

GO:0045429

GO:0045599

GO:0045668

GO:0045893

GO:0045944

GO:0046872

GO:0048340

GO:0048589

GO:0048617

GO:0048701

GO:0048856

GO:0050678

GO:0050728

GO:0050776

GO:0050821

GO:0050927

GO:0051091

GO:0051481

GO:0051496

GO:0051894

GO:0060039

GO:0060290

GO:0060395

GO:0061045

GO:0061629

GO:0061767

GO:0070306

GO:0070410

GO:0070411

GO:0070412

GO:0071141

GO:0071144

GO:0071333

GO:0071559

GO:0071560

GO:0090263

GO:0097191

GO:0098586

GO:0140110

GO:0140297

GO:1901203

GO:1902893

GO:1902894

GO:1902895

GO:1903243

GO:1990776

GO:1990841

HMNXSV003022522

Hs.211578.0.S3_3p_at

ILMN_1682738

PH_hs_0032513

PH_hs_0039929

TC15000622.hg

TC15002251.hg

U68019_at

g1673576_3p_s_at

g5174512_3p_s_at

g7661691_3p_at

Participates

as a member of

p-S250-SMAD2,p-S208-SMAD3 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S423,S425-SMAD3 [nucleoplasm]

p-S423,S425-SMAD3 [cytosol]

SMAD3 [cytosol]

p-T179,S423,S425-SMAD3 [nucleoplasm]

Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]

2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]

SMAD3 [nucleoplasm]

SMAD3 S425C [cytosol]

SMAD3 Y298* [cytosol]

SMAD3 R368* [cytosol]

SMAD3 E383* [cytosol]

SMAD3 S425F [cytosol]

SMAD3 Q322* [cytosol]

SMAD3 Q358* [cytosol]

SMAD3 E246* [cytosol]

SMAD3 W326* [cytosol]

SMAD3 Y384* [cytosol]

SMAD3 Q316* [cytosol]

p-S423,S425-SMAD3 R268H [cytosol]

p-S423,S425-SMAD3 R268C [cytosol]

p-S423,S425-SMAD3 D258N [cytosol]

Ub-SMAD3 [cytosol]

Inferred To

phospho-p-S208-SMAD3 [cytosol] (Gallus gallus)

phospho-p-S208-SMAD3 [cytosol] (Mus musculus)

phospho-p-S208-SMAD3 [cytosol] (Rattus norvegicus)

phospho-p-S208-SMAD3 [cytosol] (Sus scrofa)

phospho-Smox [cytosol] (Drosophila melanogaster)

phospho-Madh3 [cytosol] (Canis familiaris)

phospho-smad3a [cytosol] (Danio rerio)

phospho-daf-8 [cytosol] (Caenorhabditis elegans)

phospho-SMAD3 [cytosol] (Bos taurus)

Modified Residues

Name

O-phospho-L-serine at 208

Coordinate

208

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001138576.1, NP_001138574.1, NP_001138575.1, NP_005893.1

OpenTargets

ENSG00000166949

ENSEMBL

ENST00000558428, ENSP00000453082, ENST00000540846, ENST00000537194, ENSP00000452767, ENST00000559460, ENSP00000505445, ENST00000679624, ENST00000439724, ENSP00000437757, ENST00000681239, ENSP00000453684, ENSP00000505641, ENST00000327367, ENSP00000332973, ENST00000558739, ENSP00000401133, ENST00000558827, ENSP00000445348, ENSP00000454165

HPA

ENSG00000166949-SMAD3

PRO

P84022

Pharos - Targets

P84022

Orphanet

SMAD3

HMDB Protein

HMDBP14473

PDB

6ZMN, 5OD6, 5ODG, 6YIB, 5XOC, 2LAJ, 1U7F, 1MJS, 1OZJ, 2LB2, 1MK2, 1MHD

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.98	35
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.837	11
UniProt:O95405 ZFYVE9			0.821	7
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.805	9
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.805	9
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.799	8
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.779	7
UniProt:P50222 MEOX2			0.718	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.69	5
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.678	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.675	4
UniProt:Q9Y2U8 LEMD3	4	LEMD3 [endosome membrane] (R-HSA-9715091) LEMD3 [endoplasmic reticulum membrane] (R-HSA-9714458) LEMD3 [plasma membrane] (R-HSA-9715186) LEMD3 [nuclear envelope] (R-HSA-2993886)	0.669	4
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.667	5
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.666	4
UniProt:Q8N5R6 CCD33			0.666	4
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.656	3
UniProt:Q64729	3	Ub-TGFBR1 [plasma membrane] (R-MMU-8869461) TGFBR1 [plasma membrane] (R-MMU-170839) phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (R-MMU-170849)	0.576	6
UniProt:Q9BZ29 DOCK9	1	DOCK9 [cytosol] (R-HSA-1012981)	0.576	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.573	2
UniProt:P10070 GLI2	11	GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471) p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.558	4
UniProt:P46934-3 NEDD4			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:P29466-3 CASP1			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:P0C264 SBK3			0.556	3
UniProt:Q8IXK0-5 PHC2			0.556	3
UniProt:E9PSE9 E9PSE9			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:Q96PZ7 CSMD1			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:Q8N684 CPSF7	2	CPSF7 [cytosol] (R-HSA-9715140) CPSF7 [nucleoplasm] (R-HSA-72012)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P15822 ZEP1			0.553	2
UniProt:P06428 VE6			0.547	2
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.544	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.543	3
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.543	3
UniProt:Q9GZZ8 LACRT			0.527	2
UniProt:P51141 Dvl1	4	Dvl1 [cytosol] (R-MMU-4641157) Dvl1 [cytosol] (R-MMU-1504179) phospho-Dvl1 [cytosol] (R-MMU-201700) phospho-Dvl1 [cytosol] (R-MMU-3772396)	0.527	2
UniProt:P98082 DAB2	3	DAB2 [cytosol] (R-HSA-8862456) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [plasma membrane] (R-HSA-2980808)	0.524	3
UniProt:Q9NYA4 MTMR4	2	MTMR4 [cytosol] (R-HSA-1604658) MTMR4 [early endosome membrane] (R-HSA-2187404)	0.524	2
UniProt:Q99814 EPAS1 (HIF2A)	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.519	2
UniProt:Q9BYW2 SETD2	1	SETD2 [nucleoplasm] (R-HSA-1183220)	0.508	2
UniProt:Q9BZL4 PP12C			0.508	2
UniProt:Q9H2X0 CHRD			0.508	2
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.508	2
UniProt:Q9Y3Q8 T22D4			0.508	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.508	2
UniProt:Q5D1E8 ZC3H12A	1	ZC3H12A [nucleoplasm] (R-HSA-9774235)	0.508	2
UniProt:Q01543 FLI1	1	FLI1 [nucleoplasm] (R-HSA-9616216)	0.508	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.499	2
UniProt:Q05066 SRY	1	SRY [nucleoplasm] (R-HSA-5627706)	0.499	3
UniProt:P06930 VE6			0.488	2
UniProt:P36801 VE6			0.488	2
UniProt:P23142 FBLN1	1	FBLN1 [extracellular region] (R-HSA-2161389)	0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q9NZH6 IL37	6	IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [cytosol] (R-HSA-9008584) IL37 [cytosol] (R-HSA-9008596) IL37(1-?) [cytosol] (R-HSA-9008602) IL37(?-218) [nucleoplasm] (R-HSA-9008702)	0.463	2
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.463	6

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